Navigation Links
World-first discovery could help treat life-threatening tumors
Date:4/16/2008

WA researchers investigating how blood vessel growth keeps cancers alive have made a world-first discovery that could boost the chances of successfully treating life-threatening tumours.

Western Australian Institute for Medical Research (WAIMR) Associate Professor Ruth Ganss and her team have found that a gene called RGS5 can reverse angiogenesis the growth of blood vessels inside the tumour.

The discovery is published in the most recent edition of Nature, one of the worlds most prestigious scientific journals.

Its the uncontrolled growth of blood vessels and the formation of abnormal blood vessels inside tumours that feed them, allowing them to grow and stopping the immune system from wiping out the tumour, said Associate Professor Ganss.

What weve shown is that RGS5 is a master gene in angiogenesis and that when it is removed, angiogenesis reverses and the blood vessels in tumours appear more normal.

Importantly, this normalisation changes the tumour environment in a way that improves immune cell entry, meaning tumours can be destroyed and improving survival rates in laboratory tests.

Reversing abnormal vessel growth represents a fresh approach to tackling angiogenesis, with most current research focusing on how to block or kill tumour-feeding blood vessels.

Weve long-suspected this research would deliver advances in knowledge about what impacts tumour growth and this publication recognises the innovation and importance of our work, said Associate Professor Ganss.

By understanding what is actually going on in the tumour itself, the ultimate hope is that well be able to work on making current therapeutic approaches even more successful and reducing side effects of them.

Associate Professor Ganss breakthrough comes after joining WAIMR from Heidelberg where she worked at the German Cancer Research Center. Last month, The Cancer Council Western Australia granted Associate Professor Ganss a Cancer Council Research Fellowship for continued work into tumour angiogenesis.

The majority of the discovery was funded by the National Health and Medical Research Council and part of the work was achieved using facilities at The University of WA based Centre for Microscopy, Characterisation and Analysis.

Earlier this month, a second paper by Associate Professor Ganss and her team was published in The Journal of Clinical Investigation which describes how tumours can be attacked by the immune system with fewer side-effects.

This discovery involves targeting tumours with inflammatory substances that change the environment, so immune cells can attack the tumour through blood vessels more effectively and lessen the amount of toxins going elsewhere in the body, Associate Professor Ganss said.

WAIMR Director Professor Peter Klinken praised Associate Professor Ganss team saying their work was serving to further put WA on the scientific world map.

This breakthrough is one of the most significant discoveries to come out of WAIMR. The potential for this new knowledge to positively impact the lives of cancer patients in the future is very exciting, he said.

The fact that this breakthrough has come during our 10-year anniversary celebrations is just fantastic.


'/>"/>

Contact: Sarah Hayward
sarah@capturemedia.com.au
61-893-889-280
Research Australia
Source:Eurekalert

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Stem cell research produces a key discovery for Fragile X Syndrome
4. Welch Foundation gives $1.6 million for drug discovery research
5. New discovery leaves blood-doping athletes scratching their heads
6. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
7. New discovery leaves blood-doping athletes scratching their heads
8. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
9. Discovery supports theory of Alzheimers disease as form of diabetes
10. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
11. New discovery may improve treatment of one of the worlds leading causes of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... ... advisory organization, is proud to announce it has added CXC Solutions (CXC) as ... management solutions. These solutions are tailored to help benefits advisors reduce operating ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... portal for all the knowledge resources, including white papers, guides, handbooks, case studies, ... , To access more than 9,000 documents, webinars and videos available online, ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana Sibirskaya: A Life ... story of sacrifice and enlightenment. , “Tatiana Sibirskaya: A Life Devoted ... looking for creative outlets, Carolyn gravitated toward writing through the inspiration of her ...
(Date:12/6/2016)... ... December 06, 2016 , ... U.S. Security Associates (USA) ... 125 for their industry leading training methods that engage their associates and link ... the global elite in employer-sponsored training and development programs. , “The 2017 Training ...
(Date:12/5/2016)... ... December 06, 2016 , ... For many years, Andrew G. Zubinas ... thin. The beauty of the Lithuanian language and its poetry inspired him ... book, Zubinas lyrically explores all aspects of a living, breathing forest where nothing ever ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 2016  CVS Health, the nation,s largest pharmacy innovation ... score of 100 percent on the Corporate Equality Index ... an annual national benchmarking survey and report on corporate ... the Human Rights Campaign Foundation. "Our ... colleagues, customers and suppliers bring to CVS Health," said ...
(Date:12/5/2016)... 2016  New research by the CVS Health ... the U.S. Department of Health and Human Services, ... Response (ASPR), published online today in JAMA ... encourage patients with chronic conditions to refill medications ... also affirms that public-private partnerships can facilitate timely ...
(Date:12/5/2016)... 5, 2016 For the third consecutive year, ... Human Rights Campaign Foundation,s (HRC) annual ... national benchmarking tool used to rate companies on policies ... employee equality. For the last 15 years, ... gauge their equality efforts, culture and business practices. The ...
Breaking Medicine Technology: