Navigation Links
Women have stronger immune systems than men and it's all down to a single chromosome
Date:9/27/2011

As anyone familiar with the phrase 'man-flu' will know women consider themselves to be the more robust side of the species when it comes to health and illness. Now new research, published in BioEssays, seems to support the idea. The research focuses on the role of MicroRNAs encoded on the X chromosome to explain why women have stronger immune systems to men and are less likely to develop cancer.

The research, led by Dr Claude Libert from Ghent University in Belgium, focused on MicroRNA, tiny strains of ribonucleic acid which alongside DNA and proteins, make up the three major macromolecules that are essential for all known forms of life.

"Statistics show that in humans, as with other mammals, females live longer than males and are more able to fight off shock episodes from sepsis, infection or trauma," said Libert. "We believe this is due to the X chromosome which in humans contains 10% of all microRNAs detected so far in the genome. The roles of many remain unknown, but several X chromosome-located strands of microRNA have important functions in immunity and cancer."

Dr Libert's team proposes that the biological mechanisms of the X chromosome have a strong impact on an individual's genes, known as genetic imprinting, which gives an immunological advantage to females. To develop their hypothesis the team produced a detailed map of all described microRNAs which have a role in immune functions and cancer in both human and mouse X chromosomes.

"We believe this immunological advantage is due to the silencing of X-linked genes by these microRNAs," said Libert. "Gene silencing and inactivation skewing are known mechanisms which affect X-linked genes and may influence X-linked microRNAs in the same way."

This genetic silencing leaves males at an immunological disadvantage as a male has only one X-chromosome. The Y-Chomosone contains fewer genes so if the genes involved in immunity are silenced maternally the male is left with no compensating genetic information.

"How this unique form of genetic inheritance influences X-chromosone linked microRNAs will be a challenge for researchers for years to come," concluded Libert, "not only from an evolutionary point of view, but also for scientists investigating the causes and cures of disease."


'/>"/>

Contact: Ben Norman
Lifesciencenews@wiley.com
44-012-437-70375
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Company Invites Women to STOP PMS - Take the 10-Minute Challenge
2. LifestyleMom.com and the LifestyleMom Radio Cafe Aim to Help Women Create a Family Life and "Me Life" That They Truly Love
3. Women More Likely to Fail Treatment for Atrial Fibrillation
4. Diabetes drug ups risk for bone fractures in older women
5. Womens Heart Disease Awareness Still Lacking
6. Cyndi Lauper, Lady Gaga Put Spotlight on Women and HIV
7. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
8. Womens Dermatologic Society Marks 35th Anniversary with Release of Unprecedented Book of Wisdom and Inspiration
9. Few Women at High Risk for Breast Cancer Take Tamoxifen
10. Diane von Furstenberg Establishes The DVF Awards to Recognize Outstanding Women Leaders
11. YazTalk Warns Women of Life Threatening Side Effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2017)... ... July 26, 2017 , ... Isodiol International Inc. (CSE: ISOL) ... in the development of pharmaceutical and consumer products, announces the operational numbers of ... 2017. Iso International LLC recorded unaudited fiscal Q1 profits of $897,596 based on ...
(Date:7/26/2017)... ... July 26, 2017 , ... The number of adults 65 years or ... ways to improve asthma control in the population are not well described. In a ... Practice), an official journal of the American Academy of Allergy, Asthma & Immunology (AAAAI), ...
(Date:7/25/2017)... ... July 25, 2017 , ... ... of their partnership to provide the Pharmacist eCare Plan to Computer-Rx ... the country with the ability to develop the Pharmacist eCare Plan, a shared ...
(Date:7/25/2017)... ... July 25, 2017 , ... ... provider in the United States, today announced its partnership with financial technology company, ... , The foundation of the solution lies within Hyosung’s superior ATMs, assisted self-service ...
(Date:7/25/2017)... ... ... SignatureCare Emergency Center – South Austin is treating both adult and pediatric patients ... The Emergency Room opened early March, making it the first SignatureCare Emergency ... are running smoothly,” said Aaron Braun, SignatureCare Emergency Center’s Chief Medical Officer. “We’re glad ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... , July 10, 2017 Locus Biosciences ... Note to support the development of CRISPR-Cas3 antimicrobial therapeutics. ... Limited, a leading Chinese Internet services provider, and joined ... advance multiple infectious disease product programs targeting antibiotic resistant ... Founded by Dr. Rodolphe Barrangou ...
(Date:7/5/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ... clinical-stage pharmaceutical company focused on the development of oral drug ... the Israel Securities Authority to dual-list its common stock on ... commence trading on the TASE on July 12, 2017 under ... the Company, it is expected that Oramed will be included ...
(Date:7/1/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... call will be broadcast live over the Internet on Thursday, ... release detailing the quarterly results will be made available at ... The live audio webcast can be accessed via ... will be archived for replay following the conference call. ...
Breaking Medicine Technology: