Navigation Links
With muscle-building treatment, mice live longer even as tumors grow
Date:8/19/2010

In the vast majority of patients with advanced cancer, their muscles will gradually waste away for reasons that have never been well understood. Now, researchers reporting in the August 20 issue of Cell, a Cell Press Publication, have found some new clues and a way to reverse that process in mice. What's more, animals with cancer that received the experimental treatment lived significantly longer, even as their tumors continued to grow.

"This is the first demonstration that muscle mass plays a key role in cancer survival," said H.Q. Han of Amgen Research.

While it has long been recognized that this muscle wasting condition, known as cachexia, affects advanced cancer patients' quality of life, Han explained, its importance for survival had primarily been a matter of speculation. Nearly 30 percent of cancer-related deaths have been attributed to cachexia, but that was based on correlative evidence only. That is, there has seemed to be a connection in cancer patients between weight loss and mortality.

Still, cachexia had typically been considered a "multi-factorial" process with many causes. "That would make it hard to target," Han said. Indeed, few therapeutic options are available and efforts to treat this aspect of the disease haven't been top of mind. Given the new results, that could change.

The researchers suspected that a pathway known as ActRIIB might be involved. ActRIIB is what's known as an activin type 2 receptor. There was evidence to suggest that tumors secrete activin, such that circulating levels of the protein rise in those with cancer. Activin is closely related to another protein, called myostatin, which is known to be important in muscle. Animals lacking myostatin or taking treatments that block it grow bigger muscles. There was some evidence to suggest that activin blockers might have a similar effect.

Based on that hunch, the researchers treated mice with cancer and associated cachexia wi
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Arsenic shows promise as cancer treatment, Stanford study finds
2. Immune cells predict success of head and neck cancer treatment, U-M study finds
3. BHR Pharma Statement on Brain Injury Awareness Month - Better Awareness, Treatment, Research Needed Now
4. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
5. Longer Time Frame for Clot-Busting Drug May Help Beat Stroke
6. The Longer You Sit, the Shorter Your Life Span: Study
7. Women live longer but in worse condition
8. Diabetes patients admitted for acute exacerbations of COPD have longer hospital stay
9. Longer Antiviral Therapy Reduces Lung Transplant Complications
10. iStayYoung Launches – Live Longer, and Better. Free for Seniors 65+
11. Intervention program helps breast cancer patients live longer after recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Ticket Down announces that they ... Guinness International Champions Cup match between international soccer powerhouses ... on Sunday, July 27th. This well-known ticket ... SOCCER-2014 for added savings. , 2014 is turning out ... in North America. Countless international soccer teams have been ...
(Date:7/25/2014)... (GSA) the nation,s largest interdisciplinary organization ... chosen Heather M. Young, PhD, RN, FAAN, of ... recipient of the Doris Schwartz Gerontological Nursing Research ... Health Sciences Section, is given to a member ... sustained contribution to gerontological nursing research. , The ...
(Date:7/25/2014)... Island (PRWEB) July 25, 2014 Reproductive ... to announce that Dr. Kerri Luzzo, Lead Physician at ... Award" for her professional accomplishments in fertility care and ... , At the 10th Annual PBN Awards ceremony held ... Island, 40 of the most highly regarded, emerging leaders ...
(Date:7/25/2014)... The Little Gym of Houston will ... July 27 at Discovery Green in downtown Houston. The ... Pearland, Friendswood, Spring, The Woodlands, Sugarland-Missouri City, Kingwood, Bellaire ... “We’re thrilled to be attending and performing at the ... owns the Sugarland-Missouri City location. “We believe in the ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 AttorneyOne.com, a recognized ... latest information from the FDA on Ibuprofen and Oxcarbazepine ... that one lot of Ibuprofen and one lot of Oxcarbazepine ... due to mislabeled packaging. Oxcarbazepine is used for the treatment ... , The reason for the recall is that Lot ...
Breaking Medicine News(10 mins):Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Young earns GSA's 2014 Doris Schwartz Gerontological Nursing Research Award 2Health News:Dr. Kerri Luzzo of the Reproductive Science Center of Providence Receives “40 Under Forty Award" for Outstanding Professional Accomplishments and Community Outreach 2Health News:The Little Gym of Houston to Attend Houston Family Magazine’s Family Fun Fest 2014 2Health News:Ibuprofen and Oxcarbazepine Tablets Recalled: AttorneyOne Monitors and Keep Consumers Informed 2
... Texas, hospital go online with electronic health recordsNASHVILLE, ... (HMS) announced today that they and Cogdell Memorial ... Memorial selected HMS to supply a fully integrated ... the Snyder, Texas hospital closer to electronic health ...
... Jan. 7 The TV Teacher, LLC(TM) announces the,donation ... York City schools: Queens, Bronx, and Staten Island. , ... Beats(TM) was co-created,by Susan Ellis, a mother struggling to ... the alphabet. After an unsuccessful two years of,"traditional" ...
... Snow Jr., chairman and chief executive officer, Medco Health Solutions, ... the 27th Annual JPMorgan Healthcare Conference in San Francisco on ... Hotel, San Francisco, will begin at 8:30 a.m. PST (11:30 ... Richard J. Rubino, chief financial officer, and Robert S. Epstein, ...
... Mass., Jan. 7 Boston Scientific Corporation (NYSE: ... upcoming JP Morgan Health Care Conference in San Francisco.Jim ... on Wednesday, January 14th, beginning at approximately 12:00 p.m. ... President and Chief Financial Officer will join Mr. Tobin ...
... Trademark Office (USPTO) has registered Guru Program® as ... developed and honed by Tom Gable, of Gable ... USPTO language said the mark covered: consulting services ... legal and accounting services, health care, financial services, ...
... 7 Agito Networks, Inc.(TM), the,company delivering ... today,announced that Technology Marketing Corporation,s (TMC(R)) Unified,Communications ... Networks,RoamAnywhere(TM) Mobility Router(TM) as a recipient of ... Agito Networks, award-winning RoamAnywhere ...
Cached Medicine News:Health News:Cogdell Memorial Hospital Partners with Healthcare Management Systems 2Health News:Cogdell Memorial Hospital Partners with Healthcare Management Systems 3Health News:New York Schools Receive Program for Children with Autism 2Health News:Medco CEO to Present at the 27th Annual JPMorgan Healthcare Conference 2Health News:Guru Program Pioneered by Tom Gable Receives Official Registration from USPTO 2Health News:Guru Program Pioneered by Tom Gable Receives Official Registration from USPTO 3Health News:Agito Networks' RoamAnywhere Mobility Router Wins Unified Communications Magazine's 2008 UC Excellence Award 2Health News:Agito Networks' RoamAnywhere Mobility Router Wins Unified Communications Magazine's 2008 UC Excellence Award 3Health News:Agito Networks' RoamAnywhere Mobility Router Wins Unified Communications Magazine's 2008 UC Excellence Award 4
(Date:7/25/2014)... PORTLAND, Ore. , July 25, 2014 /PRNewswire/ ... "Semler"), an emerging medical risk assessment company that ... monitoring patients and evaluating chronic diseases, today reported ... months ended June 30, 2014. ... productive for Semler," said Doug Murphy-Chutorian , ...
(Date:7/25/2014)... /PRNewswire-iReach/ -- Dr. Michael Gabriel of a prominent ... a recent study, which shows how grief in pregnancy may ... According to US News , ... likely than others to grow up overweight or obese, even ... were two specific types of stress that caused obesity: "Children ...
(Date:7/24/2014)... MADISON, Wis. , July 24, 2014 /PRNewswire/ ... provides specialty and compounded pharmaceuticals, announced that it ... sensitivity information unique to each individual based upon ... now possible by understanding the interaction between a ... "We,re very excited to provide this ...
Breaking Medicine Technology:Semler Reports Second Quarter 2014 Financial Results 2Semler Reports Second Quarter 2014 Financial Results 3Dr. Michael Gabriel of GPM Pediatrics, a Noted Staten Island Pediatrics Clinic, Comments on Study, Which Names Grief as a Cause of Obesity in Children 2Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 2Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 3
... 10 Bayer HealthCare announced today the recipients ... Nursing Fellowship (IHNF).  This global initiative, supported by Bayer, ... countries – areas where hemophilia-trained healthcare professionals are in ... countries ( Algeria , Brazil , Cameroon ...
... July 9 Pioneer Surgical Technology, Inc. recently expanded its Biologics ... their growing line of products that address bone and soft tissue repair. ... Mr. Shane ... with our ability to provide innovative biologic products and to compete with ...
Cached Medicine Technology:Bayer HealthCare Announces Recipients of 2010 WFH International Hemophilia Nursing Fellowship 2Bayer HealthCare Announces Recipients of 2010 WFH International Hemophilia Nursing Fellowship 3Bayer HealthCare Announces Recipients of 2010 WFH International Hemophilia Nursing Fellowship 4Pioneer® Surgical Expands Product Specialists to Support Growing Biologics Business 2
... be used in facilities where space is ... ventilation and gas delivery technologies with an ... and the functionality of the Draeger Infinity ... yourself a workplace environment that is a ...
... superior ventilation., ,The Aestiva/5 offers exceptional ... approach to anesthesia therapy., ,The Aestiva/5 ... an intensive care ventilator, saving you the ... into the OR. Its flexible ergonomic design ...
With its integrated design and superior build quality each Prima SP is custom built to meet your requirements....
A non-adhering hydrogel sheet dressing for use on all partial and full thickness wounds (excluding 3rd degree burns.) Hydrogel sheet contains 96% water and 4% insoluble cross-linked polyethylene oxid...
Medicine Products: