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World Leaders in Alzheimer’s Innovation to Discuss Progress, Collaboration at DIA Annual Meeting
Date:6/17/2013

.href)">Advancing Alzheimer’s Innovation: A Call to Action.

Tanzi, leader of the Whole Genome Sequencing Project, aims to propel research to identify the genetic risk for Alzheimer’s disease—a vital step in discovering a therapy.

“We are taking advantage of cutting-edge technology to discover exactly how our genes determine susceptibility to Alzheimer’s disease,” Tanzi said. “This panel will discuss how this key knowledge will pioneer novel drug discovery efforts and pave the future of Alzheimer’s research.”

Sperling is the principal investigator for the first-ever clinical trial aimed at older people who are at genetic risk of developing Alzheimer’s, but who have yet to show symptoms. Sperling will discuss the new era of prevention trials and the importance of studying the role gender may play in developing the disease. The three-year-long clinical trial, launching in November, will be made up of 1,000 older individuals and is funded jointly by the National Institutes of Health and Eli Lilly.

“It is critical to understand the interaction of risk factors and biological markers of disease pathology as we move forward with the trial,” Sperling said.

Adding to the discussion about innovative approaches to treating Alzheimer’s, Dr. Nicholas Kozauer, clinical lead for the Food and Drug Administration’s Division of Neurology Products, will address the need for a regulatory framework for pre-dementia clinical trials. In March, Kozauer published a compelling piece in the New England Journal of Medicine on the need for innovative approaches in trial design and selection as the drug-development community turns its sights on the early stages of the disease.

The session is chaired by Meryl Comer, president of the Geoffrey Beene Foundation Alzheimer’s Initiative, which just launched a $100,00
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