The HOPE study looked at the effect of exercise on body weight, body fat, and inflammatory biomarkers in 121 women with joint pain from taking aromatase inhibitors (AI) as adjuvant therapy. Participants were randomized into two groups those who participated in twice-weekly strength training and 2.5 hr/wk of moderate-intensive aerobic exercise and those who did no exercise (control group). After 12 months, the study found that the exercise group experienced an approximate 3% weight and body fat loss, and 6% decrease in CRP levels compared to increases in the control group.
Previous findings from the HOPE study showed exercise improved AI-associated joint pain, but results from this analysis of favorable decreases in body weight, fat and CRP found these markers did not mediate the beneficial effect of exercise on AI joint pain. Further HOPE analyses will be conducted to determine the mechanism(s) of how exercise improves AI joint pain.
Other authors on the LEAN study, all from Yale, were Erikka Loftfield, MPH; Maura Harrigan, MS, RD, CSO; Fangyong Li, MPH, MS; Xiaopan Yao; Brenda Cartmel, PhD; Yang Zhou, MPH; Mary Playdon, MPH; Lingeng Lu, MD, PhD ; Tara Sanft, MD Other authors on the HOPE study were Brenda Cartmel, PhD; Cary Gross, MD; Fangyong Li, MPH, MS; Xiaopan Yao; Martha Fiellin, MPH; Elizabeth Ercolano, PhD; Maura Harrigan, MS, RD, CSO; Yang Zhou, MPH; Tara Sanft, MD; Kathryn Schmitz, PhD; Dawn Hershman, MD; Jennifer Ligibel, MD Yale University, New Haven, CT; University of Pennsylvania, Philadelphia, PA; Columbia University, New York, New York; Dana Farber Cancer Institute, Boston, MA.
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