Navigation Links
World-first discovery could help treat life-threatening tumors
Date:4/16/2008

WA researchers investigating how blood vessel growth keeps cancers alive have made a world-first discovery that could boost the chances of successfully treating life-threatening tumours.

Western Australian Institute for Medical Research (WAIMR) Associate Professor Ruth Ganss and her team have found that a gene called RGS5 can reverse angiogenesis the growth of blood vessels inside the tumour.

The discovery is published in the most recent edition of Nature, one of the worlds most prestigious scientific journals.

Its the uncontrolled growth of blood vessels and the formation of abnormal blood vessels inside tumours that feed them, allowing them to grow and stopping the immune system from wiping out the tumour, said Associate Professor Ganss.

What weve shown is that RGS5 is a master gene in angiogenesis and that when it is removed, angiogenesis reverses and the blood vessels in tumours appear more normal.

Importantly, this normalisation changes the tumour environment in a way that improves immune cell entry, meaning tumours can be destroyed and improving survival rates in laboratory tests.

Reversing abnormal vessel growth represents a fresh approach to tackling angiogenesis, with most current research focusing on how to block or kill tumour-feeding blood vessels.

Weve long-suspected this research would deliver advances in knowledge about what impacts tumour growth and this publication recognises the innovation and importance of our work, said Associate Professor Ganss.

By understanding what is actually going on in the tumour itself, the ultimate hope is that well be able to work on making current therapeutic approaches even more successful and reducing side effects of them.

Associate Professor Ganss breakthrough comes after joining WAIMR from Heidelberg where she worked at the German Cancer Research Center. Last month, The Cancer Council Western Australia granted Associate Professor Ganss a Cancer Council Research Fellowship for continued work into tumour angiogenesis.

The majority of the discovery was funded by the National Health and Medical Research Council and part of the work was achieved using facilities at The University of WA based Centre for Microscopy, Characterisation and Analysis.

Earlier this month, a second paper by Associate Professor Ganss and her team was published in The Journal of Clinical Investigation which describes how tumours can be attacked by the immune system with fewer side-effects.

This discovery involves targeting tumours with inflammatory substances that change the environment, so immune cells can attack the tumour through blood vessels more effectively and lessen the amount of toxins going elsewhere in the body, Associate Professor Ganss said.

WAIMR Director Professor Peter Klinken praised Associate Professor Ganss team saying their work was serving to further put WA on the scientific world map.

This breakthrough is one of the most significant discoveries to come out of WAIMR. The potential for this new knowledge to positively impact the lives of cancer patients in the future is very exciting, he said.

The fact that this breakthrough has come during our 10-year anniversary celebrations is just fantastic.


'/>"/>

Contact: Sarah Hayward
sarah@capturemedia.com.au
61-893-889-280
Research Australia
Source:Eurekalert

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Stem cell research produces a key discovery for Fragile X Syndrome
4. Welch Foundation gives $1.6 million for drug discovery research
5. New discovery leaves blood-doping athletes scratching their heads
6. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
7. New discovery leaves blood-doping athletes scratching their heads
8. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
9. Discovery supports theory of Alzheimers disease as form of diabetes
10. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
11. New discovery may improve treatment of one of the worlds leading causes of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... The Karen Miller Agency, a ... in the greater Birmingham area, is joining the Chris Hammond Youth Foundation in ... the region. , The Chris Hammond Youth Foundation maintains athletic facilities in rural ...
(Date:7/21/2017)... ... July 21, 2017 , ... Fresh Wave® IAQ today announced ... odor-control solution for colleges and universities at the APPA 2017 Annual Conference ... cannabis and tobacco smoke odors without the use of harsh chemicals, Fresh Wave IAQ ...
(Date:7/21/2017)... ... , ... Hospital M&A activity slowed in the second quarter of 2017, according ... to 23 in the second quarter, up 15% from the 20 publicly announced acquisitions ... in the year-ago second quarter. Only four of the transactions disclosed a purchase price ...
(Date:7/21/2017)... ... 2017 , ... The Margarian Law Firm has filed a class action ... for allegedly containing no ginger. Dr. Pepper produces the “Canada Dry” brand of ginger ... alleges Canada Dry Ginger Ale claims on its bottle that it is made from ...
(Date:7/21/2017)... ... 21, 2017 , ... The Visiting Nurse Association of ... R. Bard Foundation, Inc. to support the music therapy program offered at ... the nonprofit home care agency. Using evidence-based methods, professionally trained and certified music ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... 13, 2017 It should come as no surprise ... is in the midst of a crippling opioid epidemic. According ... the number of overdose deaths from opiate-based medications has quadrupled, ... a million dead from 2001 to 2015". During this time, ... has similarly quadrupled, drawing a compelling link between prescription and ...
(Date:7/12/2017)... INDIANAPOLIS , July 12, 2017  Eli Lilly and ... settlement agreement with generic companies to resolve pending patent litigation ... Virginia regarding the Cialis ® ... expire on April 26, 2020. As part of the agreement, ... on September 27, 2018. "The unit dose patent ...
(Date:7/11/2017)... 11, 2017  Dr. Echenberg, founder of Echenberg Institute, is announcing a ... who suffer from painful intercourse and other painful pelvic pain conditions such ... to menopause. ... LLC ... Sarasota, Florida -based start-up company, VuVatech LLC, fills a void ...
Breaking Medicine Technology: