Navigation Links
Working-Memory Gene Linked to Schizophrenia
Date:3/31/2010

Communication breakdown within brain disrupts executive functioning, researchers note

WEDNESDAY, March 31 (HealthDay News) -- Schizophrenia may be caused by a genetic mutation that disrupts communication between the hippocampus and prefrontal cortex regions, areas of the brain involved in working memory, U.S. researchers report.

Previous research has shown that about 30 percent of people with a micro-deletion on chromosome 22 -- known as 22q11 -- will go on to develop schizophrenia.

"We know that this genetic deficit predisposes [people] to schizophrenia, and now we have identified a clear pathophysiological mechanism of how this deletion confers this risk for schizophrenia," study senior author Dr. Maria Karayiorgou, a professor of psychiatry at Columbia University Medical Center, said in a news release.

She discovered the link between the 22q11 deletion and schizophrenia in 1995.

In this new study, Karayiorgou and colleagues found that mice with the 22q11 deletion performed much worse on tests of working memory than normal mice. Working memory is a key element of executive functioning.

Delusions and hallucinations are the most widely known symptoms of schizophrenia, but it's the impact on cognitive abilities, such as working memory, that most affects how a person with schizophrenia is able to function in society, the researchers explained.

In healthy mice, the hippocampus sends spatial information to the prefrontal cortex. In mice with the 22q11 deletion, there is a breakdown in this connection and communication between the two brain regions is either weakened or fails completely.

The study is published in the March 31 online edition of the journal Nature.

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: Columbia University, news release, March 31, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Obesity, Alcohol Among Factors Linked to Womens Gout Risk
2. Shift Work Linked to Irritable Bowel Syndrome
3. Heavy Daily Drinking Linked to Worse Health
4. Chronic Disease Linked to Less Internet Usage
5. Memory decline linked to an inability to ignore distractions
6. Researchers Identify 2 Genes Linked to Fatty Liver Disease
7. Gene Linked to Lung Cancer Risk in Non-Smokers
8. Gene is linked to lung cancer development in never-smokers
9. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
10. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
11. Cellular pathway could provide evidence of how cancer and obesity are linked
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... February 13, 2016 , ... The producers of Enterprises ... businesses. , The increasingly modern world of instantaneous consumption proves very convenient for ... sources such as oil and coal, which pollutes our air, water, and soil. It ...
(Date:2/13/2016)... ... February 13, 2016 , ... In the early or “honeymoon” stage of ... perfection, go out of their way to be romantic, and may exaggerate a strength ... at any online dating profile. , A recent study from Queendom.com , ...
(Date:2/12/2016)... ... 12, 2016 , ... The law firm of Morrow, Morrow, Ryan & Bassett ... of these scholarships is to encourage applicants to pursue a degree in their field ... two parishes. , “We have available jobs in St. Landry and Evangeline Parishes ...
(Date:2/12/2016)... VA (PRWEB) , ... February 12, 2016 , ... ... Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, http://www.fdanews.com/fixeddosecombination ... in the life cycle of pharmaceutical products, garnering increased attention from all stakeholders ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a technology ... for the ISE Southeast Awards 2016. Finalists and winners of the ISE® Awards ... Executive Forum and Awards Gala on March 15, 2016 at the Westin Peachtree ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Ky. , Feb. 12, 2016 /PRNewswire/ ... has completed a $47.1 million Series D ... Cormorant Asset Management, Hillhouse Capital Group and ... Morningside Venture Investments, AJU IB Investment, and ... be used to further advance clinical trials ...
(Date:2/11/2016)... 11, 2016 The primary goal of this ... patterns on the usage of liquid biopsy. Key information ... - Timeframe of liquid biopsy adoption amidst future ... Evs—by organization type - Sample inflow to conduct liquid ... stool, serum, and so on. - Correlation analysis of ...
(Date:2/11/2016)... , Feb. 11, 2016  Kindred Biosciences, Inc. (NASDAQ: ... and improving the lives of pets, today announced the ... the New Animal Drug Application (NADA) for Zimeta™ (dipyrone ... study (KB0120) of Zimeta for the control of pyrexia ... --> --> The ...
Breaking Medicine Technology: