Navigation Links
World's largest DNA scan for autism uncovers new gene variant for disorder
Date:4/28/2009

ccurred more frequently in autistic children than in the control group. These variants sat on chromosome 5 between two genes, CDH9 and CDH10.

In the second half of the study, the UCLA team looked at the two genes' presence in the developing human brain. While CDH9's presence appeared minimal, the scientists discovered that CDH10 was most active in the fetal brain's frontal cortex, a region critical to language, social behavior and complex thought processes such as judgment.

"This is a landmark finding," Geschwind said. "It's no coincidence that a gene linked to autism has a higher concentration in key brain regions that regulate speech and the ability to interpret social interaction. Our research suggests that CDH10 is switched on at a very early stage and plays an important role in regulating the developing brain. This prenatal activity somehow makes the infant more susceptible to autism."

By influencing the development of important brain structures, CDH10 provides a tangible link between genes, brain circuitry and a child's future behavior, Geschwind noted. The discovery also opens up a number of intriguing next steps for research, including the possibility of an imaging study to explore whether the gene behaves differently in the autistic brain.

The DNA samples and clinical data were provided by families who donated blood to the Los Angelesbased Autism Genetic Resource Exchange (AGRE), a program created and funded by Cure Autism Now, which merged with Autism Speaks in 2007.

"When parents like me first formed AGRE, this was our dream, that talented scientists would use our gene bank to collaborate and bring us closer to understanding autism," said Jon Shestack, co-founder of Cure Autism Now and a board member of Autism Speaks. "AGRE has played an important role in almost every major autism genetics paper in the past five years."

Autism is a complex brain disorder that strikes in early childhood. The condit
'/>"/>

Contact: Roxanne Moster
rmoster@mednet.ucla.edu
310-794-2264
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gunther Von Hagens BODY WORLDS and KORPERWELTEN - Not Affiliated With Paris Copycat Display
2. BODY WORLDS Exhibition Uses Lung Specimens to Launch Anti-Smoking Campaign at the San Diego Natural History Museum
3. HHS AIDS.gov to Use Blogs, Virtual Worlds, and Social Networks to Deliver HIV Information for World AIDS Day 2008
4. Gunther von Hagens BODY WORLDS Exhibitions Welcome Specimens From Worlds First Living Body Donor for Plastination
5. Gunther Von Hagens BODY WORLDS Exhibitions Mark 25th Million Visitor Milestone
6. California Science Center Welcomes 1-Millionth BODY WORLDS Visitor
7. Specimens in BODY WORLDS Exhibitions Stem Primarily from German Body Donation Program
8. The Institute for Plastination Responds to the Bishop of Manchesters Media Blitz, Assertions, and Allegations About BODY WORLDS Anatomical Exhibition Coming to Manchester
9. Museum Open Around the Clock - BODY WORLDS 2 and The Tech Host 40 Hour Marathon!
10. BODY WORLDS 3 & The Story of the Heart Opens at the California Science Center, March 14, 2008
11. BODY WORLDS 2 & Breathe California Pair Up for Some Ash Kicking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... "As a nurse, patients always ask me ... inventor from Tamaqua, Pa. "The reason that they cannot tell ... their chairs. My invention enables them to check oxygen levels ... to make it easier to monitor the contents of an ... the tank is low. It allows changeovers to be performed ...
(Date:9/20/2014)... 2014 Earlier this week, Home Depot revealed ... had their credit card information pilfered by hackers, surpassing the ... of headline articles like this one published by ... opening numbers. , “Most people tend to focus on ... a way to score a game,” says Joe Caruso, founder ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 Final Cut ... announced the release of the Information theme for FCPX filmmakers. ... use to describe the Information theme,” says Christina Austin, CEO ... to look so professional.” , Information features easy to use ... parameters of the environment. Change the background color, color of ...
(Date:9/20/2014)... “Motherhood is a wonderful gift and a huge responsibility,” ... article , “We know that you want to care for ... want to do as well.” , The article explains to ... their Family Physicians who practice obstetrics while pregnant, during delivery, ... To learn more about Community Health Center of Snohomish County ...
(Date:9/19/2014)... Nearly 780 Risperdal lawsuits are moving forward in ... took place to discuss the next steps in ... mass tort program. Attorneys for the plaintiffs and defendants ... Complex Litigation Center in Philadelphia’s City Hall where the ... lawsuits filed against Johnson & Johnson and its subsidiary, ...
Breaking Medicine News(10 mins):Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:Today Pixel Film Studios Announced the Release of the Information Theme for Final Cut Pro X 2Health News:Newest Article from Community Health Center of Snohomish County Highlights The Importance of Proper Health Care for Expectant Mothers 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 3Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 4
... researchers at Duke University Medical Center and the Universit catholique ... important energy source for tumor cells. In further experiments, they ... tumor cells by preventing them from delivering lactic acid. ... that low-oxygen, or hypoxic, cells cause resistance to radiation therapy," ...
... Therapeutics Inc., a leader,in the development of predictive ... funding to expand the development and commercialization of,ChemoFx(R). ... physicians select the,most effective chemotherapeutic regimen for cancer ... the round and was joined by existing,investors Adams ...
... ALEXANDRIA, Va., Nov. 20 Yesterday, America,s Health Insurance ... decided to support an "individual mandate," which requires everyone ... with "guaranteed issue," meaning that everyone must be accepted ... , But the Council for Affordable Health ...
... KANSAS CITY, Mo., Nov. 20 An investor group in ... developer and manufacturer of,diagnostic products whose shares are traded in ... Clint Severson has joined the company,s,board of directors. , ... Reidy stated, "We are delighted that Clint has,agreed to serve ...
... relatives at risk for hospital visits of their own , , ... care for a loved one with Alzheimer,s results in 25 ... or hospital visit every six months, says an Indiana University ... of an Alzheimer,s patient is difficult, but the Indiana University ...
... infection that can cause meningitis, pneumonia in young children, ... officials said Thursday that a shortage of vaccine is ... most important causes of bacterial illness in young children. ... increase in cases, the stepped-up surveillance was prompted by ...
Cached Medicine News:Health News:Lactic acid found to fuel tumors 2Health News:Precision Therapeutics Secures $43 Million in Venture Capital Funding 2Health News:Precision Therapeutics Secures $43 Million in Venture Capital Funding 3Health News:CAHI Stands by Its Principles for Health Insurance Reform 2Health News:Investor Group Commends Clint Severson for Joining Trinity Biotech's Board of Directors 2Health News:When the Caregiver Becomes the Patient 2Health News:CDC Monitors Shortage of Hib Vaccine 2Health News:CDC Monitors Shortage of Hib Vaccine 3
(Date:9/19/2014)... 19, 2014  Diplomat, the nation,s largest independent specialty ... to the Board of Directors on September 15, ... also serve as chair of the Audit Committee. ... accounting, financial, compliance and operating experience in the health ... as chief financial officer, chief operating officer and secretary ...
(Date:9/19/2014)... According to market research ... Industrial, & Laboratory), Industry (Food, Pharmaceutical, Biotechnology, Surgical ... & Geography - Global Trends & Forecast to ... lyophilization market on the basis of various types, ... the market size of each of these segments ...
(Date:9/19/2014)... -- BioSpecifics Technologies Corp. (NASDAQ: BSTC ), a biopharmaceutical ... ® in the U.S. and XIAPEX ® in ... , will present a corporate overview at the 21 st ... The presentation will take place on Friday, September ... Hotel in New York, NY . A ...
Breaking Medicine Technology:David Dreyer Appointed to Diplomat Board of Directors 2Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2
... a quadriplegic triathlete, has been named spokesperson for National ... with disabilities to live active, mobile lifestyles. The goal ... well as the many other transportation solutions that can ... those with disabilities. Savicki is a proud partner along ...
... In the Middle East and North Africa ... MENA region are among the top 10 globally with the ... Bahrain, Egypt, Kuwait, Oman and Saudi Arabia. The region spends ... its total health care expenditure and expenditure averages as high ...
Cached Medicine Technology:69-Time Gold Medalist and Multi-Sport Wheelchair Athlete Named Spokesperson for National Mobility Awareness Month 269-Time Gold Medalist and Multi-Sport Wheelchair Athlete Named Spokesperson for National Mobility Awareness Month 3Meeting of the Region's Top Diabetes Experts in Dubai this March 2
Shandon Plastic Slide Boxes...
Shandon Cardboard Slide Folders...
... The new Propaq LT is the ... environment--combining the basic parameters of continuous vital ... new design, making it perfect for just ... place. , Light enough to clip on ...
Exxcel Soft ePTFE vascular graft, designed for exceptional kink resistance and crush resistance, maintains a Soft touch for easier handling during peripheral vascular bypass procedures and vascular a...
Medicine Products: