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Women advised to avoid ZEN bust-enhancing supplements because of possible cancer risk
Date:12/8/2011

ncreased ZEN levels in their serum.

"In fact the European Union has banned using ZEN to fatten up cattle, a technique used in the USA since 1969, because of its links with precocious puberty" says Professor Fentiman.

"Recently it has been suggested that some ZEN derivatives can increase the growth of hormone-dependent breast tumours. It has also been reported that, depending on the dose, ZEN can either promote or prevent breast cancer. So the jury on whether its links with breast cancer are positive or negative is well and truly out at this stage."

The authors drew a number of conclusions from their review:

  • There is a lack of information on the human metabolism of ZEN and disagreement on the mechanisms of ZEN oestrogenic action in human tissue.
  • The presence of this mycoestrogen in cereals, milk, and meat, and the possibility of ZEN involvement in the development of new breast tumours, warrant further investigation.
  • Future studies should investigate the effects of ZEN on the growth stimulation of hormone-dependent cancers and identify the key genes that promote hormone-dependent cancers.
  • ZEN promotes programmed cell death and reduces the proliferation of cancer cells when administered at certain doses.
  • Although ZEN is a common diet toxic mycoestrogen, the potential risk to human health appears to only occur when it is absorbed in concrete concentrations or over a long period of time.
  • A molecular biomarker of dietary exposure to ZEN and its derivatives will allow the detection and control of harmful food intake.
  • The interaction of ZEN with anti-oestrogens and anticancer agents and antioxidants requires further investigation.

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Contact: Annette Whibley
annette.wizard@gmail.com
Wiley-Blackwell
Source:Eurekalert

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