Navigation Links
Worms Reveal More of Longevity's Secrets
Date:4/16/2009

The way cells use oxygen could keep them younger, longer

THURSDAY, April 16 (HealthDay News) -- Worms are providing scientists with new insights into how cells and tissues may stay youthful over the long term.

A protective mechanism used by cells to stay alive when oxygen levels are low (called a hypoxic response) promotes longevity and helps defend against some age-related diseases, a new study finds.

"This is a completely new pathway for aging and age-associated disease," senior author Dr. Matt Kaeberlein, an assistant professor of pathology at the University of Washington, Seattle, said in a university news release.

His team found that nematode worms live longer if they're also able to switch on the hypoxic response when oxygen levels are normal. In addition, the worms' cells contain fewer toxic proteins that might accumulate and clump together as they age.

The study is in the April 16 issue of the journal Science.

Buildups of toxic protein occur in the brain cells of people with Alzheimer's disease, Huntington's disease and a number of other degenerative conditions seen in the elderly, the researchers noted. Learning more about the cellular mechanisms that prevent accumulation of toxic proteins could help researchers find new treatments for these age-related diseases.

"The (study) findings suggest that hypoxic response promotes longevity and reduces the accumulation of toxic proteins by a mechanism that is distinct from both dietary restriction and insulin-like signaling. It appears to be an alternative pathway," Kaeberlein said.

"However, we don't know if future studies might reveal that all of these different genetic pathways converge somewhere down the line into a common mechanism for delaying the effects of age," he added.

The key factor that controls hypoxic response is called HIF, and the UW researchers are now trying to determine how HIF protects the worms from aging. In both worms and humans, HIF regulates the activity of several factors that play a role in aging and resistance to stress.

"If we can understand at a very detailed level how HIF is slowing aging, we may be able to use that information to develop effective therapies for treating age-associated diseases in people," Kaeberlein said.

More information

The U.S. Centers for Disease Control and Prevention offers tips for healthy aging.



-- Robert Preidt



SOURCE: University of Washington, news release, April 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hookworms in MS trial
2. Ben-Gurion University of the Negev initiates project to eliminate intestinal worms in Ethiopia
3. Warmer Weather Reminds Cat Owners to Protect Against Worms
4. UC San Diego researchers target tumors with tiny nanoworms
5. Iron banded worms drying out of blood could be linked to Parkinsons and Alzheimers
6. CDC Reports Prevalence of Worms Transmitted by Dogs and Cats to Humans is Higher Than Previously Understood
7. Study Reveals How Salmonella Hijacks Cells
8. Generic Pharmaceuticals Offer Exciting Growth Opportunities in Tanzania, Reveals Frost & Sullivan
9. UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases
10. Brain Scans Reveal Secrets of Writers Cramp
11. National Survey Reveals Gap in Uncontrolled Asthma Knowledge - Putting Asthma Patients at Risk for Serious Health Consequences
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Worms Reveal More of Longevity's Secrets
(Date:2/6/2016)... ... February 06, 2016 , ... ... EXPECTED AT AORN SURGICAL CONFERENCE & EXPO , WHAT:     , This conference ... estimated 5000 perioperative nurses in attendance to study the latest evidence-based recommendations ...
(Date:2/6/2016)... ... ... Shark Finds and Kevin Harrington, along with the Product Managers ... Belly Bands. , Having a dog is great—except when it wets every couch, bed, ... works, get Belly Bands, the easiest way to stop dogs from wetting on ...
(Date:2/5/2016)... NY (PRWEB) , ... February 05, 2016 , ... Love ... long-stem roses in a variety of colors, assortments and packaging. This staple for Valentine’s ... any King Kullen location. , For Valentine’s Day, not only are long-stem roses ...
(Date:2/5/2016)... ... February 05, 2016 , ... Successful recruitment ... new clinical and scientific initiatives have all marked the last 12 months at ... and CEO of the nation’s oldest cancer center, Candace S. Johnson, PhD, outlined ...
(Date:2/5/2016)... ... February 05, 2016 , ... Francisco Canales, MD and ... their Napa Valley office. The technique utilizes the body’s own healing abilities to ... Dr. Furnas, are part of only a select few cosmetic surgeons bringing this ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... filed in the United States District Court for the District ... class (the "Class") consisting of all persons or entities who ... "Company") (NASDAQ: INSY ) from March 3, 2015 through ... and certain of its officers with violations of the Securities ...
(Date:2/4/2016)... Feb. 4, 2016 Summary Breast cancer, ... and the most common cancer in women worldwide, accounting ... exceedingly prevalent. The number of women diagnosed with breast ... the number of deaths has declined due to earlier ... has been revolutionized in the past four decades, especially ...
(Date:2/4/2016)... Feb. 4, 2016 Mettler-Toledo International Inc. (NYSE: ... 2015.  Provided below are the highlights: , ... compared with the prior year.  Reported sales decreased 3% ... quarter. , Net earnings per diluted share as ... prior- year period.  Adjusted EPS was $4.65, an increase ...
Breaking Medicine Technology: