Navigation Links
Working-Memory Gene Linked to Schizophrenia
Date:3/31/2010

Communication breakdown within brain disrupts executive functioning, researchers note

WEDNESDAY, March 31 (HealthDay News) -- Schizophrenia may be caused by a genetic mutation that disrupts communication between the hippocampus and prefrontal cortex regions, areas of the brain involved in working memory, U.S. researchers report.

Previous research has shown that about 30 percent of people with a micro-deletion on chromosome 22 -- known as 22q11 -- will go on to develop schizophrenia.

"We know that this genetic deficit predisposes [people] to schizophrenia, and now we have identified a clear pathophysiological mechanism of how this deletion confers this risk for schizophrenia," study senior author Dr. Maria Karayiorgou, a professor of psychiatry at Columbia University Medical Center, said in a news release.

She discovered the link between the 22q11 deletion and schizophrenia in 1995.

In this new study, Karayiorgou and colleagues found that mice with the 22q11 deletion performed much worse on tests of working memory than normal mice. Working memory is a key element of executive functioning.

Delusions and hallucinations are the most widely known symptoms of schizophrenia, but it's the impact on cognitive abilities, such as working memory, that most affects how a person with schizophrenia is able to function in society, the researchers explained.

In healthy mice, the hippocampus sends spatial information to the prefrontal cortex. In mice with the 22q11 deletion, there is a breakdown in this connection and communication between the two brain regions is either weakened or fails completely.

The study is published in the March 31 online edition of the journal Nature.

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: Columbia University, news release, March 31, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Obesity, Alcohol Among Factors Linked to Womens Gout Risk
2. Shift Work Linked to Irritable Bowel Syndrome
3. Heavy Daily Drinking Linked to Worse Health
4. Chronic Disease Linked to Less Internet Usage
5. Memory decline linked to an inability to ignore distractions
6. Researchers Identify 2 Genes Linked to Fatty Liver Disease
7. Gene Linked to Lung Cancer Risk in Non-Smokers
8. Gene is linked to lung cancer development in never-smokers
9. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
10. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
11. Cellular pathway could provide evidence of how cancer and obesity are linked
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Yisrayl Hawkins, at The House of Yahweh in ... fits into Bible Prophecy. Yisrayl says this generation, known as the Last Generation, started ... how the details line up exactly with Bible Prophecy – a protected way for ...
(Date:12/2/2016)... Philadelphia, PA (PRWEB) , ... December 02, 2016 ... ... healthcare and pharmaceutical organizations to build intelligent, connected applications, was named the best ... , The winner announcement was made today by the Software & ...
(Date:11/30/2016)... ... 30, 2016 , ... Northridge dentists, Dr. Assili ... for all patients. Understanding that budget can play a part in oral health ... perks, including discounts on many valuable dental treatments. Options for individuals, couples, and ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For Discovery, a ... opening of a new residential mental health treatment program in Chino Hills, California.  The ... as severe anxiety, depression, bi-polar disorder, and other related issues. , Center For ...
(Date:11/30/2016)... Arizona (PRWEB) , ... November 30, 2016 , ... ... Associates, has expanded its orthopedic practice with the addition of new North Phoenix ... Honor Health John C. Lincoln North Mountain campus at 9327 North 3rd St, ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , December 2, 2016 Persistence ... pacemaker market in its upcoming report titled, "Global Market Study on ... Declining CAGR of -1.4% between 2016 and 2024". The global ... in 2015 and this is likely to decline to ... the global cardiac pacemaker market is anticipated to exhibit ...
(Date:12/2/2016)... 2016 According to the latest market ... on Automated Endoscope Reprocessors: Single Basin Automated Endoscope Reprocessors Product ... 2016 and 2024 " the global automated endoscope reprocessors market was valued at ... at a CAGR of 7.2% during an eight-year forecast period ... by 2024. ...
(Date:12/2/2016)... -- Quantum Radiology,s Mobile Breast Center (QR MBC) brings ... women at the workplace, thereby maximizing convenience and compliance.  ... Lines and SunTrust Bank, and community health groups to ... initiatives. "I think it,s a great service ... have a mammogram without taking a large amount of ...
Breaking Medicine Technology: