Navigation Links
World's fastest camera, created by UCLA engineers, used to detect rogue cancer cells

The ability to distinguish and isolate rare cells from among a large population of assorted cells has become increasingly important for the early detection of disease and for monitoring disease treatments.

Circulating cancer tumor cells are a perfect example. Typically, there are only a handful of them among a billion healthy cells, yet they are precursors to metastasis, the spread of cancer that causes about 90 percent of cancer mortalities. Such "rogue" cells are not limited to cancer they also include stem cells used for regenerative medicine and other cell types.

Unfortunately, detecting such cells is difficult. Achieving good statistical accuracy requires an automated, high-throughput instrument that can examine millions of cells in a reasonably short time. Microscopes equipped with digital cameras are currently the gold standard for analyzing cells, but they are too slow to be useful for this application.

Now, a new optical microscope developed by UCLA engineers could make the tough task a whole lot easier.

"To catch these elusive cells, the camera must be able to capture and digitally process millions of images continuously at a very high frame rate," said Bahram Jalali, who holds the Northrop Grumman Endowed Opto-Electronic Chair in Electrical Engineering at the UCLA Henry Samueli School of Engineering and Applied Science. "Conventional CCD and CMOS cameras are not fast and sensitive enough. It takes time to read the data from the array of pixels, and they become less sensitive to light at high speed."

The current flow-cytometry method has high throughput, but since it relies on single-point light scattering, as opposed to taking a picture, it is not sensitive enough to detect very rare cell types, such as those present in early-stage or pre-metastasis cancer patients.

To overcome these limitations, an interdisciplinary team of researchers led by Jalali and Dino Di Carlo, a UCLA associate professor of bioengineering, with expertise in optics and high-speed electronics, microfluidics, and biotechnology, has developed a high-throughput flow-through optical microscope with the ability to detect rare cells with sensitivity of one part per million in real time.

This technology builds on the photonic time-stretch camera technology created by Jalali's team in 2009 to produce the world's fastest continuous-running camera.

In the latest issue of the journal Proceedings of the National Academy of Sciences, Jalali, Di Carlo and their colleagues describe how they integrated this camera with advanced microfluidics and real-time image processing in order to classify cells in blood samples. The new blood-screening technology boasts a throughput of 100,000 cells per second, approximately 100 times higher than conventional imaging-based blood analyzers.

"This achievement required the integration of several cutting-edge technologies through collaborations between the departments of bioengineering and electrical engineering and the California NanoSystems Institute and adds to the significant technology infrastructure being developed at UCLA for cell-based diagnostics," Di Carlo said.

Both Jalali and Di Carlo are members of the California NanoSystems Institute at UCLA.

Their research demonstrates real-time identification of rare breast cancer cells in blood with a record low false-positive rate of one cell in a million. Preliminary results indicate that this new technology has the potential to quickly enable the detection of rare circulating tumor cells from a large volume of blood, opening the way for statistically accurate early detection of cancer and for monitoring the efficiency of drug and radiation therapy.

"This technology can significantly reduce errors and costs in medical diagnosis," said lead author Keisuke Goda, a UCLA program manager in electrical engineering and bioengineering.

The results were obtained by mixing cancer cells grown in a laboratory with blood in various proportions to emulate real-life patient blood.

"To further validate the clinical utility of the technology, we are currently performing clinical tests in collaboration with clinicians," said Goda, also a member of the California NanoSystems Institute. "The technology is also potentially useful for urine analysis, water quality monitoring and related applications."


Contact: Wileen Wong Kromhout
University of California - Los Angeles

Related medicine news :

1. Human model of Huntingtons disease created from skins stem cells
2. All cancer cells are not created equal
3. Skin contact breast tumor detection
4. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
5. Danish scientists detect new immune alert signal
6. Super-sensitive tests could detect diseases earlier
7. Studies See Advances in Detecting, Treating Pancreatic Cancer
8. Colonoscopy May Detect Curable Cancer in Elderly: Study
9. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
10. PSA screening to detect prostate cancer can be beneficial to younger and at-risk men
11. Mammograms Beat Thermography for Breast Cancer Detection: Study
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
Breaking Medicine Technology: