Navigation Links
Women fare better than men, but need more blood after kidney cancer surgery
Date:5/15/2012

DETROIT Women do better than men after surgical removal of part or all of a cancerous kidney, with fewer post-operative complications, including dying in the hospital, although they are more likely to receive blood transfusions related to their surgery.

But Henry Ford Hospital researchers who documented these gender differences can't say why they exist.

The results of the new study, based on population samples from throughout the U.S., will be presented this week at the American Urological Association's Annual Meeting in Atlanta.

"This is a controversial area," says Quoc-Dien Trinh, M.D., a Fellow at Henry Ford Hospital's Vattikuti Urology Institute and lead author of the study.

"While the effects of gender on the outcome of many types of surgery, including removal of the bladder, have been demonstrated and widely debated, the association between gender and surgical outcomes of nephrectomy (kidney removal) is not well understood."

Physical differences between genders can explain different outcomes in some types of surgery, and have been shown and discussed in several earlier studies, Dr. Trinh says. "But this is hard to explain for nephrectomies. There is no clear-cut anatomical difference between men and women that would explain why it's easier or harder in one sex than the other."

Surgical removal of part or all of a diseased kidney, whether using traditional "open" techniques or less-intrusive laparoscopic procedures, is the standard of care for kidney cancer and the only curative treatment.

Using nephrectomy data from 1998 through 2007, the most recent available from the Health Care Utilization Project's Nationwide Inpatient Sample (NIS), "we tested the rates of blood transfusions, extended length of stay (beyond the median of five days), in-hospital mortality, as well as complications during and after surgery, separated by gender," Dr. Trinh says.

Of the total 48,172 cases that were identified and examined, 18,966 (39.4 percent) were female. The mean age for the women was 62.7 years; for the men, 61.8 years.

While no significant gender-related differences were found in complications during surgery and length of hospital stay after surgery, the Henry Ford Hospital researchers found that women:

  • Were less likely than men (14.6 percent vs. 17.1 percent) to have complications after nephrectomy. These included digestive problems, hemorrhage, cardiac complications and infections.
  • Were less likely to die while in the hospital (0.6 percent vs. 0.8).
  • Were more likely to have blood transfusions than men (11.5 percent vs.9.2 percent).

The differences were most pronounced after partial removal of a cancerous kidney using open surgical techniques.

Because researchers didn't have specific data on the kidney tumors in each individual case, exactly why these differences were found couldn't be determined, Dr. Trinh says, adding, "It is entirely possible that women have smaller tumors, so there are fewer complications."

As to the higher rates of blood transfusion in female patients, Dr. Trinh says the reason or reasons remain unknown.

"The threshold for transfusion could be different between men and women," he says. "We usually transfuse based on clinical decisions: we look at the patients, how they're doing, and make judgments. There are no clear-cut guidelines.

"In the end, women are transfused more often. Is it because they bleed more often? Are they transfused more liberally than men? We don't have the data to answer this."

While these differences remain to be explored and determined, the fact that they exist, and have now been documented, is a step forward in the treatment of kidney cancer.

"Insight into the effect of gender on major urologic oncology procedures," Dr. Trinh says, "is critical in reducing disparities in care and improving patient outcomes."


'/>"/>

Contact: Krista Hopson
khopson1@hfhs.org
313-874-7207
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Company Invites Women to STOP PMS - Take the 10-Minute Challenge
2. LifestyleMom.com and the LifestyleMom Radio Cafe Aim to Help Women Create a Family Life and "Me Life" That They Truly Love
3. Women More Likely to Fail Treatment for Atrial Fibrillation
4. Diabetes drug ups risk for bone fractures in older women
5. Womens Heart Disease Awareness Still Lacking
6. Cyndi Lauper, Lady Gaga Put Spotlight on Women and HIV
7. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
8. Womens Dermatologic Society Marks 35th Anniversary with Release of Unprecedented Book of Wisdom and Inspiration
9. Few Women at High Risk for Breast Cancer Take Tamoxifen
10. Diane von Furstenberg Establishes The DVF Awards to Recognize Outstanding Women Leaders
11. YazTalk Warns Women of Life Threatening Side Effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... ... Bellus Medical, a leader in medical aesthetics, recently acquired ... photodynamic cosmetics (PDC). , Allumera® is the first PDC cream specifically formulated to ... minimize the appearance of pores – all with minimal downtime and results that ...
(Date:4/25/2017)... ... ... A stressful work environment can hurt the physical and emotional health of employees. ... workplace. The goal of Clearview Resolution Services has always been to help others, starting ... will be shutting down the office early on Fridays. The Clearview team will use ...
(Date:4/25/2017)... Lutz, FL (PRWEB) , ... April 25, 2017 , ... ... transform their smiles by using Invisalign® in Lutz, FL. With the help ... oral health and aesthetics with fewer potential complications, more discretion and less pain. ...
(Date:4/25/2017)... ... ... Back Pain Centers of America (BPC), which connects people searching ... area, announces the launch of a new and proprietary customer relationship management (CRM) system ... physicians to help them with back or neck pain and helps to match them ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... Emergency Physician ... book of the Outlier Leadership Series, Outliers in Writing, set to publish in summer ... of Emergency Medicine at the University of Arizona College of Medicine. He also serves ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Inc ., a digital health company focused on modernizing and ... $25 million in Series B funding led by Qiming US ... Seattle that is part of a broader family ... included participation from SR One , who led ZappRx,s ... Google Ventures). As part of the financing, Mark McDade ...
(Date:4/20/2017)... April 20, 2017 NeuroVive Pharmaceutical AB ... announced positive preclinical results demonstrating anti-fibrotic effects ... non-alcoholic steatohepatitis (NASH), in an additional well-validated ... NV556 has previously shown similar anti-fibrotic effects ... NeuroVive,s scientists present novel data demonstrating anti-fibrotic ...
(Date:4/19/2017)... YORK , April 19, 2017 The Mobile ... to showcase a healthy CAGR during the forecast period ... type in the global digital mobile X-Ray devices market, which ... Mn in 2017, expanding at a CAGR of 7% over ... absolute $ opportunity of more than US$ 100 Mn in ...
Breaking Medicine Technology: