Navigation Links
Women Are at Greater Risk Than Men of Graft Loss After Undergoing Liver Transplantation for Hepatitis C-related Liver Disease
Date:10/29/2009

ALEXANDRIA, Va. and BOSTON, Oct. 29 /PRNewswire/ -- Although women with chronic hepatitis C virus (HCV) infection are at lower risk for developing cirrhosis, researchers who compared outcomes for men and women after having liver transplantation found that women have a significantly increased risk of overall graft loss and graft loss from recurrent HCV than men. "Given the higher rate of graft losses due to recurrent HCV and higher risk of developing advanced HCV, our results highlight the need for close monitoring of HCV disease progression after liver transplantation and the appropriate timing of interventions, such as HCV treatment," said Jennifer Lai, MD, lead investigator for the study.

In this study to be presented at the annual meeting of the American Association for the Study of Liver Diseases, data were analyzed from four experienced liver transplant centers in the United States, which included 850 patients who underwent liver transplantation from March 2002 through December 2007 for HCV-related liver disease. Not only were women at greater risk of graft loss from all causes and recurrent HCV, but they experienced increased rates of advanced HCV-related liver disease compared with men.

These differences were not explained by differences in baseline recipient or donor characteristics, or rates of acute rejection after transplantation. "However," said Dr. Lai, "understanding the factors contributing to this gender difference is critical to improving post-transplant outcomes for all patients with HCV."

Based on this multicenter study, further studies are needed to evaluate modifiable donor factors and post-transplant therapeutics that influence outcomes. There may be a future role for gender-specific models to optimize post-transplant outcomes in women. "Whether we should have a more intensive approach to monitoring for and management of recurrent HCV would improve outcomes in women will need to be established in future studies," said Dr. Lai.

In addition, Dr. Lai discussed future research on this topic, "We found recipient age to be a stronger predictor of outcome for women than for men, and we noted that women had higher rates of having a sex-mismatch donor liver than men. A more in depth analysis of the role of recipient-donor sex mismatch is planned. In addition, we found that women had significantly increased rates of acute rejection and although this factor did not account for differences in graft outcomes in our study, we believe sex differences in frequency of rejection and response to rejection treatment warrant further study."

Abstract title:

Hepatitis C virus (HCV) infected females are at higher risk of graft loss after liver transplantation (LT): A multicenter cohort study

About the AASLD

AASLD is the leading medical society focused solely on advancing the science and practice of hepatology and represents more than 3,300 practitioners, researchers, and allied health professionals worldwide. Founded by physicians in 1950, AASLD has upheld the standards of the profession and fostered research that generates treatment options for the millions of patients with liver diseases.

This year's Liver Meeting, held in Boston, Massachusetts, October 30 - November 3, will bring together more than 7,000 researchers from 55 countries. A pressroom will be available from October 31 at the annual meeting. For copies of abstracts and press releases, or to arrange for pre-conference research interviews contact Gregory Bologna at 703-299-9766. To pre-register, call Ann Tracy at 703-299-9766.

Press releases, additional information for the media, and all abstracts are available online at www.aasld.org.

    Media Contact: Gregory Bologna
    703/299-9766
    gbologna@aasld.org

    Press Room: October 31 - November 3, 2009
    Hynes Convention Center, Room 209
    Telephone: (617) 954-2827

    Researcher: Jennifer Lai, MD
    Email: jennifer.lai@ucsf.edu
    Phone: (415) 443-6251

This release was issued through The Xpress Press News Service, merging e-mail and satellite distribution technologies to reach business analysts and media outlets worldwide. For more information, visit http://www.XpressPress.com

SOURCE American Association for the Study of Liver Diseases (AASLD)


'/>"/>
SOURCE American Association for the Study of Liver Diseases (AASLD)
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Just Released -- New Poll: Healthcare Through Womens Eyes
2. Breast Abnormality Follow-Up Often Later in Black Women
3. Study finds delay in follow-up among African-American women receiving abnormal breast finding
4. Survival after heart attack improves in younger women
5. Is Smoking Tougher on Women?
6. October 2009 Mayo Clinic Womens HealthSource Highlights Ductal Carcinoma In Situ, New Hearing Aid Options and Self-Acceptance
7. Keystone Mercy Health Plan Initiative Brings Cancer Screenings to Underserved Women in Their Communities
8. CARE President to Speak at Inaugural Event of New Leadership Series on Women and Global Development
9. Women and Men Face Off: Who Can Stand the Pain?
10. Obesity May Affect Fertility in Young Women
11. Photos: Avon Foundation for Women Celebrates Breast Cancer Awareness Month
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... More than ... so it is not surprising that bariatric surgery has received increased attention in recent ... explains. Of course, when it comes to weight loss, most people are familiar with ...
(Date:5/27/2016)... ... May 27, 2016 , ... Two director-level employees of Horizon Blue Cross Blue ... Industry (TWIN) 2016 honorees. The award recognizes businesswomen who excel in their fields ... Director of the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ Health ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... An influential ... for a third time to shed lights on the variety of topics detailing why ... stories, “Nurse Appreciation” tackles why this career has gone from being in a major ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... the factors of a stroke, which we as a society can control and change. ... a stroke occurs nearly every 40 seconds within the United States. Plus, with an ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response to ... who are unaware of the plight of aphasia. In collaboration with the American ... Awareness” campaign. , The link between stroke and aphasia is relatively unknown, but ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... HILDEN , Germany and ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt ... into a licensing and co-development agreement with Therawis Diagnostics GmbH ... project will be to develop and market PITX2 as a ... and other high-risk breast cancer patients. "We are ...
(Date:5/25/2016)... NORTH CHESTERFIELD, Va. , May 25, 2016 ... commercially-available next-generation sequencing test for wounds and infections. ... fungi, ALL parasites, and select viruses. The test ... infected area. David G. ... advanced molecular testing to facilitate wound healing: "We ...
(Date:5/24/2016)... , May 24, 2016 ... den Markt gebracht, die es Ärzten erlaubt, ihre ... zu behandeln: MDLinking kombiniert Live Streaming mit einer ... Umfeld zu kommunizieren. Mediziner in Europa, Afrika, Asien ... sich bereits für die Plattform registriert. ...
Breaking Medicine Technology: