Navigation Links
Worm studies shed light on human cancers
Date:4/21/2011

MADISON -- Research in the worm is shedding light on a protein associated with a number of different human cancers, and may point to a highly targeted way to treat them.

University of Wisconsin-Madison scientists were studying a worm protein called TFG-1, which is present in many cell types but whose exact role had never been understood. The scientists discovered that the protein controls key aspects of the movement, or secretion, of growth factors out of cells.

"TFG-1 has never been implicated in the secretory process before," says Dr. Anjon Audhya, an assistant professor of biomolecular chemistry in the School of Medicine and Public Health. "It turns out that humans carry a very similar protein, and we think it plays the same role in humans as in worms."

Reviewing the scientific literature, the researchers found that the gene encoding TFG in humans is fused to at least three other genes implicated in anaplastic large cell lymphoma, papillary thyroid carcinoma and extraskeletal chondrosarcoma. The fusions occur when two broken or rearranged pieces of DNA combine to form a "chimeric" gene with completely distinct properties.

Audhya's studies of TFG-1 in the worm led him to develop a model that explains how TFG fusions may stimulate cancer in humans. As reported in the current issue of Nature Cell Biology (Advanced Online Publication), he proposes that abnormal levels of growth factor secretion may produce a rich micro-environment that helps tumors form and thrive. "We think certain properties of TFG lead it to be a very effective precursor oncogene," he says.

Normally, a growth factor primed to leave a cell is encompassed by a sac, or vesicle, and then transported from one structure inside the cell to anotherendoplasmic reticulum (ER) to Golgibefore it leaves the cell and discharges into the extracellular space.

Through their genetic studies, the Wisconsin researchers found
'/>"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-261-1034
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UC studies show marijuana has therapeutic value, reports to legislature
2. Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies
3. Studies Detail Possible Benefits of omega-3 Fatty Acids for Dogs With Arthritis
4. COPPERTONE(R) Solar Research Center Unveils Studies on Efficacy of Topical Antioxidants in Sunscreens at 2010 Annual Meeting of The American Academy of Dermatology
5. Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies
6. Most Drug Studies Dont Help Docs Pick Best Treatment
7. Gays, Lesbians Excluded From Some Medical Studies
8. Studies Show Significant Increases of C. Difficile Infections (CDI)
9. Studies examine Third Eye Retroscope during colonoscopy
10. Statement of Ralph B. Everett, President and CEO, Joint Center for Political and Economic Studies, on House Passage of Health Reform Legislation
11. New studies on surgical options in inherited breast cancer show drastic treatment is not always best
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... August 03, 2015 , ... They know every second counts. And when it ... offers some of the best care in the nation. For the past two months, ... average blood clot removal time in the country. During the months of June and ...
(Date:8/3/2015)... Angeles, California (PRWEB) , ... August 03, 2015 ... ... Fifth Circuit Court of Appeals ruled in favor of the firm’s client Rebecca ... ), North Cypress Medical Center must reimburse benefits for Hamsher’s residential treatment for ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... researchers from the University of Pittsburgh School of Medicine are leading a five-year, ... drugs in sub-Saharan Africa. , A cooperative agreement awarded by the U.S. ...
(Date:8/3/2015)... ... August 03, 2015 , ... Novation, the nation’s largest healthcare ... lab testing and precision medicine solutions that can help pharmacists and other healthcare ... than 8.6 million adverse drug events are reported in the U.S. Pharmacogenetic ...
(Date:8/3/2015)... ... August 03, 2015 , ... Catalent Pharma ... drugs, biologics and consumer health products, today welcomed the announcement by OPKO Health ... Drug Application for a new treatment for chronic kidney disease (CKD) and vitamin ...
Breaking Medicine News(10 mins):Health News:Providence St. Vincent Stroke Care Recognized Among Best in the Country 2Health News:Providence St. Vincent Stroke Care Recognized Among Best in the Country 3Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 2Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 3Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 2Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 3Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 4Health News:Novation Awards Genelex First Group Purchasing Agreement for Pharmacogenetic Testing and Precision Medicine Software 2Health News:Novation Awards Genelex First Group Purchasing Agreement for Pharmacogenetic Testing and Precision Medicine Software 3Health News:Catalent’s OptiShell™ Technology is Delivery Platform for OPKO Health’s New Chronic Kidney Disease Treatment 2Health News:Catalent’s OptiShell™ Technology is Delivery Platform for OPKO Health’s New Chronic Kidney Disease Treatment 3
... 5, 2011More mothers are breastfeeding their newborns, but for ... of breastfeeding for both mothers and infants. New observations ... breastfeed longer are presented in a collection of articles ... the Academy of Breastfeeding Medicine, published by Mary Ann ...
... By Lisa Esposito HealthDay Reporter , MONDAY, ... -- sending suggestive or explicit images by cellphone or ... Only a small minority of children reports transmitting ... than the rule, researchers say. In the ...
... (HealthDay News) -- A new study finds abuse in childhood ... research found that teens who,ve been abused or neglected have less ... some areas of the brain than those who haven,t been subjected ... history of abuse or neglect. They also had reductions of gray ...
... MONDAY, Dec. 5 (HealthDay News) -- When people with type ... third worrisome condition -- dementia -- goes up markedly, ... diabetes are twice as likely to develop dementia three to ... people with diabetes, researchers found. "We,ve known for years ...
... at Moffitt Cancer Center and colleagues have found that patients ... years after their therapy. The new study, published in the ... a follow-up to a study on fatigue and chemotherapy and ... in 2007. "Fatigue is among the most common ...
... MONDAY, Dec. 5 (HealthDay News) -- About one in ... according to new research. That number is up from ... Preventive asthma medications help control the airway disease before ... Education and Prevention Program recommend their use. "The ...
Cached Medicine News:Health News:Mothers are not reaching breastfeeding goals -- what needs to change? 2Health News:Teen 'Sexting' Might Be Less Common Than Feared 2Health News:Teen 'Sexting' Might Be Less Common Than Feared 3Health News:Abuse in Childhood May Alter Teen Brain 2Health News:Risk for Dementia Rises When Diabetes, Depression Meet: Study 2Health News:Risk for Dementia Rises When Diabetes, Depression Meet: Study 3Health News:Follow-up study finds prolonged fatigue for those who had chemotherapy for breast cancer 2Health News:More Children Using Preventive Asthma Drugs: Study 2Health News:More Children Using Preventive Asthma Drugs: Study 3
(Date:8/3/2015)... -- ReportsnReports.com adds Global Medical Simulation ... as well as Global Medical Simulation Market 2015-2019 ... of its library. Complete 2015 report ... across 164 pages, talking about 7 major companies ... now available at http://www.reportsnreports.com/reports/407046-global-medical-simulation-industry-report-2015.html . ...
(Date:8/3/2015)... , Aug. 3, 2015  Depomed, Inc. (NASDAQ: ... Horizon Pharma plc,s (NASDAQ: HZNP ) ("Horizon") announcement ... Directors ("Depomed Board") set a record date to determine ... The Depomed Board will review the request ... received today and contains the information required under Depomed,s ...
(Date:8/3/2015)... Va. , Aug. 3, 2015  Dr. ... joining Orthopaedic & Spine Center today, ... to manage their chronic pain through psychological counseling ... is a Fellowship-trained, certified medical psychologist with ... medicine. His vast experience ranges from assessment and ...
Breaking Medicine Technology:Medical Simulation Market to see 14% CAGR to 2019 2Medical Simulation Market to see 14% CAGR to 2019 3Medical Simulation Market to see 14% CAGR to 2019 4Medical Simulation Market to see 14% CAGR to 2019 5Medical Simulation Market to see 14% CAGR to 2019 6Depomed Comments on Horizon Pharma Announcement 2Depomed Comments on Horizon Pharma Announcement 3Depomed Comments on Horizon Pharma Announcement 4Depomed Comments on Horizon Pharma Announcement 5Depomed Comments on Horizon Pharma Announcement 6Orthopaedic & Spine Center Introduces New Pain Psychologist 2
... Diagnostics Incorporated (NYSE: DGX ), the world,s leading ... its Board of Directors declared a quarterly cash dividend of ... of record of Quest Diagnostics common stock on April 3, ... Quest Diagnostics is the world,s leading provider of diagnostic testing, ...
... 28, 2012 HistoRx, the leader in quantitative ... technology and critical elements of digital microscopy standardization.  ... the US Patent & Trademark Office advance the ... pathology to a dominant role in the industry.  ...
Cached Medicine Technology:HistoRx Achieves Dominant Intellectual Property Position in Standardization of Results from Digital Pathology Instruments 2HistoRx Achieves Dominant Intellectual Property Position in Standardization of Results from Digital Pathology Instruments 3
Human based assayed sera available in three levels for the control of accuracy and precision for up to 25 analytes...
The AMY method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of amylase activity in serum, plasma and urine....
For the quantitative in vitro determination of Aspartate Aminotransferase (AST) in serum and plasma....
This is an Immunological assay intended for the quantitative in vitro determination of haemoglobin A1c (HbA1c) in whole blood....
Medicine Products: