Navigation Links
Woman's Recovery From Advanced Melanoma Could Help Guide Research
Date:3/7/2012

WEDNESDAY, March 7 (HealthDay News) -- Combining the immune-based drug ipilimumab with targeted radiation therapy improved one advanced melanoma patient's ability to fight the deadly skin cancer, a new study says.

The treatment triggered a strong immune response, which resulted in shrinkage of both the tumor treated with radiation as well as tumors located at distant locations in the body, according to the study, published in the March 8 issue of the New England Journal of Medicine.

The patient was followed for seven years, from her initial diagnosis of melanoma in 2004, through a series of treatments, to her eventual disease regression in April 2011.

According to health experts, this is a rare documented case of an immune response called the "abscopal effect" that can occur in cancer treatment.

Although the results were dramatic in this patient, one expert said such cases are isolated.

"Although this patient represents a successful outcome, it does not mean that this treatment approach will be as effective in other patients," said Dr. Craig Devoe, oncologist at the Monter Cancer Center, part of the North Shore-Long Island Jewish Health System, in Lake Success, N.Y. He was not involved in the study.

In this case, the patient had a preexisting immune response to an antigen called NY-ESO-1. This immune response occurs in certain cancer patients and they are more likely to respond to ipilimumab than others, explained the scientists at the Ludwig Institute for Cancer Research and Memorial Sloan-Kettering Cancer Center in New York City.

"The use of radiation therapy modulated the patient's immune system, resulting in an increased antibody response to one portion of the NY-ESO-1 protein, as well as increased antibody responses to other antigens," research leader Dr. Jedd Wolchok said in a Ludwig Institute news release. Wolchok is associate attending physician and director of Immunotherapy Clinical Trials at Memorial Sloan-Kettering, and director of the Ludwig Institute/Cancer Research Institute Cancer Vaccine Collaborative.

At the same time that the therapy was evoking this strong immune-system response, "the radiation lowered the level of a population of [immunosuppressive] cells, allowing the immune system to function more robustly, leading to better recognition and control of the disease," Wolchok said.

This case report illustrates the power of harnessing the human immune system to fight cancer, the researchers said.

"The immune system differs in each of us," Wolchok said. "In studying one person's response, we were able to carefully investigate the clinical findings with in-depth laboratory studies, which suggested that a change in the immune system was vital to the successful results."

This case has sparked interest in clinical trials to test this treatment approach for melanoma and prostate cancer, the research team said.

Devoe agreed that the woman's successful treatment may offer intriguing new avenues of research.

"Dr. Wolchok and his team are outstanding researchers in the field of melanoma," Devoe said. "The immune system has been and continues to be one of the most important aspects of melanoma treatment."

Devoe believes the case of this one patient "does increase the evidence that the NY-ESO-1 protein is a very important immune system target and further study of this particular phenomenon is needed."

More information

The American Cancer Society has more about melanoma.

-- Robert Preidt

SOURCES: Craig Devoe, M.D., oncologist, Monter Cancer Center, North Shore-LIJ Health System, Lake Success, NY; Ludwig Institute for Cancer Research, news release, March 7, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug Seems to Speed Recovery After Traumatic Brain Injury
2. Being Fit Before Stroke May Aid Recovery
3. High levels of tau protein linked to poor recovery after brain injury
4. Recovery From Concussions in Young Athletes May Take Longer Than Thought
5. Painkiller Dependence Before Knee Surgery May Slow Recovery
6. Brain function involved in recovery of facial paralysis is different according to sex
7. Helping others helps teens stay on the road to addiction recovery
8. Dementia May Impede Stroke Recovery
9. Blood-pressure-lowering drug after stroke aids recovery, study finds
10. Commonly used supplement may improve recovery from spinal cord injuries
11. Common stimulant may speed recovery from general anesthesia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Woman's Recovery From Advanced Melanoma Could Help Guide Research
(Date:1/20/2017)... ... , ... "TransFlare 4K Mystique comes with 44 colorful mysterious transitions that are ... Austin - CEO of Pixel Film Studios. , TransFlare 4K Mystique contains 44 ... flare and light leak transitions have a very high-dynamic range for super smooth falloff. ...
(Date:1/20/2017)... ... 20, 2017 , ... “I Forgive You”: a fine examination of how God handles sin, ... creation of published author, Stephen Miller, who, for over ten long years has been waiting ... Born in Trinidad and Tobago, he has been serving the Lord for over twenty years, ...
(Date:1/20/2017)... ... ... “The Land of More and More”: a brilliant story for children ... the simple and achievable answer. “The Land of More and More” is the creation ... in Angola, Indiana where he works with the children’s ministry department. , Michael ...
(Date:1/19/2017)... ... January 19, 2017 , ... Wells Pharmacy Network announced ... their 503A compounding pharmacy located in Ocala, Florida. , Meeting the Needs ... throughout the United States for high-quality human anti-aging and wellness compounded medications, ...
(Date:1/19/2017)... ... January 19, 2017 , ... Remote ... recently unveiled impressive transportable capabilities with their iMedHD2™ Portable Teleultrasound System. ... to RMT technology that delivers HD, dynamic, streaming ultrasound images and video to ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , Jan. 20, 2017 Wells Specialty Pharmacy announces ... Howell Branch Rd in Winter Park, Florida ... Park . Operations have been consolidated into the 3796 ... also pleased to announce that Chad Tomlinson , former ... the Company effective immediately. Mr. Tomlinson is a Graduate of ...
(Date:1/20/2017)... , January 20, 2017 Avillion LLP, a ... of Mark Weinberg , MD MBA as Chief Medical Officer. ... USA . ... Dr Weinberg has spent more than 17 years as ... pharma companies to micro-cap biotech. Over the course of his career, ...
(Date:1/19/2017)... Jan. 19, 2017 The global immunomodulators ... by 2025, according to a new study by ... to be predominantly driven by high R&D investments ... large-scale production of new and therapeutically advanced drugs. ... drugs at an unprecedented rate into the immunomodulators ...
Breaking Medicine Technology: