Metastatic UBC is associated with a poor prognosis and limited treatment options. PD-L1 expression is prevalent in this disease and may protect cancer cells from immune-mediated destruction by binding to its receptors PD-1 and B7.1. MPDL3280A is a human anti-PD-L1 mAb with an engineered Fc-domain designed for optimized efficacy and safety. MPDL3280A was well tolerated in this pretreated UBC population. 50% of pts treated responded to treatment. Responses were rapid and on-going. Biomarker analysis revealed pharmacodynamic markers, as well as markers of potential mechanisms of resistance to therapy. ***Updated results to be delivered at ASCO.
Keywords: immune therapy; bladder cancer; PD-L1; anti-PD-L1; phase I clinical trials
Lifestyle changes improve biomarkers associated with breast cancer recurrence and mortality two studies
A pair of Yale Cancer Center interventional studies involving breast cancer survivors found that lifestyle changes in the form of healthy eating and regular exercise can decrease biomarkers related to breast cancer recurrence and mortality. Effect of weight loss intervention on inflammatory and metabolic markers in breast cancer survivors. The lifestyle, exercise, and nutrition (LEAN) study. (#1505)
Authors (all from Yale): Erikka Loftfield, MPH; Maura Harrigan, MS, RD, CSO; Fangyong Li, MPH, MS; Xiaopan Yao; Brenda Cartmel, PhD; Yang Zhou, MPH; Mary Playdon, MPH; Lingeng Lu, MD, PhD ; Tara Sanft, MD; Melinda Irwin, PhD, MPH
In this study, obese or overweight women were randomized into two groups those who received weight loss and exercise counseling and a
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