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World AIDS Vaccine Day 2008
Date:5/16/2008

rus in check indefinitely. Scientists are now actively studying the immune responses of these unique individuals to identify clues that could help in the design of an effective AIDS vaccine.

Second, some HIV-infected individuals develop antibodies that are capable of neutralizing a broad range of HIV strains. To date, scientists have identified and mapped the structure of several of these antibodies and are actively trying to design immunogens that can stimulate the production of these antibodies in humans.

Finally, non-human primates immunized with a live, but weakened form of the simian equivalent of HIV are protected from infection. For safety reasons, we cannot immunize humans with weakened HIV, but scientists are actively studying the immune responses of these animals to better understand what it is that protects them from infection and to replicate these responses in the next generation of AIDS vaccine candidates.

Developing an AIDS vaccine is pioneering science. Scientists are hard at work on fresh new approaches to AIDS vaccines. Many of the AIDS vaccine candidates in the current pipeline focus on one arm of the immune system, aiming to stimulate T-cell immunity. It is likely that a fully preventive vaccine will need to stimulate both T-cell and antibody immune responses: antibodies to prevent the initial infection and T-cell immunity to mop up any rogue cells that do become infected. AIDS vaccine researchers are focused on both of these approaches, designing new vectors to carry the vaccine inserts, including some that replicate in the mucosal surfaces where HIV often enters the body. Experts are also collaborating worldwide to develop vaccine antigens that elicit broadly neutralizing antibodies and are even testing new technologies that could help to more effectively deliver vaccines. This past year alone, several organizations, including IAVI, have also created financing incentives to encourage biotechnology companies, which oft
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SOURCE International AIDS Vaccine Initiative
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