Navigation Links
Women fare better than men with metastatic colorectal cancer -- are hormones helping?
Date:9/29/2009

PHILADELPHIA Younger women with metastatic colorectal cancer lived longer than younger men. However, this survival advantage disappeared with age, suggesting a benefit from estrogen or other hormones, according to results of a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"We've known for a while that estrogen prevents colorectal cancer, but this is the first study to suggest it may improve outcomes once you have colorectal cancer," said Heinz-Josef Lenz, M.D., co-director of gastrointestinal oncology and colorectal cancer at the University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine.

Using the Surveillance, Epidemiology and End Results registry, Lenz and colleagues screened 52,882 patients who had metastatic colorectal cancer between 1988 and 2004.

Women age 18 to 44 years had significantly longer survival than men at 17 months compared with 14 months. However, older women had significantly shorter overall survival at seven months compared with nine months.

Lenz said these results suggest that estrogen levels may be playing a significant role in prognosis. James Abbruzzese, M.D., chair of gastrointestinal medical oncology at the University of Texas M. D. Anderson Cancer Center and a deputy editor of Clinical Cancer Research, agreed that hormones may certainly play a role, but says a look at the data broken down by year is also intriguing. Specifically, those diagnosed after 2000 have improved survival; those diagnosed before 2000 had a less pronounced survival advantage.

"In terms of the chemotherapy we have available, since 2000 the regimens employ more agents and have become much more aggressive. Therefore, it may be expected to inhibit normal hormonal cycles leading to lower hormonal levels in these women, so other factors may be playing a role as well. It may not just be hormones," said Abbruzzese.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert  

Related medicine news :

1. Boston University School of Medicines black womens health study receives $9.1 million award
2. Women who make poor shoe choices at risk for foot pain later in life
3. Autoimmune Disorder Linked to Stroke, Heart Attack in Women
4. More Women Having Other Breast Removed
5. Irregular Heartbeat Risk Higher in Women With Type 2 Diabetes
6. Scientists Discover How Chemo Can Make Women Infertile
7. More women choosing to remove healthy breast after cancer diagnosis
8. Women With Atrial Fibrillation Face Rougher Road Than Men
9. Free Upcoming Program Scheduled to Help Remove Barriers To Early Cervical and Breast Cancer Diagnosis for Local Women
10. A Staggering 7 Out of 10 Women Facing Breast Cancer Are Never Told of Their Options
11. Women living in group homes need to learn to make decisions about leisure time to enrich their lives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Women fare better than men with metastatic colorectal cancer -- are hormones helping?
(Date:8/23/2017)... ... August 23, 2017 , ... Silicon Valley Hair Institute, a leading ... archive organized month-by-month. The new rotation of archived blog posts can provide a wide ... information about hair transplantation can review details online and then reach out for a ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... American Academy of Orthopaedic Surgeons , points out that therapeutic modalities (physical therapy) ... or injury. According to the report, a wider scope of physical therapy options ...
(Date:8/22/2017)... , ... August 22, 2017 , ... The Women’s Choice ... awarded Zyclear Migraine Relief with the 2017 Women’s Choice Award. The identification by women ... that 3 out of 4 migraine sufferers are women. In a survey taken by ...
(Date:8/22/2017)... ... August 22, 2017 , ... ... to announce the addition of Zack Tisch as the firm’s new Consulting Services ... healthcare IT consulting firm’s national accounts, from assisting clients with initial vendor selection ...
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... Nurses at ... acres at picturesque Babcock Cove, recently received training and certification in Closed Pulse ... which has a prestigious five-star rating from the Centers for Medicare and Medicaid Services, ...
Breaking Medicine News(10 mins):
(Date:8/23/2017)... , Aug. 23, 2017 DarioHealth Corp. ... with mobile health and big data solutions, announced ... placement offerings with domestic and non-U.S. investors for ... stock and shares of the Company,s newly designated ... placement offerings. Current shareholders accounted for 58% of ...
(Date:8/17/2017)... MJAC2017 , the premier cannabis event devoted to retail ... leading lineup. MJAC2017 is proud to ... in the development of pharmaceutical and consumer products, will be ... Green Organic Dutchman are gold sponsors for the event, joined ... ...
(Date:8/15/2017)...   Mostyn Law and Gulf Coast Regional Blood Center ... . The Mostyn Law family has had 3 members ... why Mostyn Law is partnering with Gulf Coast Regional ... appreciation. Blood supplies are running low. Gulf Coast Regional ... needs in August. That is why the blood center reached out ...
Breaking Medicine Technology: