Navigation Links
Worming our way to new treatments for Alzheimer's disease
Date:3/7/2013

Philadelphia, PA, March 7, 2013 According to a 2012 World Health Organization report, over 35 million people worldwide currently have dementia, a number that is expected to double by 2030 (66 million) and triple by 2050 (115 million). Alzheimer's disease, the most common form of dementia, has no cure and there are currently only a handful of approved treatments that slow, but do not prevent, the progression of symptoms.

New drug development, no matter the disease, is a slow, expensive, and risky process. Thus, innovative techniques to study and assess the possibilities of already-existing drugs for different diseases can be used to alleviate the traditional burdens of cost and time. Detailed in their new article in Biological Psychiatry, researchers from the University of Washington, led by Dr. Brian Kraemer, have developed an exciting new approach to screening potential new treatments for Alzheimer's disease using C. elegans, a small transparent worm.

Their focus was on tau, a protein involved in maintaining brain cell structure. In Alzheimer's disease and related disorders, tau protein becomes abnormally modified and forms clumps of protein called aggregates. These aggregates are a hallmark of the dying nerve cells in Alzheimer's disease and other related disorders. Diseases with abnormal tau are called tauopathies.

Dr. Kraemer's lab previously developed a worm model for tauopathy by expressing human tau in C. elegans nerve cells. This model has behavioral abnormalities, accumulates abnormal tau protein, and exhibits loss of nerve cellsall of which are general features of Alzheimer's disease.

Using their worm model for this study, they screened a library of 1,120 drugs approved for human use and tested each at three different concentrations to identify compounds that suppress the effects of abnormal tau aggregation.

"We have identified six compounds capable of reliably alleviating tau induc
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Global health researchers urge integrating de-worming into HIV care in Africa
2. Recon 2 modeling may help tailor treatments for patients with metabolic diseases, cancer
3. DNDi receives BBVA Foundation award for delivering new treatments for neglected diseases
4. Best Glaucoma Treatments Still a Puzzle, Task Force Reports
5. San Bruno, CA Dentist Dr. Bradley Parker Receives Top Reviews for New Laser Assisted Dental Treatments
6. ADHD Treatments Not Working for Most Young Children
7. Research fellowships to advance medical treatments and bring new science to market
8. 3 NIH-sponsored clinical trials test influenza treatments
9. World Stem Cells, LLC. facilitates Stem Cell Treatments In Cancun at World Stem Cells Clinic
10. Beware Fake Flu Treatments, FDA Warns
11. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces New Alternative to Stomach Botox Injections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... July 11, 2014 The report ... Specialty Nutrients, Animal Feed), Applications (Regular, Therapeutic, Preventive ... Global Trends & Forecasts to 2019 ” defines ... analysis and forecasting of the market value of ... the driving and restraining factors for the global ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Biostimulants are ... growth in turf and ornamentals. These also help turf ... improve length of roots. Turf, ornamentals, and flowers appear ... Therefore, this usage has increased from the last few ... turf and ornamentals is Europe, with around 40% share ...
(Date:7/11/2014)... and overweight firefighters are not receiving weight management ... new research from The University of Texas Health ... state that health care professionals (HCPs) should advise ... weight. Firefighters have high rates of obesity, and ... deaths in firefighters. This study assessed the association ...
(Date:7/11/2014)... Steven Reinberg HealthDay Reporter ... to protect children from the worldwide scourge of dengue fever ... While the vaccine only prevented dengue fever in 56 percent ... three shots, it protected more than 88 percent of them ... lead to hospitalization, and sometimes death. "This vaccine has ...
(Date:7/11/2014)... Riverside Health System became the first provider of ... late 2012 and now, in partnership with Williamsburg Landing, will ... Williamsburg and Newport News region. , Also known as life ... independent older adults who wish to remain in their homes ... continuing care services as well as control over the cost ...
Breaking Medicine News(10 mins):Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 2Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 3Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 4Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 5Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:Dengue Fever Vaccine Shows Some Promise in Trial 2Health News:Dengue Fever Vaccine Shows Some Promise in Trial 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 4
... sisters can be tough work, as any youngest child will tell ... of North Carolina at Chapel Hill shows that when it comes ... first born or rather, first laid siblings as well. ... ONE, runs somewhat counter to common wisdom, which holds that baby ...
... Angeles, March 12 --Combined positron emission tomography (PET) and ... more effective method to evaluate response to radiation therapy, ... study by researchers at the University of Southern California ... be published in the March issue of the journal ...
... Partnerships, MHA Keystone and other initiatives are featured, ... health care,professionals provide an inside look at how ... Shield of Michigan are,saving lives, improving patient care ... from the Blues., "These partnerships demonstrate the ...
... Interim Results from National Chronic Disease ... ... participants in the Diabetes Ten City Challenge (DTCC) improved across,all ... of,the program, the American Pharmacists Association (APhA) Foundation,announced today., ...
... Omnicell,Inc. (Nasdaq: OMCL ), a leading provider of ... has completed its $40.0,million program to repurchase shares of ... at an average price of $18.75., About Omnicell, ... leading provider of systems and,software solutions targeting patient safety ...
... ARAY ), a global leader in the field of ... American Medical,Devices Product of the Year award, from global ... Radiosurgery System., The Frost & Sullivan Award for ... company that has demonstrated excellence in new product,development and ...
Cached Medicine News:Health News:Early bird doesn't always get worm, UNC researcher finds 2Health News:USC researchers find benefit for lymphoma patients in combined PET-CT scanning 2Health News:Partnerships Report Highlights How Blue Cross Blue Shield of Michigan, Physicians and Hospitals Are Working to Save Lives, Improve Care, Reduce Costs 2Health News:Partnerships Report Highlights How Blue Cross Blue Shield of Michigan, Physicians and Hospitals Are Working to Save Lives, Improve Care, Reduce Costs 3Health News:Partnerships Report Highlights How Blue Cross Blue Shield of Michigan, Physicians and Hospitals Are Working to Save Lives, Improve Care, Reduce Costs 4Health News:Diabetes Ten City Challenge Collaborative Model Shows Improved Patient Health Across Key Clinical Indicators 2Health News:Diabetes Ten City Challenge Collaborative Model Shows Improved Patient Health Across Key Clinical Indicators 3Health News:Diabetes Ten City Challenge Collaborative Model Shows Improved Patient Health Across Key Clinical Indicators 4Health News:Omnicell Announces Completion of Its Common Stock Repurchase Plan 2Health News:Accuray's CyberKnife System Receives 2008 North American Medical Devices Product of the Year Award From Frost & Sullivan 2Health News:Accuray's CyberKnife System Receives 2008 North American Medical Devices Product of the Year Award From Frost & Sullivan 3
(Date:7/10/2014)... Yesterday, former Congressman Patrick Kennedy ... facility. Rep. Kennedy and Dick Moberg ... research in neurological disease and treatment. ... Garen Staglin , created One Mind, a ... that will radically accelerate the development and implementation ...
(Date:7/10/2014)... , July 10, 2014  Decision Resources ... surveyed infectious disease (ID) specialists are willing to ... Orbactiv (oritavancin) for use as OPAT, approximately two-thirds ... these agents to their hospital inpatients. However, our ... OPAT patients are initiated on OPAT following hospital ...
(Date:1/15/2014)... 2014 Sono-Tek Corporation (OTC BB: SOTK) today announced sales ... compared to sales of $2,202,000 for the prior year period, ... has also shown growth over the preceding quarter,s sales, continuing ... fiscal year. Markets that experienced sales increases over the prior ...
Breaking Medicine Technology:Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4
... ANN ARBOR, Mich., Oct. 12 Incept BioSystems, Inc. ... technology developed at the University of Michigan, announced today ... of its proprietary, SMART Start ™ Embryo Culture ... to the U.S. Food & Drug Administration ("FDA").  A ...
... with disabilities, their families, caregivers, seniors, wounded veterans and healthcare ... 15, through Sunday, October 17, 2010 at the Cobb Galleria ... Friday 11 am to 5 pm, Saturday 10 am to ... Abilities Expo has put together an impressive line-up of ...
Cached Medicine Technology:Incept BioSystems Completes First Human Clinical Trial of the SMART Start™ Embryo Culture System and Submits 510(k) Application to the FDA 2Incept BioSystems Completes First Human Clinical Trial of the SMART Start™ Embryo Culture System and Submits 510(k) Application to the FDA 3People With Disabilities Experience Their Possibilities at Abilities Expo in Atlanta, Georgia 2People With Disabilities Experience Their Possibilities at Abilities Expo in Atlanta, Georgia 3