Navigation Links
Working-Memory Gene Linked to Schizophrenia
Date:3/31/2010

Communication breakdown within brain disrupts executive functioning, researchers note

WEDNESDAY, March 31 (HealthDay News) -- Schizophrenia may be caused by a genetic mutation that disrupts communication between the hippocampus and prefrontal cortex regions, areas of the brain involved in working memory, U.S. researchers report.

Previous research has shown that about 30 percent of people with a micro-deletion on chromosome 22 -- known as 22q11 -- will go on to develop schizophrenia.

"We know that this genetic deficit predisposes [people] to schizophrenia, and now we have identified a clear pathophysiological mechanism of how this deletion confers this risk for schizophrenia," study senior author Dr. Maria Karayiorgou, a professor of psychiatry at Columbia University Medical Center, said in a news release.

She discovered the link between the 22q11 deletion and schizophrenia in 1995.

In this new study, Karayiorgou and colleagues found that mice with the 22q11 deletion performed much worse on tests of working memory than normal mice. Working memory is a key element of executive functioning.

Delusions and hallucinations are the most widely known symptoms of schizophrenia, but it's the impact on cognitive abilities, such as working memory, that most affects how a person with schizophrenia is able to function in society, the researchers explained.

In healthy mice, the hippocampus sends spatial information to the prefrontal cortex. In mice with the 22q11 deletion, there is a breakdown in this connection and communication between the two brain regions is either weakened or fails completely.

The study is published in the March 31 online edition of the journal Nature.

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: Columbia University, news release, March 31, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Obesity, Alcohol Among Factors Linked to Womens Gout Risk
2. Shift Work Linked to Irritable Bowel Syndrome
3. Heavy Daily Drinking Linked to Worse Health
4. Chronic Disease Linked to Less Internet Usage
5. Memory decline linked to an inability to ignore distractions
6. Researchers Identify 2 Genes Linked to Fatty Liver Disease
7. Gene Linked to Lung Cancer Risk in Non-Smokers
8. Gene is linked to lung cancer development in never-smokers
9. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
10. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
11. Cellular pathway could provide evidence of how cancer and obesity are linked
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... , ... SuperCloset is proud to officially launch our “Helping Veterans Grow ... and obstacles veterans’ need to overcome in order to face their life changes upon ... veteran(s) with a donated SuperCloset product based on the needs and ability of helping ...
(Date:5/27/2016)... ... ... More than a third of American adults are considered obese, says the ... increased attention in recent years, as an article published May 18th on ... people are familiar with the basic requirements of maintaining a healthy diet and exercise ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent of acute ... for a sustainable product to aid in the rehabilitation process has steadily increased. Ekso ... of individuals with hemiplegia due to stroke. , Ekso Bionics has now received clearance ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, ... ... health care world, this installment is bolstered by inspiring human interest stories, courtesy ... to the developing trends and tech within the industry, from leading advocates and ...
(Date:5/26/2016)... ... ... There are many ways to cook a hot dog, but new research commissioned ... dogs straight off the grill. Of the 90 percent of Americans who say they ... hot dog, far outpacing other cooking methods such as steaming (12 percent), microwaving (9 ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... Amarantus BioScience Holdings, Inc. (OTCQX: AMBS), ... and Orphan Diseases, today announced that President & CEO Gerald ... SeeThru Equity MicroCap Conference   Where: ... , NY When: Tuesday, May 31 st , ... Where: Grand Hyatt Hotel, 109 East 42 nd St, ...
(Date:5/26/2016)... May 26, 2016   Change Healthcare ... analytics, network solutions and technology-enabled services designed ... entered into a strategic channel partnership with ... software solutions and revenue cycle management services ... and rehabilitation clinics to optimize revenue, operational ...
(Date:5/25/2016)... , Germany and GERMANTOWN, ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... licensing and co-development agreement with Therawis Diagnostics GmbH to develop ... be to develop and market PITX2 as a marker to ... high-risk breast cancer patients. "We are pleased to ...
Breaking Medicine Technology: