Navigation Links
Women's Chromosomes May Affect Blood Pressure

The effect might be strongest after menopause, mouse study suggests

MONDAY, March 15 (HealthDay News) -- Scientists have believed that testosterone and estrogen play a major role in regulating blood pressure, but a new study in mice suggests that female sex chromosomes could also be key, at least after menopause begins.

In the study, researchers genetically engineered male mice to have female chromosomes (XX) and females to have male chromosomes (YY). They found that the chromosomes affected the rodents' blood pressure on their own.

"XX mice have a greater magnitude of hypertension than XY mice regardless of whether they are male or female," lead investigator Kathryn Sandberg, director of the Georgetown University Medical Center for the Study of Sex Differences in Health, Aging and Disease, said in a news release from Georgetown.

"Up until now, it has been impossible to separate the influence of sex chromosomes from the effects of sex hormones, and in this paper, we have shown for the first time that sex chromosomes are impacting blood pressure -- independent of sex hormones," she said. "That is not to say sex hormones don't matter in blood pressure regulation, because they do, but we now know they aren't the only players."

Why does this matter?

Because "there is a real jump in blood pressure and incidence of hypertension in menopausal women, and while the condition is treatable, blood pressure in many of these women is not fully under control, making them far more susceptible to cardiovascular and kidney disease and stroke," Sandberg said. "Therefore, it would be wonderful to have specific therapies that target the root cause of this hypertension."

The study appears online March 15 in the journal Hypertension.

More information:

There's more on hypertension at the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCE: Georgetown University Medical Center, press release, March 15, 2010.

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Womenshealthchannel Enhancements Support Pregnant Teens
2. Infectious Virus Hides In Human Chromosomes During Latency And Can Be Passed From Parents To Their Children
3. Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes
4. Research shines spotlight on a key player in the dance of chromosomes
5. Herceptin helps women with multiple chromosomes containing HER2 gene, study finds
6. Grant Supports Study of Abnormal Ring-Shaped Chromosomes
7. Insurance status of gunshot trauma patients affects mortality outcomes
8. Research: How you think about your age may affect how you age
9. Testosterone deficiency affects male cancer survivors quality of life
10. How does religion affect psychiatric treatment?
11. Chemical tags likely to affect metabolism, cancer development
Post Your Comments:
(Date:11/27/2015)... Raleigh, NC (PRWEB) , ... November 27, 2015 , ... ... most effective ways to treat it. Surviving Mesothelioma has just posted the findings ... Researchers at University Hospital Zurich analyzed the cases of 136 mesothelioma patients who were ...
(Date:11/27/2015)... ... November 27, 2015 , ... The print component ... Today in Atlanta, Dallas, New York, Minneapolis, South Florida, with a circulation of ... distributed nationally, through a vast social media strategy and across a network of ...
(Date:11/27/2015)... ... November 27, 2015 , ... Intellitec Solutions announced ... User Group (MSDSLUG). Recognized as Microsoft’s official group for end users of Dynamics ... software users, partners, industry experts and representatives. Intellitec Solutions’ membership status demonstrates their ...
(Date:11/27/2015)... ... November 27, 2015 , ... CBD College is proud to ... Programs (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography program. CBD College is honored ... one of twelve colleges and universities in the state of California make the cut. ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft Inc., ... the incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite 5.10 ... brings Q-Suite 5.10 up-to-date with a version of Asterisk that will receive not ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... -- Research and Markets ( ) has announced the ... to 2019 - Rise in Cardiac Disorders and Growing Awareness ... their offering. Boston scientific ... scientific and others. --> The market is ... Boston scientific and others. ...
(Date:11/26/2015)... 26, 2015 ... "2016 Future Horizons and Growth Strategies ... Market: Supplier Shares, Country Segment Forecasts, Competitive ... offering. --> ) has ... Future Horizons and Growth Strategies in the ...
(Date:11/26/2015)... , November 26, 2015 ... "Self Administration of High Viscosity Drugs" ... ) has announced the addition of the ... to their offering. --> Research and ... of the "Self Administration of High Viscosity ...
Breaking Medicine Technology: