Navigation Links
Worming our way to new treatments for Alzheimer's disease
Date:3/7/2013

Philadelphia, PA, March 7, 2013 According to a 2012 World Health Organization report, over 35 million people worldwide currently have dementia, a number that is expected to double by 2030 (66 million) and triple by 2050 (115 million). Alzheimer's disease, the most common form of dementia, has no cure and there are currently only a handful of approved treatments that slow, but do not prevent, the progression of symptoms.

New drug development, no matter the disease, is a slow, expensive, and risky process. Thus, innovative techniques to study and assess the possibilities of already-existing drugs for different diseases can be used to alleviate the traditional burdens of cost and time. Detailed in their new article in Biological Psychiatry, researchers from the University of Washington, led by Dr. Brian Kraemer, have developed an exciting new approach to screening potential new treatments for Alzheimer's disease using C. elegans, a small transparent worm.

Their focus was on tau, a protein involved in maintaining brain cell structure. In Alzheimer's disease and related disorders, tau protein becomes abnormally modified and forms clumps of protein called aggregates. These aggregates are a hallmark of the dying nerve cells in Alzheimer's disease and other related disorders. Diseases with abnormal tau are called tauopathies.

Dr. Kraemer's lab previously developed a worm model for tauopathy by expressing human tau in C. elegans nerve cells. This model has behavioral abnormalities, accumulates abnormal tau protein, and exhibits loss of nerve cellsall of which are general features of Alzheimer's disease.

Using their worm model for this study, they screened a library of 1,120 drugs approved for human use and tested each at three different concentrations to identify compounds that suppress the effects of abnormal tau aggregation.

"We have identified six compounds capable of reliably alleviating tau induc
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Global health researchers urge integrating de-worming into HIV care in Africa
2. Recon 2 modeling may help tailor treatments for patients with metabolic diseases, cancer
3. DNDi receives BBVA Foundation award for delivering new treatments for neglected diseases
4. Best Glaucoma Treatments Still a Puzzle, Task Force Reports
5. San Bruno, CA Dentist Dr. Bradley Parker Receives Top Reviews for New Laser Assisted Dental Treatments
6. ADHD Treatments Not Working for Most Young Children
7. Research fellowships to advance medical treatments and bring new science to market
8. 3 NIH-sponsored clinical trials test influenza treatments
9. World Stem Cells, LLC. facilitates Stem Cell Treatments In Cancun at World Stem Cells Clinic
10. Beware Fake Flu Treatments, FDA Warns
11. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces New Alternative to Stomach Botox Injections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- The United ... arriving from Ebola-affected nations of West Africa land ... them for infection with the virus. In ... Johnson noted that 94 percent of air passengers ... at one of these five airports -- New ...
(Date:10/22/2014)... Washington, D.C. (PRWEB) October 22, 2014 With ... November, a national survey by the American Institutes for Research ... they know how to use health insurance, but 42 percent ... review a plan’s details before signing up for coverage. , ... literacy, with only 20 percent able to calculate correctly how ...
(Date:10/22/2014)... Losing Weight Your Body’s Way , In a ... the face, it certainly can be difficult to choose the ... extra favor by doing it the healthy way? Set aside ... to your body, exercise regularly, and choose foods with the ... weight; you need to exercise more and eat less. Despite ...
(Date:10/22/2014)... 2014 Akeso Biomedical, Inc. , ... treatment of bacterial infections, microbial biofilms, and chronic wounds, ... board of directors. , Dr. Sinskey ... The Massachusetts Institute of Technology, or MIT. He has ... Dr. Sinskey also holds positions as Co-Director of the ...
(Date:10/22/2014)... Tara Haelle HealthDay Reporter ... drinking among young adult men may lead to increased blood ... didn,t cause a similar rise in blood pressure for young ... fact, when young adult women drank lightly or moderately, their ... study found. "This finding parallels studies in older adult ...
Breaking Medicine News(10 mins):Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4
... of death in Lake County , ... Evanston, IL (Vocus) March 12, ... a $1 million commitment to the Lake County Health Department and Community ... to addressing the steadily growing problem of diabetes in the county. , ...
... National Center for Creative Aging (NCCA) will feature certification on ... of the "NCCA-MetLife Foundation Creativity Matters: Health, Wellness, and ... March 30, 31, April 1 . Anne ... at the University of Wisconsin and Founder and ...
... Well-known for its preventive care initiatives, state,s largest ... American Lung Association to provide medical professionals the ... Live Well programCHARLESTON, W.Va., March 12 The ... UniCare Health Plan of West Virginia, Inc. (UniCare) ...
... finding and help fight obesity , , THURSDAY, March 12 (HealthDay ... may keep children more active and help combat the continued ... For every park found within a half-mile of home, a ... odds of taking part in leisure walking increased by 60 ...
... What,s Safe to Eat and Who,s Most At RiskLANSING, ... food safety legislation under debate in the U.S. Senate ... that Americans are more concerned than ever when it ... alarmingly unaware of the long-term side effects of Salmonella, ...
... the forthcoming 24th Annual EAU Congress in Stockholm (SE), which ... organizing three Meet the Expert sessions. These are press meetings ... in the Press Centre of the congress venue. In these ... the experts their questions practically one-on-one. , The first session,s ...
Cached Medicine News:Health News:NorthShore University HealthSystem Launches Diabetes Outreach Program for Lake County's Medically Underserved 2Health News:NorthShore University HealthSystem Launches Diabetes Outreach Program for Lake County's Medically Underserved 3Health News:NorthShore University HealthSystem Launches Diabetes Outreach Program for Lake County's Medically Underserved 4Health News:National Center for Creative Aging Features Timeslips in 'Creativity Matters' Symposium on Health, Wellness, and the Arts 2Health News:UniCare Health Plan of West Virginia Providing Assistance for Asthma Education Training 2Health News:UniCare Health Plan of West Virginia Providing Assistance for Asthma Education Training 3Health News:Kids Who Live Near Green Spaces Seem to Walk More 2Health News:Food Safety Expert: Americans Not Aware of Ongoing Risk & Complications of Salmonella Poisoning 2Health News:Food Safety Expert: Americans Not Aware of Ongoing Risk & Complications of Salmonella Poisoning 3Health News:Meet the expert sessions at the 24th Annual EAU Congress 2
(Date:10/22/2014)... Oct. 22, 2014 WHEN: Wednesday, October 29, ... registration available at: http://bit.ly/1yStiU9 SPEAKERS: ... and Visionary Innovation Research Group Senior Research ... self-assembling materials, nanobots and flexible electronics are ... transform our lives in the coming decades. ...
(Date:10/22/2014)... Conn. , Oct. 22, 2014  Recently published ... have bolstered the already substantial database of evidence. This ... adoption of Stretta therapy for sufferers of ... clinical evidence supporting Stretta therapy as a ... policies that make Stretta therapy available to nearly 50 ...
(Date:10/20/2014)... MOUNTAIN VIEW, California , 20 de octubre ... un líder en el campo de la pulmonología ... en su Estudio RENEW, casi 3 meses antes ... prueba fundamental de exención de dispositivo de investigación ... y Medicamentos) para el sistema de espiral de ...
Breaking Medicine Technology:Futuristic Technologies That Will Transform Our World Beyond 2030 2Futuristic Technologies That Will Transform Our World Beyond 2030 3Futuristic Technologies That Will Transform Our World Beyond 2030 4Recent Clinical Study Data Confirms Efficacy of Stretta Therapy - Spurs Additional Insurance Coverage and Financing Round 2PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3
... The Dual Media Set, different from ... Broth (LB) or other specially prepared medium, ... OVEREXPRESSION BROTH (OB). For cell expansion, E. ... the production of the recombinant protein is ...
...
0.3% Beef extract, 0.5% Peptone, 0.5 % Lactose....
... controls the temperature at your lab bench. This ... to 99 C*, with the "plus" being a ... C. The thermoblocks for 0.2 ml**, 0.5 ml, ... a high degree of flexibility for a multitude ...
Medicine Products: