Navigation Links
Women who inherit BRCA gene mutations develop cancer earlier than their ancestors
Date:9/11/2011

A new analysis has found that women who develop certain hereditary cancers develop them at earlier ages than women in the previous generation. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the results point to the importance of tracking younger ages of cancer diagnosis to determine when to provide counseling, screening, and treatment services.

Women who have mutations in the BRCA genes have a high risk of developing breast and ovarian cancers at young ages. Mutations in these genes are often inherited, so multiple family members may be diagnosed with these cancers at young ages. Researchers have wondered: if a woman develops BRCA-related cancer at a certain age, will female relatives in the next generation develop it even earlier?

To investigate, Jennifer Litton, MD, of the University of Texas MD Anderson Cancer Center in Houston, and her colleagues looked at trends in the age of cancer diagnosis between generations in families with a history of BRCA-related cancer. Of 132 women in the study who had breast cancer and BRCA gene mutations, 106 had a family member in the previous generation who was diagnosed with a BRCA-related cancer (either breast or ovarian cancer).

When evaluating age differences between generations in each family, the researchers found that the average age of cancer diagnosis in the second generation was 42 years, compared with 48 years in the first generation. A separate more inclusive analysis of the entire study group revealed that the expected age-of-onset of cancer went down by 7.9 years from the first generation to the second.

The results suggest that women who inherit BRCA gene mutations develop cancer at younger ages than women in the previous generation.

Guidelines by the National Comprehensive Cancer Network suggest initiating screening for hereditary breast cancer at age 25 years or five to ten years earlier than the age of earliest diagnosis in a family. "Our research tells us that we need to continue to initiate screenings at least ten years prior to the earliest cancer diagnosis," said Dr. Litton. "Also, because we do not have the BRCA mutation status of affected individuals from previous generations, when testing may not have been available yet, it is vital that we continue to collect family information," she added. Monitoring for shifts in the age of cancer diagnosis in future generations will help caregivers and patients decide when to consider counseling, screening, and treatments.


'/>"/>

Contact: Jennifer Beal
healthnews@wiley.com
44-012-437-70633
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. For Women, Moderate Midlife Drinking Linked to Healthier Old Age
2. Obesity and large waist size linked to higher risk of death in African-American women
3. Extra Pounds a Deadly Risk Factor for Black Women: Study
4. Young women with early breast cancer have similar survival with breast conservation, mastectomy
5. Aging, Not Menopause, Raises Womens Heart Risks, Study Finds
6. Sexist Men, Women May Be a Good Fit: Study
7. Being Heavier May Mean Fewer Hot Flashes for Women Over 60
8. Smoking Harder on Womens Arteries Than Mens, Scans Show
9. Women Married Before Age 18 at Higher Risk of Mental Woes: Study
10. For Women, Active Sex Life May Mean Better Aging
11. Faster Way to Treat Partners of Women With STDs Urged: Experts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
Breaking Medicine Technology: