Navigation Links
Women working shifts are at greater risk of miscarriage, menstrual disruption and subfertility
Date:7/9/2013

London, 9 July 2013: Shift work, which encourages sleep deprivation and patterns of activity outside the circadian rhythm, has been associated with a greater risk of ill health and loss of well-being in some (but not all) studies.(1) However, little is known about the effects of shift work on reproductive health and fertility.

Now, a study reported today at the annual meeting of ESHRE, by Dr Linden Stocker from the University of Southampton, UK, indicates that working shift patterns is associated with an increased risk of menstrual disruption and subfertility.

The study is a meta-analysis of all studies on the subject published between 1969 and January 2013. It compares the impact of non-standard working schedules (including night-shift work and mixed-shifts) with that in women not working shifts. The end-points were early reproductive outcome parameters, including menstrual dysregulation, female fertility and miscarriage rates.

The study, which included data on 119,345 women, found that those working shifts (alternating shifts, evenings and nights) had a 33% higher rate of menstrual disruption than those working regular hours (odds ratio 1.22, statistically significant) and an 80% increased rate of subfertility (OR 1.80, statistically significant).(2)

Women who worked only nights did not have a statistically increased risk of menstrual disruption or difficulty conceiving, but they did have an increased rate of miscarriage (OR 1.29), although this increased risk of miscarriage was not observed in women who worked nights as part of a shift pattern.

The investigators describe their findings as "novel", but in keeping with other studies (which found adverse effects in later pregnancy). "If replicated," they said, " our findings have implications for women attempting to become pregnant, as well as for their employers".

On the implications of the study Dr Stocker said: "Whilst we have demonstrated an association between shift work and negative early reproductive outcomes, we have not proven causation. In humans, the long-term effects of altering circadian rhythms are inherently difficult to study. As a proxy measure, the sleep disruption demonstrated by the shift workers in our study creates short- and long-term biological disturbances. Shift workers adopt poor sleep hygiene, suffer sleep deprivation and develop activity levels that are out-of-sync with their body clock.

"However, if our results are confirmed by other studies, there may be implications for shift workers and their reproductive plans. More friendly shift patterns with less impact on circadian rhythm could be adopted where practical - although the optimal shift pattern required to maximise reproductive potential is yet to be established."

In noting that only some reproductive outcomes were affected by shift work, Dr Stocker reported that the underlying biological disturbances involved in reproductive difficulties "are complex and not the same across all the disease processes". "Indeed," she said, "it is probable that completely different causes underlie menstrual dysfunction, miscarriage and subfertility.

This may explain why the effects of different types of shift work are seen in some groups of women, but not others."

She added that one possible explanation for the overall findings is that the disruption of circadian rhythm can influence the biological function of "clock genes", which have been shown to be associated with changes in biological functions.


'/>"/>

Contact: Christine Bauquis
christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

Related medicine news :

1. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
2. 62 percent of men and 37 percent of women over the age of 65 are sexually active
3. Obese White Women Shying Away From Colon Cancer Screening
4. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
5. Timing pregnancy an important health concern for women
6. White Women Make Up Bulk of Assisted-Living Residents
7. Stress contributes to cognitive declines in women with breast cancer, researcher says
8. Women Less Apt Than Men to Get Recommended Daily Exercise
9. Overweight Pregnant Women at Higher Risk for Complications
10. Women With Older Partners More Often Admitted to Nursing Homes
11. Research shows efficacy of treatment model developed at Women & Infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... , ... October 12, 2017 , ... IsoComforter, Inc. ( ... announced today the introduction of an innovative new design of the shoulder pad. ... you get maximum comfort while controlling your pain while using cold therapy. By utilizing ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s ... the 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
(Date:9/22/2017)... 2017  As the latest Obamacare repeal effort moves ... (R-LA) and Lindsey Graham (R-SC) medical ... device industry is in an odd place.  The industry ... excise tax on medical device sales passed along with ... patients, increased visits and hospital customers with the funding ...
(Date:9/18/2017)... 2017 EpiVax, Inc. ("EpiVax") a ... immune engineering, today announced a new NIH-funded ... ... and presents a challenge for traditional flu ... be effective. Using state-of-the-art bioinformatics and molecular modeling methods, ...
Breaking Medicine Technology: