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The first US trial for AeroLEF(TM) has been cleared to proceed by the FDA and is pending clearance with the relevant Investigator Review Boards."


Nimotuzumab, a humanized monoclonal antibody that targets the epidermal growth factor receptor (EGFR), is currently in varying stages of development in a number of trials, including colorectal cancer, adult and pediatric glioma, non-small-cell lung cancer and pancreatic cancer. During the first quarter of fiscal 2008:

- YM initiated enrollment for a Phase II colorectal cancer trial in

Canada. As of today, 30 patients have been enrolled in the first 50-

patient cohort, with recruitment of this cohort expected to be

completed by the end of calendar 2007 and data from this cohort are

expected to be reported in early calendar 2008. The endpoints of the

trial include Objective Response Rate (ORR), Progression Free

Survival (PFS), Overall Survival (OS) and the rates and durations of

Stable Disease (SD), as well as safety.

- YM USA was cleared by the US FDA to expand its second-line clinical

trial in children with DIPG into the US.

- YM reported positive preliminary results of a Phase I/II trial of

nimotuzumab in combination with radiation for the treatment of non-

small-cell lung cancer (NSCLC).

- Oncoscience AG reported completion of patient enrollment in the

Phase III, first-line, pediatric DIPG trial.

- Oncoscience AG reported initiation of late-stage trials designed to

be supportive of registration in adult glioma and pancreatic cancer.

- Subsequent to the end of the quarter:

- YM received clearance from Health Canada to extend into Canada the

188-patient multi-centre randomized, placebo controlled

Phase IIb/IIIa study in chemotherapy-naive patients with locally

advanced or metastatic pancreatic ca

SOURCE YM BioSciences Inc.
Copyright©2007 PR Newswire.
All rights reserved

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