Navigation Links
Wound-healing role for microRNAs in colon offer new insight to inflammatory bowel diseases
Date:5/23/2014

of mammals. Dr. Mendell's laboratory studies how these tiny regulators work normally and how diseases such as cancer arise when they function in an abnormal manner.

These latest findings, which appear in the journal Cell, focus on two microRNAs: miR-143 and miR-145. While there is extensive literature implicating these microRNAs in colon cancer, little is known about their natural function in the colon. So Dr. Guanglu Shi, postdoctoral researcher in Molecular Biology, and other researchers began their five-year investigation by removing or "knocking out" the gene that produces these two microRNAs in mouse models.

The researchers found that the cells that normally increase their growth to make repairs, called epithelial cells, fail under stress in the knockout animals. Epithelial cells line the intestines where food is digested, separating the contents from the rest of the body and absorbing needed nutrients.

"The epithelial cells of the colon normally proliferate quickly to fill in the wounds from an injury. Without these microRNAs, the epithelial cells are unable to switch into this repair mode, so they never heal the wounds and the mice are not able to survive," Dr. Shi said.

In addition, the research upended traditional thinking about where the tiny microRNAs reside, discovering to everyone's surprise that they reside in supporting cells, called mesenchymal cells, instead of the epithelial cells themselves as previously thought.

"This was surprising because colon cancers derive from the epithelial cells, so it was assumed that the microRNAs must function within them," Dr. Mendell said. "If these microRNAs do participate in colon cancer, they must do so by acting from outside the epithelium."

