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Wyeth Comments on PREVNAR and Trends in Pneumococcal Disease
Date:10/4/2007

- Data Presented This Week at Major Medical Meeting Reinforce Need for

Broader Spectrum Pneumococcal Vaccines -

COLLEGEVILLE, Pa., Oct. 4 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), comments on studies to be presented this week at the 45th Annual Meeting of the Infectious Diseases Society of America (IDSA) concerning PREVNAR(R) (Pneumococcal 7-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), a vaccine which helps to protect against the seven pneumococcal serotypes causing the majority of disease worldwide. Key studies report the broad public health impact of routine use of PREVNAR in the United States, including a 98 percent reduction in vaccine-type invasive pneumococcal disease (IPD) among children younger than five years of age compared with a pre-vaccine baseline; the data also detail the emergence of disease caused by non-vaccine serotype 19A, underscoring the need for broader spectrum pneumococcal vaccines.

"It is important to note that some non-vaccine serotypes, most notably 19A, are emerging globally and have been documented both in regions where PREVNAR is available, as well as in areas where it is not widely used," says Peter Paradiso, Ph.D., Vice President, Scientific Affairs, Wyeth Vaccines. "For example, data to be presented at IDSA from Korea show an increase in disease caused by serotype 19A prior to the introduction of PREVNAR; this indicates that such events may occur in the absence and independent of vaccination. While data suggest that some antibiotic-resistant strains of nonvaccine serotype 19A are emerging, it should be noted that the overuse of antibiotics has long been established as the primary cause of antibiotic- resi
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SOURCE Wyeth Pharmaceuticals
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