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Women 40% less likely to die after TAVI than men
Date:8/28/2012

Munich, Germany August 27 2012: Women with severe aortic stenosis are 40% less likely to die after transcatheter aortic valve implantation (TAVI) than men, reveals the latest data from the largest study to date of gender differences in outcomes after TAVI. The findings were presented at ESC Congress 2012 by Professor Karin Humphries from St. Paul's Hospital.

More than 1.5 million people in the US suffer from aortic stenosis, a progressive disease where the aortic valve becomes obstructed, leading to life-threatening heart problems. If left untreated, half of all patients do not survive for more than two years after the initial onset of symptoms. Traditionally, treatment involves open heart surgery to replace the diseased valve; however in frail and elderly patients the surgery is highly risky and sometimes simply not possible to perform.

A groundbreaking non-surgical treatment, known as transcatheter aortic valve implantation (TAVI), has shown considerable promise in these high-risk patients. Pioneered in Canada in 2005 by interventional cardiologist Dr John Webb and his team at St. Paul's Hospital in Vancouver, the TAVI procedure is minimally invasive and does not require major surgery.

Since the first successful valve implantation by Dr Alain Cribier from France, more than 50,000 procedures have been performed worldwide. To study the efficacy of the technique, researchers from the pivotal randomized trial, Placement of Aortic Transcatheter Valves (PARTNER) A, compared TAVI to traditional surgery and demonstrated patients did just as well with either procedure.

"The PARTNER trial also sparked considerable interest in gender differences," said Professor Humphries. "Women, at one year, were found to have lower mortality with TAVI when compared to men (1). However, the trial did not adjust for potential baseline differences between women and men. The US Food and Drug Administration's Circulatory Systems Devices Panel for the P
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Contact: European Society of Cardiology
press@escardio.org
33-049-294-8627
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3

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