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Work with fungus uncovering keys to DNA methylation
Date:12/15/2008

ang Fischle, a biochemist at the Max-Planck Institute for Biophysical Chemistry, praises the findings of Selker and Adhvaryu. He writes that there appears to be extensive "crosstalk" involved in the chemical modifications that occur on histones to influence other enzymes that interact with chromatin "Adhvaryu and Selker provide novel insights into an intricate regulatory network involving histone phosphorylation, histone methylation and DNA methylation," he noted.

"DNA methylation seems to be a luxury item in Neurospora, which means we can manipulate it as we wish, making mutants that don't do it and thereby identify important players," Selker said. "We are identifying how DNA methylation is controlled and what it does in this organism. Our assumption is that a lot of what we find in Neurospora will be applicable to other systems."

In this case, Selker said, Keyur demonstrated very nicely, in a couple different ways, that protein phosphatase PP1 is required for normal DNA methylation. "DNA methylation is involved in a silencing of invasive DNA as well as a variety of normal genes, including those on the inactive X chromosome, those subjected to imprinting, and well as tumor suppressor genes," he said, adding that methylation of the latter class of genes can lead to cancer.


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Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert  

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Work with fungus uncovering keys to DNA methylation
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