Navigation Links
Worm Therapy Shows Promise for Ulcerative Colitis
Date:12/1/2010

By Julia VanTine
HealthDay Reporter

WEDNESDAY, Dec. 1 (HealthDay News) -- The case of a man who swallowed parasite eggs to treat his ulcerative colitis -- and actually got better -- sheds light on how "worm therapy" might help heal the gut, a new study suggests.

"Our findings in this case report suggest that infection with the eggs of the T. trichiura roundworm can alleviate the symptoms of ulcerative colitis," said study leader P'ng Loke, an assistant professor in the department of medical parasitology at NYU Langone Medical Center. A human parasite, Trichuris trichiura infects the large intestine.

The findings could also lead to new ways to treat the debilitating disease, a form of inflammatory bowel disease (IBD) currently treated with drugs that don't always work and can cause serious side effects, said Loke.

The study findings are published in the Dec. 1 issue of Science Translational Medicine.

Loke and his team followed a 35-year-old man with severe colitis who tried worm (or "helminthic") therapy to avoid surgical removal of his entire colon. He researched the therapy, flew to a doctor in Thailand who had agreed to give him the eggs, and swallowed 1,500 of them.

The man contacted Loke after his self-treatment and "was essentially symptom-free," Loke said. Intrigued, he and his colleagues decided to follow the man's condition.

The study analyzed slides and samples of the man's blood and colon tissue from 2003, before he swallowed the eggs, to 2009, a few years after ingestion. During this period, he was virtually symptom-free for almost three years. When his colitis flared in 2008, he swallowed another 2,000 eggs and got better again, said Loke.

Tissue taken during active colitis showed a large number of CD4+ T-cells, which are immune cells that produce the inflammatory protein interleukin-17, the team found. However, tissue taken after worm therapy, when his colitis was in remission, contained lots of T-cells that make interleukin-22 (IL-22), a protein that promotes wound healing.

Further, after worm therapy, the man's colon produced significantly more mucus, said Loke, who noted that a lack of mucus in the colon is linked with severe symptoms. "We think the worms increase or restore mucus production in the colon," he said. "Basically, the gut is trying to expel the worms. This increase in mucus may play a role in relieving the symptoms."

"This is not the usual clinical trial, but you take your opportunities for unique observation where you can," said Dr. Gerald W. Dryden Jr., director of the clinical research division of gastroenterology, hepatology and nutrition at the University of Louisville, in Kentucky.

Before this study, IL-22 had not been associated with beneficial effect in IBD, said Dryden. "While it doesn't determine cause-and-effect, the study does seem to demonstrate an important, previously unknown association between IL-22 and response to helminthic therapy," he said.

Causing abdominal pain, diarrhea and other symptoms, colitis affects about 700,000 Americans, according to the Crohn's and Colitis Foundation of America. Scientists don't know what causes the disease, but theorize that immune-system dysfunction plays a role.

Colitis is common in developed countries such as America -- where parasitic worm infections are rare -- and in Asia, Africa and Latin America, where virtually the entire population is infected, the study noted. Clinical trials with the pig whipworm Trichuris suis have improved the symptoms of both ulcerative colitis and Crohn's disease, and animal studies suggest that various parasitic worms can suppress inflammation, the study noted.

The study also suggests new, worm-based treatments for both ulcerative colitis and IBD. Research might identify molecules derived from worms that suppress inflammation, or pathways activated by worms that can be targeted by more conventional approaches, Loke said.

Right now, however, worm therapy is still not well-understood and could potentially backfire, the study warned. "The problem is that these worms themselves can cause harm and damage the gut," said Loke. "The individual in this study is lucky to have responded so well, but for other people the worm infection may exacerbate bowel inflammation." Studies that use the pig worm, which should pose less risk to humans, are under way, he added.

More information

For more about ulcerative colitis, head to the U.S. National Digestive Diseases Information Clearinghouse.

SOURCES: P'ng Loke, assistant professor, department of medical parasitology, NYU Langone Medical Center, New York City; Gerald W. Dryden Jr., director, clinical research division, gastroenterology, hepatology and nutrition, University of Louisville, Kentucky; Dec. 1, 2010, Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Sixth global conference on stem cell therapy to be held Jan. 20-21, 2011, in New York City
2. Breast Cancer Rates Lower With Less Hormone Therapy: Study
3. Drop in breast cancer rates directly tied to reduced hormone therapy
4. Gene therapy prevents memory problems in mice with Alzheimers disease
5. Gene therapy for metastatic melanoma in mice produces complete remission
6. Neuralstem files FDA application for first drug therapy
7. Combination therapy improves survival time for patients with advanced liver cancer
8. Gene Therapy Shows Potential Against Heart Failure
9. Hearing loss common following radiation therapy for head and neck cancer
10. Targeted therapy reactivates guardian of the genome in resistant cancer
11. GUMC: fMRI predicts outcome to talk therapy in children with an anxiety disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Worm Therapy Shows Promise for Ulcerative Colitis
(Date:5/26/2016)... ... 26, 2016 , ... The Woodlands at John Knox Village , Florida’s ... care for living and healing, celebrated its grand opening, today. The Woodlands at John ... provided by Empowered Staff. , “This is an incredibly fulfilling time for John Knox ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... for the Foundation Fighting Blindness, Long Island Chapter on June 4, 2016, 1:30-3:30 ... , Dr. Maisel, founder of Retina Group of New York , is ...
(Date:5/26/2016)... Wash. (PRWEB) , ... May 26, 2016 , ... ... trusted provider of comprehensive treatment for eating disorders, is opening a brand new ... will provide individuals ages 8-17 and their families with even more specialized eating ...
(Date:5/26/2016)... Miami, FL (PRWEB) , ... May 26, 2016 , ... ... day of events featuring guest speaker Dr. Adonis Maiquez MD, ABAARM. Dr. Adonis ... Anti-Aging and Regenerative Medicine, and a member of the Institute for Functional Medicine. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... On May 23rd during the National Eye ... and international water advocate, was honored by Ashram, Inc. as the world’s foremost water ... knelt on the banks of the Nile to fill their red clay pots with ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016   ... endpoints demonstrating non-inferiority in overall bowel cleansing and superiority ... c leansing of the ... http://photos.prnewswire.com/prnh/20130829/633895-a ) , Norgine B.V. today announced new ... litre PEG and ascorbate bowel preparation) versus standard 2 litre PEG ...
(Date:5/24/2016)... -- Joe Marziani has joined VMS BioMarketing as senior vice president of sales, announced ... role, Marziani will lead the company,s business development and sales team, exploring new opportunities ... Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical ... and treat patients on a global scale. Medical professionals from ... Asia and the US have already signed up for ... in a totally secure environment. Education  "Imagine ... together with a surgeon at Harvard to treat a bomb victim ...
Breaking Medicine Technology: