Navigation Links
Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults
Date:1/22/2014

A second systematic review of a diagnostic test for tuberculosis (TB) endorsed by the World Health Organisation (WHO), has confirmed the accuracy of the test. The updated review assessing the accuracy of Xpert MTB/RIF includes new studies published since the original Cochrane Review was published in January last year. Led by Karen Steingart, an Editor with the Cochrane Infectious Diseases Group at LSTM, the researchers found that Xpert MTB/RIF is more accurate than smear microscopy for diagnosing TB and also accurate for detecting rifampicin resistance. This updated Cochrane Review was one of three WHO reviews commissioned as part of the process to update the policy on the use of Xpert MTB/RIF. The WHO policy is available at http://www.stoptb.org/wg/gli/xpert.asp.

TB causes tremendous suffering worldwide, especially in low- and middle-income countries. Around 8.6 million people developed the disease for the first time in 2012 and 1.3 million people died. TB can be cured if the disease is diagnosed and properly treated. Being able to detect TB and TB drug resistance is vital for improving health, reducing deaths and decreasing the spread of TB.

Xpert MTB/RIF is a new test that quickly detects TB and resistance to rifampicin, one of the major drugs for treating the disease. Xpert MTB/RIF is automated and can detect TB bacteria at low concentrations. In addition, the test does not require expert staff or an advanced laboratory. In contrast, smear microscopy, the most frequently used test for TB detection in resource-constrained settings requires TB bacteria to be present at high concentrations (thousands of bacteria) and does not diagnose drug resistance. Instead TB would have to be grown in a laboratory, which requires time and expert staff.

This updated review, involving around 9500 people, analysed data from an additional nine studies alongside the 18 included originally. Most of the studies were performed in low- or middle-income countries. The findings in the updated review are consistent with those reported previously.

The review found that for TB detection, Xpert MTB/RIF was accurate (it was sensitive (89%), detecting almost all cases; and specific (99%) that is, not registering positive in people who were actually negative).

For rifampicin resistance detection, Xpert MTB/RIF was accurate with sensitivity at 95% and specificity at 98%.

Xpert MTB/RIF appeared to have similar accuracy in people with and without HIV infection.

Applying the findings of the review to an imaginary group of 1000 people who go to their doctor with symptoms, but where only 100 of them (10%) actually have TB, Xpert MTB/RIF would diagnose 88 cases and miss 12, whereas smear microscopy would diagnose 65 cases and miss 35 cases.

Managing Editor of the Cochrane Infectious Diseases Group, Anne-Marie Stephani said: "Given the large number of studies that have assessed the accuracy of Xpert MTB/RIF, the WHO Global TB Programme commissioned a review to summarize the evidence. This updated review, like the original, shows that Xpert MTB/RIF is accurate for diagnosing TB and detecting rifampicin resistance, an indicator of multidrug-resistant TB. Xpert MTB/RIF may be useful in many countries, particularly in low- and middle-income countries where TB is prevalent, as it does not require advanced laboratory facilities or expert staff." She added, "The tests are expensive, so current research evaluating the use of Xpert MTB/RIF in TB programmes in high TB burden settings will help evaluate how this investment may help start treatment promptly and improve patient health."


'/>"/>
Contact: Clare Bebb
c.bebb@liv.ac.uk
44-015-170-53135
Liverpool School of Tropical Medicine
Source:Eurekalert

Related medicine news :

1. Cutting-edge approaches to ensuring biologic drug quality focus of forum on bioassays
2. Research: Chemoresponse assay helps boost ovarian cancer survival
3. Global Immunoassay Systems Market 2012 - 2016 Available by MarketResearchReports.Biz
4. Genomic assay as an alternative to animal testing
5. ChanTest Announces ChansPorter™ Assays to Accelerate Drug Development for Cystic Fibrosis Patients
6. Harvard Medical School is Presenting “Neutrophil Chemotaxis Assay from One Drop of Blood” at Sample Prep East in Cambridge, MA, December 9-10, 2013
7. 17 Billion-Dollar Immunoassay Market Far From Mature, Says Kalorama Report
8. ATCC Examined the Importance of High-quality Controls in Assay Design and Development During the Association for Molecular Pathology (AMP) 2013 Annual Meeting
9. Vitamin C improves pulmonary function in newborns of pregnant smoking women
10. Pittsburgh Cardiologist Named Physician of the Year by Pulmonary Hypertension Association
11. A hands-on approach to treating patients with pulmonary disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... "FCPX editors can now reveal their media with growing ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings ... users can now reveal the media of their split screens with growing colorful panels. ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Revolutionary technology includes multi-speaker listening to ... leaders in advanced audiology and hearing aid technology, has ... the world,s first internet connected hearing aid that opens ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... firsts,: , TwinLink™ - the first dual ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
(Date:6/23/2016)... 2016  Experian Health, the healthcare industry ... patient payment and care experience, today announced ... and services that will enhance the breadth ... These award-winning solutions will enable healthcare professionals ... in an ever-changing environment and redefine front-office ...
Breaking Medicine Technology: