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XENAZINE(R) (Tetrabenazine) Approved by FDA for Patients with Chorea Associated with Huntington's Disease
Date:8/15/2008

re than 30 years.

About Huntington's Disease

Affecting an estimated 30,000 Americans, HD is a devastating neurodegenerative disease that causes progressive movement disorders, cognitive dysfunction and behavioral changes and is ultimately a fatal condition. Chorea is the most common symptom, affecting approximately 90% of HD patients, and is characterized by excessive, involuntary and repetitive movements, which are the most visible and dangerous manifestations of HD and interfere with patients' abilities to perform activities of daily living, including dressing, bathing and caring for themselves. For more information about HD, please visit http://www.hdfoundation.org or http://www.hdsa.org.

About XENAZINE (tetrabenazine)

XENAZINE is indicated for the treatment of chorea associated with Huntington's disease. A selective and reversible centrally-acting dopamine depleting drug, XENAZINE works by inhibiting a molecule known as VMAT2 (vesicular monoamine transporter 2). XENAZINE has been designated as an "orphan drug" by the FDA and will have seven years market exclusivity in the United States. Full prescribing information will be available at http://www.prestwickpharma.com in the near future.

Important Safety Information

The most frequent and serious adverse events seen with tetrabenazine are somnolence/sedation and insomnia, respectively. Adverse events reported with XENAZINE included depression, akathisia, parkinsonism and sedation. XENAZINE's effects are largely reversible and manageable.

About Prestwick

Prestwick Pharmaceuticals, a privately-held pharmaceutical company headquartered in Washington, DC, is currently managing product candidates for CNS conditions with significant unmet needs, including Huntington's disease, schizophrenia, and sleep apne
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SOURCE Prestwick Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
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