Navigation Links
Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile
Date:7/9/2014

PROVIDENCE, R.I. Researchers have found that fecal transplantation is effective and safe for treating C. difficile in immunocompromised patients. This is the result of a study led by Colleen Kelly, M.D., a gastroenterologist in the Center for Women's Gastrointestinal Medicine at The Women's Medicine Collaborative. The study and its findings have been published online in advance of print in the American Journal of Gastroenterology.

Clostridium difficile, or C. diff, has increased to epidemic proportions over the past decade. It is an infection that is often difficult to treat and leaves sufferers with frequent diarrhea, abdominal pain, nausea, and fever and can lead to dehydration, loss of appetite and weight loss. Patients who are immunocompromised, or considered high-risk, are more susceptible, and historically, there has been concern that these patients may be at increased risk of infections related to fecal transplant. However, this study found fecal transplant to be effective for the treatment of C. diff infection among immunocompromised patients.

"To date, no study has consistently investigated the safety and efficacy of fecal transplant in immunocompromised patients," Kelly said. "These patients have previously been excluded from clinical trials of fecal transplant because of the fear that they are at high risk of infection related to the procedure. As a result, doctors might be cautious about treating patients with compromised immune systems using fecal transplant."

Increased lengths of stay in hospitals and extended-care facilities, in addition to broad-spectrum antibiotics, increase C. diff infection risk among immunocompromised patients. The infection is responsible for 15 to 25 percent of hospital acquired antibiotic-associated diarrhea and has increased rapidly over the past 10 years to an incidence of 10.4 cases per 1,000 patient admissions. Recurrence is common and occurs in up to 20 percent of patients after initial treatment for C. diff infection.

Kelly and her colleagues have treated a number of immunocompromised patients with fecal transplant, and sought to use this collective experience to describe C. diff infection cure rates among immunocompromised individuals, as well as adverse events, such as death or hospitalization, experienced by immunocompromised patients after fecal transplant. Researchers reviewed the records of 75 adult and five pediatric patients with fecal transplant for C. diff infection. Reasons for being immunocompromised included: HIV/AIDS, solid organ transplant, an oncologic condition, immunosuppressive therapy for inflammatory bowel disease, and other medical conditions/medications, such as cirrhosis and end stage kidney disease.

Analysis found an overall cure rate of 89 percent. While not directly related to fecal transplant, 12 patients had serious adverse effects (such as hospitalization) within 12 weeks of the procedure. Among these were two deaths one resulted from aspiration during sedation for the colonoscopy used to administer fecal transplant; the other was unrelated to fecal transplant. Some patients with inflammatory bowel disease experienced disease flares after transplant, but no patient suffered infections related to fecal transplant.

"Our study demonstrated the effective use of fecal transplant for C. diff infection in immunocompromised patients with few undesired harmful effects, and, importantly, there were no related infectious complications in these high-risk patients," Kelly said. "The key message here is that physicians do not need to be afraid to use fecal transplant in patients who are immunocompromised. Our findings show fecal transplant is both safe and effective in immunocompromised patients."


'/>"/>

Contact: Elena Falcone-Relvas
efalconerelvas@lifespan.org
401-793-7484
Lifespan
Source:Eurekalert

Related medicine news :

1. Telemedicine for patients with chronic liver diseases
2. UCLA addresses lost in translation issues in Chinese medicine
3. Northwestern Medicine cardiologist is American Heart Association Physician of the Year
4. NIH awards $10.7 million to University of Maryland School of Medicine
5. Benefits of PTSD treatment going unmeasured, says Institute of Medicine Report
6. U of MD researchers receive NIH grant to study personalized medicine for genetic diabetes
7. Register now for the worlds premier international congress in cardiovascular medicine
8. New from Garland Science -- now available: Genetics and Genomics in Medicine
9. Penn Medicine at the International Congress of Parkinsons Disease and Movement Disorders
10. Barry A. Siegel, M.D., receives 2014 Benedict Cassen Prize for Research in Nuclear Medicine
11. Opioid overdose prevention programs may reduce deaths, reports Journal of Addiction Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... Overland Park, KS (PRWEB) , ... January 18, ... ... family managed firm offering asset protection and financial planning services to families and ... for a charity event aimed at supporting children with developmental disabilities. , The ...
(Date:1/18/2017)... Alexandria, VA (PRWEB) , ... January 18, 2017 , ... ... services in family, cosmetic and implants dentistry. His modern dental practice has two convenient ... Qureshi as a 2017 Top Rated Dentist for the Alexandria area. This ...
(Date:1/18/2017)... ... January 18, 2017 , ... Michael J. ... website for its Center for Biosimilars, announced Michael J. Hennessy Associates, Inc. President ... the field of biosimilars through thought leader interaction in, live video and interactive ...
(Date:1/18/2017)... ... January 18, 2017 , ... Rollerblade®, ... Brake Technology (ABT), an innovative braking system that allows skaters of all levels ... one of the biggest concerns of beginner and intermediate skaters – learning how ...
(Date:1/18/2017)... ... 18, 2017 , ... Floundering on New Year’s resolutions? Need an excuse to ... a reset. The U.S. Apple Association agrees and recommends starting each day with ... contribute to heart disease. , The U.S. Apple Association – which represents apple growers ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... , Jan. 18, 2017  Adaptive Sound Technologies, Inc. ... a new partnership with Hyatt Place Nashville/Downtown to deliver ... ASTI LectroFan sleep therapy machines in over two hundred ... the most important parts of having a great stay ... manager of Hyatt Place Nashville/Downtown. "We,re pleased to be ...
(Date:1/18/2017)... Jan. 18, 2017  Kratom leaves, from a ... are often used to prepare tea-like beverages and ... million Americans annually to increase alertness, enhance well-being ... for minor aches and pains. PinneyAssociates, review of ... to assist FDA and DEA in determining the ...
(Date:1/18/2017)... -- Research and Markets has announced the addition of ... report to their offering. ... The global CINV drugs market to grow at a ... Thoracic Surgery Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. To ...
Breaking Medicine Technology: