Navigation Links
Working-Memory Gene Linked to Schizophrenia
Date:3/31/2010

Communication breakdown within brain disrupts executive functioning, researchers note

WEDNESDAY, March 31 (HealthDay News) -- Schizophrenia may be caused by a genetic mutation that disrupts communication between the hippocampus and prefrontal cortex regions, areas of the brain involved in working memory, U.S. researchers report.

Previous research has shown that about 30 percent of people with a micro-deletion on chromosome 22 -- known as 22q11 -- will go on to develop schizophrenia.

"We know that this genetic deficit predisposes [people] to schizophrenia, and now we have identified a clear pathophysiological mechanism of how this deletion confers this risk for schizophrenia," study senior author Dr. Maria Karayiorgou, a professor of psychiatry at Columbia University Medical Center, said in a news release.

She discovered the link between the 22q11 deletion and schizophrenia in 1995.

In this new study, Karayiorgou and colleagues found that mice with the 22q11 deletion performed much worse on tests of working memory than normal mice. Working memory is a key element of executive functioning.

Delusions and hallucinations are the most widely known symptoms of schizophrenia, but it's the impact on cognitive abilities, such as working memory, that most affects how a person with schizophrenia is able to function in society, the researchers explained.

In healthy mice, the hippocampus sends spatial information to the prefrontal cortex. In mice with the 22q11 deletion, there is a breakdown in this connection and communication between the two brain regions is either weakened or fails completely.

The study is published in the March 31 online edition of the journal Nature.

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: Columbia University, news release, March 31, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Obesity, Alcohol Among Factors Linked to Womens Gout Risk
2. Shift Work Linked to Irritable Bowel Syndrome
3. Heavy Daily Drinking Linked to Worse Health
4. Chronic Disease Linked to Less Internet Usage
5. Memory decline linked to an inability to ignore distractions
6. Researchers Identify 2 Genes Linked to Fatty Liver Disease
7. Gene Linked to Lung Cancer Risk in Non-Smokers
8. Gene is linked to lung cancer development in never-smokers
9. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
10. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
11. Cellular pathway could provide evidence of how cancer and obesity are linked
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the ... today its plans to open a flagship location in Covington, LA at 401 N. ... To Go store next to Office Depot in the Holiday Square shopping center. Its ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... ... , ... On Saturday, October 21, the Health & Wellness Center at Florida ... money for the American Heart Association Heart Walk. Teams of up to 10 people ... keep their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. on ...
(Date:10/12/2017)... ... October 12, 2017 , ... In ... taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, ... overseas retirement havens have extremely low property-tax rates, which contributes to the relatively ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/23/2017)... 2017 Janssen Biotech, Inc. (Janssen) announced today ... the U.S. Food and Drug Administration (FDA) for the ... the treatment of moderately to severely active rheumatoid arthritis ... are needed to further evaluate the safety of sirukumab ... "We are ...
Breaking Medicine Technology: