Navigation Links
Wyeth Announces Positive Data from Phase 2 Study of Neratinib in Advanced HER-2-Positive Breast Cancer
Date:12/12/2008

- Global Phase 3 Program Expected to Begin in December -

COLLEGEVILLE, Pa., Dec. 12/PRNewswire-FirstCall/ --Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), today announced data from an open-label phase 2 clinical trial of neratinib (HKI-272) in women with advanced HER-2-positive breast cancer. These data suggest that neratinib has antitumor activity in patients with advanced breast cancer positive for the ErbB-2 receptor (also known as HER-2 or Neu). These data were presented today during an oral session at the CTRC-AACR San Antonio Breast Cancer Symposium.

Neratinib is an investigational orally-administered potent and irreversible dual inhibitor of the HER-2 and EGFR kinases. Wyeth expects to initiate the first study in a global phase 3 program for neratinib in advanced HER-2-positive breast cancer later this month.

"Neratinib demonstrated activity against trastuzumab-resistant and trastuzumab-naive HER-2-positive breast cancer," said Harold Burstein, M.D., Ph.D., a study lead investigator at Dana-Farber Cancer Institute in Boston. "These results warrant ongoing study to see whether neratinib will fit into our armamentarium of anti-HER2 drugs."

The phase 2 study evaluated the safety and efficacy of a daily 240 mg oral dose of neratinib in 136 women diagnosed with ErbB-2-positive locally advanced or metastatic breast cancer (stage IIIB, IIIC or IV). The primary end point of the open-label, two-arm study was the 16-week progression-free survival (PFS) rate. Secondary end points included safety, objective response rate (complete and partial responses) and clinical benefit rate (objective response plus stable disease).

Patients were assigned to one of two study arms based on prior treatment with trastuzumab (Herceptin(R), Gene
'/>"/>

SOURCE Wyeth Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Wyeth Sets Webcast and Conference Call for 2008 Fourth Quarter and Full Year Earnings
2. Wyeth to Present at the Credit Suisse Healthcare Conference
3. The Senior Citizens Leagues Comments on U.S. Supreme Court Case Wyeth v. Levine
4. Wyeth v. Levine: Preemption and The Facts
5. Advanced Life Sciences and Wyeth Sign Commercialization Agreement for Cethromycin in Asia Pacific Region
6. Wyeth Selected for 11th Consecutive Year as One of Working Mother Magazines 100 Best Companies for Working Mothers
7. Wyeth Consumer Healthcare Signs Agreement to Purchase ThermaCare from Procter & Gamble
8. Wyeth to Present at the Goldman Sachs Annual Global Healthcare Conference
9. Wyeths Pristiq, a New Treatment for Major Depressive Disorder in Adults, Now Available in U.S. Pharmacies
10. Wyeth to Present at the Morgan Stanley Global Healthcare Unplugged Conference
11. Wyeth Holds Annual Meeting of Stockholders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... The microscopy market is estimated to ... $5,756.0 million by 2019. Optical microscopy is the ... microscopes product segment is expected to show the ... focus on nanotechnology, technological advancements, and increasing federal ... , Get Full Copy of Report @ ...
(Date:12/25/2014)... TX (PRWEB) December 26, 2014 The ... to 2023” focuses on the current treatment landscape, unmet ... cancer market. TS-1 is an anti-cancer drug which is ... orally and is also used for treating gastric cancer ... and otastat potassium. The drug was first approved in ...
(Date:12/25/2014)... 26, 2014 Recently, Dylan Queen, a ... excitedly released its collection of discounted prom dresses, most ... a senior spokesman of the company, the promotion is ... promotion is to expand the UK market. , The ... different colors, lengths, and styles: A-line strapless, empire strapless ...
(Date:12/25/2014)... 25, 2014 Helen Harris’ RP (Retinitis ... Hills, California after an 8 year battle with breast ... Eve evening in her home in Woodland Hills California ... cancer. , As the founder and ... she pioneered and championed many of today's greatest breakthroughs ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- The risk of ... holidays, so you need to be extra cautious, an ... we see a significant increase in patients coming in ... the Suffolk County Volunteer Firefighters Burn Center of Stony ... should be full of joy, but if not careful, ...
Breaking Medicine News(10 mins):Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Don't Let Burns Mar Your Holidays 2
... Group, Inc.,(NYSE Alternext US: QGP) ( www.QuantumMD.com ) announced ... debut at the 2009 Pri-Med,South Conference and Expo alongside ... Quantum believes PWeR is the next generation in healthcare ... Obama is calling for within,the industry. Pete Martinez, ...
... . , This minimally invasive procedure, pioneering ... surgeons at the University Hospital of Navarra, which brings ... , The results obtained in patients were recently published ... Annals of Surgery . It is the highest ...
... research plays a significant role in African-Americans, lack ... study by researchers at Children,s Hospital of Pittsburgh ... School of Public Health. , African-Americans are ... published in the February issue of Archives ...
... Iowa, Feb. 3 Bio-Research Products,announced today that it ... enzyme Glutathione Reductase (GR). Dr. Bryce Cunningham, President and,Chief ... first,commercial version of the enzyme as a readily soluble ... Glutathione Reductase is part of test kits ...
... New hidden-camera footage from Tucson, AZ, implicates a ... scandal. In the video, UCLA student Lila ... Planned Parenthood clinic where Rose tells the nurse that ... 27-year-old boyfriend. The nurse disregards the age difference and ...
... The Center for Association Resources, an,association management and ... is pleased to announce the launch of an,innovative e-learning ... in the,healthcare industry. The implementation of the service will ... as deliver educational segments via,CCTV. , ...
Cached Medicine News:Health News:PWeR(TM) Introduced at Regional Healthcare Conference 2Health News:PWeR(TM) Introduced at Regional Healthcare Conference 3Health News:PWeR(TM) Introduced at Regional Healthcare Conference 4Health News:Surgical technique in Spain enables extirpation of benign tumors of the pancreas 2Health News:Children's Hospital study finds African-Americans more distrusting of research than whites 2Health News:Children's Hospital study finds African-Americans more distrusting of research than whites 3Health News:New Undercover Video Shows Tucson Planned Parenthood Hiding Rape of 15-Year-Old Girl 2Health News:Center for Association Resources Launches E-Learning Service 2
(Date:12/24/2014)... , December 24, 2014 ... on Global Disposable Syringe Industry of 178 ... online business intelligence library. The ... Syringe Industry is a professional and deep ...  For overview analysis, the report introduces Disposable ...
(Date:12/24/2014)... CHENGDU, China , Dec. 23, 2014 /PRNewswire/ ... a pharmaceutical company that specializes in patented biopharmaceutical, ... active pharmaceutical ingredients (API) today announced that the ... for its Good Manufacturing Practice (GMP) certificate of ... & Drug Administration,s (CFDA). The public notice period ...
(Date:12/22/2014)... 22, 2014 NxStage Medical, Inc. (NASDAQ: ... dialysis products, announced today that the U.S. Food ... One™ to perform hemodialysis overnight while the patient ... hemodialysis. NxStage,s® System One is the first and ... this indication. Home nocturnal hemodialysis ...
Breaking Medicine Technology:World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3
... WASHINGTON, March 7, 2011 RainDance Technologies, Inc. ... focused on the development and commercialization of a ... genetic screening panel for use on next-generation sequencing ... with the Society of Toxicology,s 50th Annual Meeting ...
... March 7, 2011 Dyadic International, Inc. (OTC Pink: ... will release financial results for the year ended December ... open to be followed by a conference call at ... The conference call may be accessed by dialing ...
Cached Medicine Technology:RainDance Technologies and Ambry Genetics Expand Collaboration to Address ADME Analysis 2RainDance Technologies and Ambry Genetics Expand Collaboration to Address ADME Analysis 3RainDance Technologies and Ambry Genetics Expand Collaboration to Address ADME Analysis 4
... The table top design takes into account ... creates a flexible working environment for the ... alphamaxx can be matched exactly to your ... slide capability creates superior access for image ...
... is the Market leader in soft tissue ... DePuy Mitek has developed the latest evolution ... shoulder repair. ORTHOCORD Suture is as strong ... market. Most importantly, ORTHOCORD Suture handles like ...
... Now you can ... tactile sensitivity of the ... Free surgical gloves on ... Free gloves provide the ...
... Siegel MAST Intraoperative Leg Positioner frees the OR ... need for 2nd assistants to hold the leg, ... the procedure instead of leg positioning. The Siegel ... the leg in any position required for knee ...
Medicine Products: