Navigation Links
Women advised to avoid ZEN bust-enhancing supplements because of possible cancer risk
Date:12/8/2011

Women who use bust-enhancing dietary supplements containing the mycoestrogen zearalenone (ZEN), a naturally occurring toxin that widely contaminates agricultural products, could be increasing their risk of breast cancer. That is the warning from breast health experts in a paper published online ahead of print publication in the January issue of IJCP, the International Journal of Clinical Practice.

"No clinical trials have been published on the use of potent oestrogens like ZEN in bust-enhancing products and their use should be discouraged because of the lack of evidence of their long-term safety" says Professor Ian Fentiman, consultant breast surgeon at Guy's and St Thomas' NHS Foundation Trust, London.

The use of ZEN to increase bust size is just one of the key concerns raised by the review focussing on the affects of ZEN and its derivatives on the human reproductive system and breast cancer. It also included the use of ZEN to fatten up livestock, its use in hormone replacement therapy and oral contraceptives, its links with premature puberty and its possible effects on breast cancer.

"ZEN is a toxic non-steroidal mycoestrogen produced by fungi that widely contaminates agricultural products, such as crops, eliciting oestrogenic responses by mimicking the female sex hormones" explains Professor Fentiman.

Using ZEN in animal feed has been associated with a wide range of reproductive anomalies in livestock, including diminished fertility and infertility, reduced litter size and smaller offspring and negative effects on the reproductive organs.

International studies have suggested links between consumption of ZEN-fed animals and products and precocious (early) puberty in young females.

These include an epidemic of premature breast development and early puberty in Puerto Rico, linked to dairy and meat products, and studies from Hungary and Italy where female children with precocious puberty had increased ZEN levels in their serum.

"In fact the European Union has banned using ZEN to fatten up cattle, a technique used in the USA since 1969, because of its links with precocious puberty" says Professor Fentiman.

"Recently it has been suggested that some ZEN derivatives can increase the growth of hormone-dependent breast tumours. It has also been reported that, depending on the dose, ZEN can either promote or prevent breast cancer. So the jury on whether its links with breast cancer are positive or negative is well and truly out at this stage."

The authors drew a number of conclusions from their review:

  • There is a lack of information on the human metabolism of ZEN and disagreement on the mechanisms of ZEN oestrogenic action in human tissue.
  • The presence of this mycoestrogen in cereals, milk, and meat, and the possibility of ZEN involvement in the development of new breast tumours, warrant further investigation.
  • Future studies should investigate the effects of ZEN on the growth stimulation of hormone-dependent cancers and identify the key genes that promote hormone-dependent cancers.
  • ZEN promotes programmed cell death and reduces the proliferation of cancer cells when administered at certain doses.
  • Although ZEN is a common diet toxic mycoestrogen, the potential risk to human health appears to only occur when it is absorbed in concrete concentrations or over a long period of time.
  • A molecular biomarker of dietary exposure to ZEN and its derivatives will allow the detection and control of harmful food intake.
  • The interaction of ZEN with anti-oestrogens and anticancer agents and antioxidants requires further investigation.

'/>"/>
Contact: Annette Whibley
annette.wizard@gmail.com
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Freshman womens binge drinking tied to sexual assault risk
2. Binge drinking by freshman women tied to sexual assault risk, according to new research
3. Hispanic Women More Likely to Die of Breast Cancer
4. Stress reduction and mindful eating curb weight gain among overweight women
5. Being overweight not such a stigma for African American women
6. Rotating night shift work linked to increased risk of Type 2 diabetes in women
7. Rotating Shift Work May Boost Womens Diabetes Risk
8. Research With Worms May Shed Light on Womens Fertility
9. Advanced age should not deter women from breast reconstruction after cancer
10. LSUHSC research finds many women not receiving recommended breast cancer adjuvant treatment
11. Poorly contracting uterus in diabetic women increases risk of caesarean birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... communities in the greater Dallas, Miami, and Raleigh regions, is organizing an extended ... overcome a rare and deadly chromosome abnormality. , After struggling since birth with ...
(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
(Date:10/4/2017)... , Oct. 4, 2017  According to the Centers for Disease ... end of October . PhysicianOne Urgent Care is helping communities across ... Westchester, NY , by offering no-cost* flu shots through the end ... mandated by certain health insurance regulations. ... The best time to get a flu shot is by the end ...
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
Breaking Medicine Technology: