Navigation Links
Women who inherit BRCA gene mutations develop cancer earlier than their ancestors
Date:9/11/2011

A new analysis has found that women who develop certain hereditary cancers develop them at earlier ages than women in the previous generation. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the results point to the importance of tracking younger ages of cancer diagnosis to determine when to provide counseling, screening, and treatment services.

Women who have mutations in the BRCA genes have a high risk of developing breast and ovarian cancers at young ages. Mutations in these genes are often inherited, so multiple family members may be diagnosed with these cancers at young ages. Researchers have wondered: if a woman develops BRCA-related cancer at a certain age, will female relatives in the next generation develop it even earlier?

To investigate, Jennifer Litton, MD, of the University of Texas MD Anderson Cancer Center in Houston, and her colleagues looked at trends in the age of cancer diagnosis between generations in families with a history of BRCA-related cancer. Of 132 women in the study who had breast cancer and BRCA gene mutations, 106 had a family member in the previous generation who was diagnosed with a BRCA-related cancer (either breast or ovarian cancer).

When evaluating age differences between generations in each family, the researchers found that the average age of cancer diagnosis in the second generation was 42 years, compared with 48 years in the first generation. A separate more inclusive analysis of the entire study group revealed that the expected age-of-onset of cancer went down by 7.9 years from the first generation to the second.

The results suggest that women who inherit BRCA gene mutations develop cancer at younger ages than women in the previous generation.

Guidelines by the National Comprehensive Cancer Network suggest initiating screening for hereditary breast cancer at age 25 years or five to ten years earlier than the age of earliest diagnosis in a family. "Our research tells us that we need to continue to initiate screenings at least ten years prior to the earliest cancer diagnosis," said Dr. Litton. "Also, because we do not have the BRCA mutation status of affected individuals from previous generations, when testing may not have been available yet, it is vital that we continue to collect family information," she added. Monitoring for shifts in the age of cancer diagnosis in future generations will help caregivers and patients decide when to consider counseling, screening, and treatments.


'/>"/>

Contact: Jennifer Beal
healthnews@wiley.com
44-012-437-70633
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. For Women, Moderate Midlife Drinking Linked to Healthier Old Age
2. Obesity and large waist size linked to higher risk of death in African-American women
3. Extra Pounds a Deadly Risk Factor for Black Women: Study
4. Young women with early breast cancer have similar survival with breast conservation, mastectomy
5. Aging, Not Menopause, Raises Womens Heart Risks, Study Finds
6. Sexist Men, Women May Be a Good Fit: Study
7. Being Heavier May Mean Fewer Hot Flashes for Women Over 60
8. Smoking Harder on Womens Arteries Than Mens, Scans Show
9. Women Married Before Age 18 at Higher Risk of Mental Woes: Study
10. For Women, Active Sex Life May Mean Better Aging
11. Faster Way to Treat Partners of Women With STDs Urged: Experts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... DUBLIN , June 27, 2016 Jazz ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... proposed acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... 11:59 p.m. (Eastern Daylight Time). As previously ... entered into a definitive merger agreement under which Jazz ...
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
Breaking Medicine Technology: