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Wyeth Comments on PREVNAR and Trends in Pneumococcal Disease
Date:10/4/2007

stant bacteria, not vaccine use."

Since the introduction of PREVNAR in the United States in 2000, the rate of antibiotic-resistant IPD decreased through 2004 by 98 percent (95% CI: 97.6-98.4) for vaccine serotypes and 81 percent (95% CI: 80-82) for all serotypes in children younger than two years of age.

Wyeth has a 13-valent pneumococcal conjugate vaccine in late-stage development that includes serotype 19A, as well as serotypes 1, 3, 5, 6A and 7F, in addition to the seven serotypes (4, 6B, 9V, 14, 18C, 19F and 23F) included in PREVNAR. The investigational 13-valent vaccine currently is in global Phase 3 clinical trials and may offer broader coverage than the 7- valent vaccine.

In view of the demonstrated vaccine efficacy and high disease burden in young children, the World Health Organization (WHO) recently recommended priority inclusion of the pneumococcal conjugate vaccine in national immunization programs worldwide. The Advisory Committee on Immunization Practices for the Centers for Disease Control and Prevention recommends pneumococcal conjugate vaccine for all infants as do many other countries. PREVNAR, the only licensed pneumococcal conjugate vaccine, now is available in more than 80 countries worldwide and is part of the routine national childhood immunization schedule in 17 of these countries.

Pneumococcal Disease

Pneumococcal disease affects both children and adults and is a leading cause of illness and death worldwide. Pneumococcal disease is caused by the bacterium Streptococcus pneumoniae and describes a group of illnesses, including invasive infections, such as bacteremia/sepsis and meningitis, as well as pneumonia and upper respiratory tract infections, including otitis media and sinusitis. WHO estimates that pneumococcal disease results in up to one million deaths each year in young children worldwide. Further, according to WHO, pneumococcal disease is the number one vaccine-preventable cause of death in children less
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