Identifying the accurate location of t
'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
2. Wayne State to study role of microRNAs in prostate cancer racial disparities
3. Versatile microRNAs choke off cancer blood supply, suppress metastasis
4. Atherosclerosis: Specific microRNAs promote inflammation
5. MicroRNAs can convert normal cells into cancer promoters
6. Pint-size microRNAs show promise against weighty problem, researchers say
7. Study shows how streptococcal bacteria can be used to fight colon cancer
8. Immune cells found to fuel colon cancer stem cells
9. Dual method to remove precancerous colon polyps may substantially reduce health-care costs
10. Scientists find key steps linking dietary fats and colon cancer tumor growth
11. Surveillance colonoscopy recommendations for average-risk patients with 1 to 2 small polyps consistent with guidelines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Wound-healing role for microRNAs in colon offer new insight to inflammatory bowel diseases
(Date:10/30/2014)... Tanaka and her research group at the DFG Research ... at the TU Dresden (CRTD) demonstrated for the first ... spinal cord in three dimensions from mouse embryonic stem ... dorsal interneurons along the dorsal/ventral axis was observed., This ... " Stem Cell Reports " on 30.10.2014 ., ...
(Date:10/30/2014)... Nutrition Leaders, a popular online retailer ... and more, is currently hosting a sweepstakes on its ... is open to U.S. residents age 18 and over, ... One lucky winner will then be selected at random ... card to NutritionLeaders.com. , Nutrition Leaders’ managing director Kimba ...
(Date:10/30/2014)... 2014 Graphics, coding, typography and search ... the craft of web design and require thorough knowledge ... simpler solution to create a website can be as ... information, customer reviews and Facebook posts all accumulate on ... the next evolution of how a business can develop ...
(Date:10/30/2014)... Calif. (PRWEB) October 30, 2014 ... mutually exclusive concepts in the medical-grade skin care ... the development of uniquely potent topical dermatological products, ... System ( http://www.RefinitySkinScience.com ) with patented COSMEDERM®-7 anti-irritant ... glycolic acid concentrations (50% and 70%) and a ...
(Date:10/30/2014)... PreDiabetes Centers , the pioneer ... shoppers with a supply of sugardown®, a chewable dietary ... blood sugar spikes. Learning how to control blood sugar ... of a diabetes prevention plan. , Shoppers who spend ... tube of sugardown. The offer expires November 30. ...
Breaking Medicine News(10 mins):Health News:Reconstruction of a patterned piece of spinal cord in 3-D culture 2Health News:Nutrition Leaders Announces Gift Card Sweepstakes 2Health News:Facebook Websites In Thirty-Seconds 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 3Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 4Health News:PreDiabetes Treatment Company Offers PreD Store Shoppers Supplements to Support Healthy Blood Sugar 2
... , , , NEW YORK, June 10 Vendome ... magazines and producers of the HEALTHCARE DESIGN.09 Conference announces the 2009 ... those who are unable to afford the cost of the conference ... fee. , , "We believe, as a company ...
... condition in which patients, aortic valves have just two leaflets instead ... up to two percent of the general population. The defect ... the valve and may results in a feeling of tightness in ... is easily diagnosed; often physicians can hear a "click" or a ...
... vomiting disease invades cells by attaching to particular sugar ... the conclusion of a thesis presented at the Sahlgrenska ... an important step in the development of a drug ... Winter vomiting disease is an infectious inflammation ...
... Illinois, USA June 10, 2009 The most important ... are the types of diagnostic tests performed and whether or ... they can ensure that only patients who need readily accessible ... study published today in the Journal of Hospital Medicine ...
... search platform to enable healthcare professionals to find Medicare ... 10 Vivisimo ( www.vivisimo.com ), a ... provider of education and information on healthcare regulatory compliance ... platform to power search on ...
... Organizations team pilot chronic care management tools in a ... Microsoft Corp., in collaboration with the University ... Family Medicine and Community Health, the city of Miami, ... in Miami,s Overtown neighborhood aimed at changing the way ...
Cached Medicine News:Health News:HEALTHCARE DESIGN.09 Announces Scholarship Program 2Health News:First-degree relatives of patients with bicuspid aortic valve should be screened 2Health News:Drugs against winter vomiting disease one step closer 2Health News:Availability of diagnostic tests drive success in hospitalist-run short-stay units 2Health News:HCPro Selects Vivisimo Velocity to Launch MedicareFind.com 2Health News:HCPro Selects Vivisimo Velocity to Launch MedicareFind.com 3Health News:The University of Miami Miller School of Medicine, the City of Miami, Microsoft and Resolute Solutions Seek to Improve Care of Diabetic Populations Using Collaborative Technology 2Health News:The University of Miami Miller School of Medicine, the City of Miami, Microsoft and Resolute Solutions Seek to Improve Care of Diabetic Populations Using Collaborative Technology 3
(Date:10/30/2014)... FARMINGDALE, N.Y. , Oct. 30, 2014  Misonix, ... surgical device company that designs, manufactures and markets innovative ... surgical specialties, announced today that it will report financial ... Thursday, November 6, 2014. The Company has scheduled a ... at 4:30 pm ET to review the results. ...
(Date:10/30/2014)... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... company serving the pharmaceutical, biotechnology, and medical device industries, ... the United States , today announced ... Tel Aviv area of Israel.  ... platform of integrated R&D services to local customers. It ...
(Date:10/30/2014)... Oct. 30, 2014  Electronic health records uptake ... result of government initiatives and the considerable resources ... have invested over the past five years. Electronic ... IT, and U.S. clinicians use them on a ... http://photos.prnewswire.com/prnh/20141029/155278LOGO Frost & Sullivan,s ...
Breaking Medicine Technology:Misonix, Inc. To Report First Quarter Fiscal Year 2015 Financial Results On Thursday, November 6, 2014 2WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Electronic Health Record Usability: CIOs Weigh In 2Electronic Health Record Usability: CIOs Weigh In 3Electronic Health Record Usability: CIOs Weigh In 4
... Inc.,("CeloNova"), leading and accelerating healthcare solutions through ... breakthrough,results from the ATLANTA study of the ... the 20th Annual International Symposium on,Endovascular Therapy ... Corrado Tamburino, MD, President of the ...
... Ortho Women,s Health,& Urology(TM), Division of ... for ORTHO EVRA(R),(norelgestromin/ethinyl estradiol transdermal system) to ... includes two new additional estimates of relative,risk ... of 1.1,(indicating no increase in risk) and ...
Cached Medicine Technology:CeloNova BioSciences Introduces a New Class of Coronary Stent: The CATANIA(TM) Coronary Stent System with NanoThin Polyzene(R)-F 2ORTHO EVRA(R) Prescribing Information Updated 2ORTHO EVRA(R) Prescribing Information Updated 3
... IOL is a foldable silicone IOL. It ... and is designed to be inserted with ... Multifocal IOL is the first and only ... offer patients a full range of functional ...
1% Sodium Hyaluronate, 10mg/mL, sterile opthalmic injection...
... Ocucoat is a 2% Hydroxypropyl Methylcellulose solution ... surgeons performing high volume, small incision surgery. ... allows for rapid removal with minimal risk ... Ocucoat permits an unobstructed view of the ...
... Amvisc is the right viscoelastic agent for ... the planned extracap technique. Amvisc possesses sufficient ... removal. Amvisc is highly cohesive so that ... case is easily and quickly accomplished. Amvisc ...
Medicine Products: