Navigation Links
Women have higher rate of spontaneous clearance of hepatitis C virus
Date:9/12/2013

A study of patients infected with acute hepatitis C virus (HCV) infection found that women had higher rates of spontaneous viral clearanceundetectable levels of the virus without initiating drug therapy. Findings published in Hepatology, a journal of the American Association for the Study of Liver Diseases, indicate that the gene IL28B (rs12979860) and HCV genotype 1 are also independent predictors of spontaneous HCV clearance.

In 2011, there were 1,229 cases of acute HCV reported to the Centers for Disease Control and Infection (CDC), which represents a 44% increase over 2010. Medical evidence indicates that 25% of those with acute HCV spontaneously clear their infection. Previous prospective studies link female sex, immune responses, neutralizing antibodies and genetics to viral clearance.

"Knowledge of acute HCV clearance is limited given that patients are typically asymptomatic during the initial stages of infection and at-risk populations, such as people who inject drugs, are often marginalized," explains lead author Dr. Jason Grebely at The Kirby Institute, University of New South Wales in Australia. "Our research aims to advance understanding of time to and predictors of HCV clearance to improve early therapeutic intervention options."

Researchers used data from the InC3 Studya collaboration of nine prospective studies from Australia, Canada, the Netherlands, and the U.S. funded by the National Institutes of Health and led by Professor Kimberly Page from the University of California San Franciscowhich included participants with HCV and human immunodeficiency virus (HIV) who were recruited between 1985 and 2010. The present study included 632 individuals diagnosed with acute HCV with 35% of the group being female and 82% Caucasian. Roughly 96% of participants had injected drugs, 47% were infected with HCV genotype 1 and 5% were co-infected with HIV.

Results show that 173 of the 632 participants had spontaneously cleared the virus during follow-up. At one year post-infection, 25% had HCV clearance. The average time to clearance among those who cleared HCV was 16.5 weeks, with 34%, 67% and 83% demonstrating clearance at 3, 6 and 12 months, respectively.

"Our findings indicate that females, those with the IL28B gene, and those with HCV genotype 1 are independent predictors of spontaneous clearance of acute HCV," concludes Prof. Kimberly Page. "Further research is necessary to understand the effect of sex in controlling HCV infection."


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related medicine news :

1. Isbel™ Invites Women to Pin Their Fantasy #inthemood Locales
2. Honoring a True Champion for Women’s Health and Rights
3. Study uncovers value of mammogram screening for younger women
4. ACR, SBI on cancer study: More breast cancer screening needed in younger women
5. Diet Plans For Women to Lose Weight – “30 Days To Thin” Teaches People How to Lose Weight Naturally – Vinamy
6. Women Strength Training
7. How “Lift Like A Girl” Helps Women Strengthen Body – V-kool
8. Certified Nurse Midwives of Women's Excellence in Midwifery Now Seeing Teens for Gynecological Care in Lake Orion and Clarkston, Michigan Locations
9. Women Voted The Valley Hospital as America’s Best Hospital for Patient Experience
10. Data suggests Abbotts test may help more accurately diagnose heart attacks in women
11. Women's Excellence in Midwifery Now Offering Natural Family Planning Consultations at Lake Orion and Clarkston, Michigan Locations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... A revolution is underway. Brooklyn-based ... experience for the millions of people who require these medical transport services annually. ... through the use of technology. Now, SmartEMS has put forth an industry-changing app ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), ... company,s second affiliate in Latin America . ... ... Colombia ... ...
(Date:6/23/2016)... 2016 The vast majority of dialysis patients ... Treatments are usually 3 times a week, with treatment ... travel time, equipment preparation and wait time.  This regimen ... for patients who are elderly and frail.  Many elderly ... rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: