Navigation Links
Worms Reveal More of Longevity's Secrets
Date:4/16/2009

The way cells use oxygen could keep them younger, longer

THURSDAY, April 16 (HealthDay News) -- Worms are providing scientists with new insights into how cells and tissues may stay youthful over the long term.

A protective mechanism used by cells to stay alive when oxygen levels are low (called a hypoxic response) promotes longevity and helps defend against some age-related diseases, a new study finds.

"This is a completely new pathway for aging and age-associated disease," senior author Dr. Matt Kaeberlein, an assistant professor of pathology at the University of Washington, Seattle, said in a university news release.

His team found that nematode worms live longer if they're also able to switch on the hypoxic response when oxygen levels are normal. In addition, the worms' cells contain fewer toxic proteins that might accumulate and clump together as they age.

The study is in the April 16 issue of the journal Science.

Buildups of toxic protein occur in the brain cells of people with Alzheimer's disease, Huntington's disease and a number of other degenerative conditions seen in the elderly, the researchers noted. Learning more about the cellular mechanisms that prevent accumulation of toxic proteins could help researchers find new treatments for these age-related diseases.

"The (study) findings suggest that hypoxic response promotes longevity and reduces the accumulation of toxic proteins by a mechanism that is distinct from both dietary restriction and insulin-like signaling. It appears to be an alternative pathway," Kaeberlein said.

"However, we don't know if future studies might reveal that all of these different genetic pathways converge somewhere down the line into a common mechanism for delaying the effects of age," he added.

The key factor that controls hypoxic response is called HIF, and the UW researchers are now trying to determine how HIF protects the worms from aging. In both worms and humans, HIF regulates the activity of several factors that play a role in aging and resistance to stress.

"If we can understand at a very detailed level how HIF is slowing aging, we may be able to use that information to develop effective therapies for treating age-associated diseases in people," Kaeberlein said.

More information

The U.S. Centers for Disease Control and Prevention offers tips for healthy aging.



-- Robert Preidt



SOURCE: University of Washington, news release, April 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hookworms in MS trial
2. Ben-Gurion University of the Negev initiates project to eliminate intestinal worms in Ethiopia
3. Warmer Weather Reminds Cat Owners to Protect Against Worms
4. UC San Diego researchers target tumors with tiny nanoworms
5. Iron banded worms drying out of blood could be linked to Parkinsons and Alzheimers
6. CDC Reports Prevalence of Worms Transmitted by Dogs and Cats to Humans is Higher Than Previously Understood
7. Study Reveals How Salmonella Hijacks Cells
8. Generic Pharmaceuticals Offer Exciting Growth Opportunities in Tanzania, Reveals Frost & Sullivan
9. UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases
10. Brain Scans Reveal Secrets of Writers Cramp
11. National Survey Reveals Gap in Uncontrolled Asthma Knowledge - Putting Asthma Patients at Risk for Serious Health Consequences
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Worms Reveal More of Longevity's Secrets
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening to conquer ... in advanced audiology and hearing aid technology, has today ... world,s first internet connected hearing aid that opens up ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... , TwinLink™ - the first dual communication ...
(Date:6/23/2016)... Research and Markets has announced ... Analysis (United States, China, Japan, Brazil, United Kingdom, Germany, ... offering. Surgical Procedure ... planners, provides surgical procedure volume data in a geographic ... in-depth analysis of growth drivers and inhibitors, including world ...
(Date:6/23/2016)...  The National Pharmaceutical Council (NPC) today announced ... research organization as its newest member.  ... president and chief scientific officer, Mallinckrodt Pharmaceuticals, will ... Board of Directors. ... us in support of our efforts to conduct ...
Breaking Medicine Technology: