Navigation Links
World-first discovery could help treat life-threatening tumors
Date:4/16/2008

WA researchers investigating how blood vessel growth keeps cancers alive have made a world-first discovery that could boost the chances of successfully treating life-threatening tumours.

Western Australian Institute for Medical Research (WAIMR) Associate Professor Ruth Ganss and her team have found that a gene called RGS5 can reverse angiogenesis the growth of blood vessels inside the tumour.

The discovery is published in the most recent edition of Nature, one of the worlds most prestigious scientific journals.

Its the uncontrolled growth of blood vessels and the formation of abnormal blood vessels inside tumours that feed them, allowing them to grow and stopping the immune system from wiping out the tumour, said Associate Professor Ganss.

What weve shown is that RGS5 is a master gene in angiogenesis and that when it is removed, angiogenesis reverses and the blood vessels in tumours appear more normal.

Importantly, this normalisation changes the tumour environment in a way that improves immune cell entry, meaning tumours can be destroyed and improving survival rates in laboratory tests.

Reversing abnormal vessel growth represents a fresh approach to tackling angiogenesis, with most current research focusing on how to block or kill tumour-feeding blood vessels.

Weve long-suspected this research would deliver advances in knowledge about what impacts tumour growth and this publication recognises the innovation and importance of our work, said Associate Professor Ganss.

By understanding what is actually going on in the tumour itself, the ultimate hope is that well be able to work on making current therapeutic approaches even more successful and reducing side effects of them.

Associate Professor Ganss breakthrough comes after joining WAIMR from Heidelberg where she worked at the German Cancer Research Center. Last month, The Cancer Council Western Australia granted Associate Professor Ganss a Cancer Council Research Fellowship for continued work into tumour angiogenesis.

The majority of the discovery was funded by the National Health and Medical Research Council and part of the work was achieved using facilities at The University of WA based Centre for Microscopy, Characterisation and Analysis.

Earlier this month, a second paper by Associate Professor Ganss and her team was published in The Journal of Clinical Investigation which describes how tumours can be attacked by the immune system with fewer side-effects.

This discovery involves targeting tumours with inflammatory substances that change the environment, so immune cells can attack the tumour through blood vessels more effectively and lessen the amount of toxins going elsewhere in the body, Associate Professor Ganss said.

WAIMR Director Professor Peter Klinken praised Associate Professor Ganss team saying their work was serving to further put WA on the scientific world map.

This breakthrough is one of the most significant discoveries to come out of WAIMR. The potential for this new knowledge to positively impact the lives of cancer patients in the future is very exciting, he said.

The fact that this breakthrough has come during our 10-year anniversary celebrations is just fantastic.


'/>"/>

Contact: Sarah Hayward
sarah@capturemedia.com.au
61-893-889-280
Research Australia
Source:Eurekalert

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Stem cell research produces a key discovery for Fragile X Syndrome
4. Welch Foundation gives $1.6 million for drug discovery research
5. New discovery leaves blood-doping athletes scratching their heads
6. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
7. New discovery leaves blood-doping athletes scratching their heads
8. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
9. Discovery supports theory of Alzheimers disease as form of diabetes
10. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
11. New discovery may improve treatment of one of the worlds leading causes of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... ... March 27, 2017 , ... Drs. Justin Kolnick, Kara Diamond, Randall Barton, Keith ... about the key role this treatment plays in protecting oral health, along with the ... serve those who need a root canal in White Plains, NY or their second ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... announced it will co-exhibit with technology partners LG Business Solutions at ATARC ... Metro Center in Washington D.C., will provide education and examination into the mobility ...
(Date:3/27/2017)... ... 27, 2017 , ... The Case Management Society of America (CMSA) will install ... CMSA’s membership has elected their upcoming President-Elect, Secretary, Treasurer and two Directors to ... new VA Advisory position has also been added to the BOD, per an appointment ...
(Date:3/27/2017)... ... 2017 , ... Advantexe Learning Solutions , a global ... new research study, The Business Readiness Report. The report explores the correlation between ... actual success of achieving individual and company goals. , There are many ...
(Date:3/27/2017)... CA (PRWEB) , ... March 27, 2017 , ... Janet Schloz is still in shock ... the best days I’ve had in a long time,” she said. , She thinks the ... of money that I never thought I would have to help my students.” , The ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017 New England ... recipient of an award including funding and in-kind service ... draw technology.  "Making blood draws less ... making their whole hospital experience better.  We,re looking forward ... technology can help improve care for the kids we ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global Wound ... report to their offering. ... The global wound care market was worth $24,482.9 million in 2015 and ... Among the various wound care products type, the advanced wound ... 2015. Among the various applications, surgical wound segment held the largest share ...
(Date:3/24/2017)... DUBLIN , Mar. 24, 2017 Research and ... Strategic Business Report" report to their offering. ... This report analyzes the worldwide markets for Dental ... US, Canada , Japan , ... America , and Rest of World. Annual estimates ...
Breaking Medicine Technology: