Navigation Links
Worm study provides hope for deadly disease of the brain
Date:7/16/2014

LIVERPOOL, UK 17 July 2014: An untreatable and deadly neurodegenerative disease has been modelled and treated in worms by University of Liverpool researchers, suggesting a cure could be found for humans.

The scientists studied adult onset neuronal lipofuscinosis (ANCL) which usually strikes around 1 in 100,000 people in Europe and North America in their 30s and results in death by the mid-40s. There is currently no known treatment for this disease, though it has recently been identified as being caused by mutations in the gene called DNAJC5.

For the first time scientists, from the University's Institute of Translational Medicine, have replicated the disease in nematode worms and successfully treated it with a drug called resveratrol.

The worms have a gene called dnj-14 which is their version of the human DNAJC5. Since the worms lifespan is normally only a few weeks, the symptoms of the disease show within a few days and this opens up the possibility of testing thousands of new compounds for treatment within a short period of time hastening the development of a cure.

One compound, resveratrol, has already been shown by the research team to be effective in treating the disease and in a way not previously seen without the need to act through an enzyme produced in the body called SIR-2.1.

Physiologist, Professor Alan Morgan led the study. He said: "ANCL is fortunately rare but it is currently untreatable. This research allows us to quickly test compounds which could be used for treatment. Of the first batch of compounds we used in testing our model, one has already shown encouraging effects."

Professor Morgan and his colleagues Professor Bob Burgoyne and PhD student, Sudhanva Kashyap now plan to test more compounds with the model and to explore how nematode worms can be used to study more neurodegenerative diseases.

Professor Morgan concluded: "As we face an increasingly ageing population, having treatments for these conditions becomes ever more critical. Studying how these diseases work in a simple organism which is easy and cheap to breed, can speed up the process of developing effective drugs."


'/>"/>

Contact: Jamie Brown
jamie.brown@liverpool.ac.uk
44-151-794-2248
University of Liverpool
Source:Eurekalert

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... ... February 19, 2017 , ... "At your fingertips" electronic ... MEDfx and the Delaware Health Information Network (DHIN) have partnered to improve connectivity ... state-wide health information exchange, DHIN stores and shares real-time health data for more ...
(Date:2/18/2017)... (PRWEB) , ... February 17, 2017 , ... ... , drvallecillos.com , Beverly Hills plastic surgeon Dr. Glenn Vallecillos ... cells. , Dr. Vallecillos says, "Traditionally, plastic surgery has been centered around that ...
(Date:2/17/2017)... ... February 17, 2017 , ... While EHR data ... has introduced an innovative workstation designed to reduce nursing fatigue while enhancing productivity. ... EHR Workstation offers a lightweight, highly mobile, multi-functional alternative to the limitations of ...
(Date:2/17/2017)... ... February 17, 2017 , ... Empowering ... Francis' goals for each and every seminar, session and class she offers. ... five different brainwave tools which help energize creativity, focus mental functions, enhance athletic ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... ... cycle management services, announced today that Karen Pilley has been promoted to Chief ... critical in today’s shifting healthcare paradigm – a shift that demands the transition ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... , Feb. 16, 2017 Quest Diagnostics (NYSE: ... diagnostic information services, today announced that it has been ... 2017 by Fortune. The annual survey ... in the "Health Care: Pharmacy and Other Services" industry ... information services company to attain the designation. This is ...
(Date:2/16/2017)... 2017 The Lockwood Group (Lockwood), a medical communications ... Work in Connecticut list by the ... in a row that Lockwood has been in the top ... number-two spot in 2017. The award recognizes companies that have ... were determined through a survey conducted by The Best Companies ...
(Date:2/16/2017)... 16, 2017 Summary Provides understanding and ... the worlds leading healthcare companies. ... Description The Global Allergy Partnering Terms and Agreements ... agreements entered into by the world,s leading healthcare companies. ... value - Deals listed by company A-Z, industry sector, stage ...
Breaking Medicine Technology: