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Work in cells, animals, patients reveals toxin's role in asthma
Date:12/14/2011

Peter Dube, Ph.D., associate professor of microbiology and immunology, leads a separate group that is studying mouse models' responses to the CARDS toxin. "We are modeling different aspects of human disease and have a very relevant model that recapitulates what is seen in allergic asthma in humans," Dr. Dube said.

P. John Hart, Ph.D., professor of biochemistry, is experienced in X-ray crystallography, a technique to determine the three-dimensional structure of proteins. "The CARDS toxin from M. pneumoniae is an incredibly interesting molecular machine," he said. "The structure-based approaches coming from my laboratory, together with the cell-based, animal-based and patient-based approaches coming from laboratories of our collaborators, are working synergistically to provide an understanding of its mechanism of action and its role in airway disease."

Dr. Baseman summed it up: "This is five years later, and it's become even more of an intriguing and exciting story."


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Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

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