Navigation Links
Women who give birth to multiple babies after IVF are at higher risk of breast cancer
Date:7/9/2013

London -- Women who give birth to multiple babies following IVF treatment are at a higher risk of breast cancer than those giving birth to singletons or who remain childless. Dutch investigators from the Omega study group said the explanation may not be the multiple pregnancy per se but a maternal trait related to a higher implantation potential and to breast cancer itself.

Although the results were derived from a large nationwide cohort study, the investigators emphasise that the findings should next be replicated in further studies and that presently there is no reason for earlier breast cancer screening than is recommended for the general population.(1)

The study, presented today at the annual meeting of ESHRE by Dr Els Groeneveld from the VU University Medical Centre of Amsterdam, the Netherlands, analysed data from the Omega study, a large Dutch nationwide cohort of 19,861 women who received IVF or ICSI treatment between 1983 and 1995. Between 1997 and 1999 all patients were questioned (by questionnaire) about their treatment and its outcome. Those who completed the questionnaire (12,589 women) were cross-referred to the Netherlands Cancer Registry.

Cohort analysis showed that over a median 16.7 years of follow-up 1688 women in the study gave birth to multiples (13%), 6027 delivered singletons (48%), and 4874 remained childless (39%). Among these women there were 317 confirmed diagnoses of breast cancer, of whom 57 gave birth to multiples, 155 to singletons, and 105 remained childless. When these findings were analysed statistically, results showed that mothers of multiples had a (44%) higher breast cancer risk than the mothers of singletons (hazard ratio 1.44, statistically significant) when adjusted for year of IVF treatment, number of IVF cycles, height and age at first birth. Nulliparous women were at no increased risk of breast cancer.

Remarkably, only multiple pregnancies conceived after the complete implantation of all transferred embryos were associated with an increased breast cancer risk (HR 1.86), whereas multiple pregnancies conceived after incomplete implantation were not (HR 1.31, not statistically significant). This finding, says Dr Groeneveld, supports the hypothesis of a link between high embryo implantation potential and breast cancer risk.

She explained: "It has been generally assumed that increased levels of estrogen and progesterone in multiple pregnancies stimulate cellular proliferation in the breast, which increases accumulation of somatic mutations during cell division and leads to the development of breast cancer. Thus, breast cancer could be seen as a consequence of the multiple pregnancy itself. However, we also hypothesise that an additional maternal trait might be associated with an increased breast cancer risk in these women."

Such a trait could be maternal serum concentrations of vascular endothelial growth factor (VEGF), a known protein involved in breast cancer progression and which Dr Groeneveld's group in Amsterdam has recently found associated with improved embryo implantation potential.

"In our study women who developed a multiple pregnancy from all transferred embryos represent women with high embryo implantation potential, possibly through increased levels of VEGF," said Dr Groeneveld. "Future studies will reveal whether the significant association between improved embryo implantation potential and breast cancer risk shown in our study is actually based on increased levels of VEGF. "So the main message of our study is that the increased breast cancer risk is not only a consequence of the multiple pregnancy itself because of high hormone levels, but that the risk of breast cancer may already be elevated prior to conception in women who have the potential -- the 'maternal trait' -- to develop a multiple pregnancy from all transferred embryos."


'/>"/>

Contact: Christine Bauquis
Christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

Related medicine news :

1. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
2. 62 percent of men and 37 percent of women over the age of 65 are sexually active
3. Obese White Women Shying Away From Colon Cancer Screening
4. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
5. Timing pregnancy an important health concern for women
6. White Women Make Up Bulk of Assisted-Living Residents
7. Stress contributes to cognitive declines in women with breast cancer, researcher says
8. Women Less Apt Than Men to Get Recommended Daily Exercise
9. Overweight Pregnant Women at Higher Risk for Complications
10. Women With Older Partners More Often Admitted to Nursing Homes
11. Research shows efficacy of treatment model developed at Women & Infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... law firm headquartered in Houston, is pleased to announce their expansion to the ... affordable housing experience, directors Alysse Hollis and Ronald Bell, and of counsels, John ...
(Date:7/20/2017)... ... ... Team Type 1 Foundation, a nonprofit organization pursuing a global mission of ... up with a Microsoft Corp. employee-led hackathon team for the 2017 Microsoft One Week ... Type 1’s mission overlaps seamlessly with Microsoft’s mission to empower every person and every ...
(Date:7/20/2017)... ... July 20, 2017 , ... Girl Up Campaign Director, Melissa ... legislation in support of providing girls access to education in refugee settings. In May, ... “Protecting Girls’ Access to Education in Vulnerable Settings Act.” Yesterday, companion legislation was ...
(Date:7/20/2017)... ... July 20, 2017 , ... TCGRx announced today ... existing adherence automation lines. The ATP® Mini and InspectRx® Mini are ... standard products, but at a size and price point that can help pharmacies ...
(Date:7/20/2017)... ... July 20, 2017 , ... With ... 2014, top travel insurance solution company VisitorsCoverage Inc. has launched TMQuotes, a new ... international travel insurance products online, under their own brand. The online marketplace bridges ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... , July 11, 2017  Bayer has awarded grants ... countries as part of its prestigious Bayer Hemophilia Awards Program ... of Philadelphia and Uniformed Services University ... are among the winners. Grant recipients were announced last night ... Hemostasis (ISTH) 2017 Congress, Berlin, Germany . ...
(Date:7/11/2017)... 2017  Sysmex America, Inc., a leading provider ... as well as middleware information systems technology, today ... quality assurance easier and more risk free than ... for the innovation that it delivers to the ... assurance processes to a new level with automated, ...
(Date:7/11/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... on the development of oral drug delivery systems, announced ... has agreed to schedule an End-of-Phase II meeting with ... its oral insulin capsule ORMD-0801 in the treatment of ... and secondary endpoints by indicating a statistically significant lowering ...
Breaking Medicine Technology: