Navigation Links
Wistar researchers show targeting 'normal' cells in tumors slows growth
Date:11/16/2009

Targeting the normal cells that surround cancer cells within and around a tumor is a strategy that could greatly increase the effectiveness of traditional anti-cancer treatments, say researchers at The Wistar Institute.

In the Journal of Clinical Investigation published online November 16, they demonstrate the critical role for fibroblast activation protein (FAP), expressed by one type of these so-called "stromal" cells, in promoting tumor growth in mice. Genetically deleting or therapeutically targeting FAP significantly reduced the rate of tumor growth in mice by interrupting or blocking important signaling pathways and biological processes required for tumor growth, the Wistar team found.

"It's like taking away the soil from a seed that wants to grow," says senior author Ellen Pur, Ph.D., a professor in the Molecular and Cellular Oncogenesis Program at Wistar. "These results provide a proof-of-principle that targeting and modifying a tumor's microenvironment may be an effective approach to treating solid tumors."

Tumors are a complex mix of neoplastic cancer cells and normal cells inflammatory and immune cells, endothelial cells, fibroblasts, pericytes, and others, collectively known as stromal cells. In addition, a web-like extracellular matrix is created by the stromal cells, and its structure is important for supporting and nurturing tumor growth through molecular signaling pathways.

The Wistar team focused on fibroblasts and pericytes. In addition to synthesizing components of the extracellular matrix, fibroblasts associated with tumors also express FAP, a particular protease that cuts up other proteins while pericytes are important to the function of the new blood vessels that develop in tumors. FAP is expressed in 90 percent of all human epithelial (solid) cancers, and FAP expression is recognized as a marker for and is thought to play a role in cancer growth, but the mechanisms through which this occurs had
'/>"/>

Contact: Staci Vernick Goldberg
sgoldberg@wistar.org
215-898-3716
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel vaccine concept developed by scientists at the Wistar Institute
2. The Wistar Institute collaborates with the Coriell Institute to distribute cell lines
3. Los Angeles Times writer wins Wistar Institute Science Journalism Award
4. Wistar Institute team finds key target of aging regulator
5. Stanford researchers find culprit in aging muscles that heal poorly
6. UCLA researchers identify markers that may predict diabetes in still-healthy people
7. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
8. Bipolar disorder relapses halved by Melbourne researchers
9. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
10. High and mighty: first common height gene identified by researchers behind obesity gene finding
11. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2015)... June 02, 2015 The National ... Cade as a 2015-2016 inductee into its VIP ... this prestigious distinction for leadership in business. NAPW is ... boasting more than 700,000 members and over 200 operating ... this important honor,” said NAPW President Star Jones. “Her ...
(Date:6/1/2015)... Carson Energy also announced they have selected ... AdvantaIRA Trust, LLC is the country’s largest self-directed IRA ... positions using IRA’s does 2 things:, 1. It gives ... if there current cash position will not allow for ... Carson and their investors to be able to participate ...
(Date:6/1/2015)... 2015 The Delta Dental Foundation is ... organizations in Michigan, Ohio and Indiana for its Brighter ... 30, 2015 has been set. , Across the tri-state ... organizations that specifically focus on children’s oral health and ... health in adults. Each grant request will be considered ...
(Date:6/1/2015)... (PRWEB) June 01, 2015 EBSCO ... solutions, today introduced DynaMed Plus™ , a cross-platform ... medical professionals. It provides clinicians with the ideal blend ... patient care paths. , DynaMed Plus is a ... and includes the most frequently updated evidence-based content. DynaMed ...
(Date:6/1/2015)... Orlando, Florida (PRWEB) June 01, 2015 ... have generously donated $88,000 of the best superfood ... of the record-breaking floods in Texas. , "Monica ... Adams and Natural News in distributing Living Fuel Super ... victims of the millennial floods in Texas," KC Craichy ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Inducts Linda Cade, Senior Product Manager at Sage, Into its VIP Professional Woman of the Year Circle 2Health News:Carson Energy Brings Oil Wells To IRAs 2Health News:Brighter Futures Community Grants Program Seeks to Help Fund Local Oral Health Programs 2Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 2Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 3Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 4Health News:Nearly $100,000 In Emergency Food Aid to Flood Victims in Texas Provided by Living Fuel and Natural News 2Health News:Nearly $100,000 In Emergency Food Aid to Flood Victims in Texas Provided by Living Fuel and Natural News 3
... , TUESDAY, Nov. 15 (HealthDay News) -- A novel treatment ... bone health of postmenopausal women who are at high risk ... on a motorized, vibrating platform in the hope of building ... hoped those results might translate to humans, found no benefit ...
... expression test was found to be more effective for ... patients than myocardial perfusion imaging (MPI), a common test ... flow and function of the heart., Study results were ... 2011 conference in Orlando, Fla. , "In this real-world ...
... High school health classes fail to help students refuse ... primarily on testing knowledge, a new study reveals. But ... and to improve health, students had much better responses. In ... sex and felt better able to navigate sexual situations. ...
... , TUESDAY, Nov. 15 (HealthDay News) -- New research suggests ... other people see you at first glance in terms of ... influence your personality, especially in terms of empathy. Or it,s ... way you act. On the other hand, the research is ...
... of problem drinking, a significant decrease in the function of ... is the system that regulates such functions as impulse control ... is seen in men. This is the conclusion of multidisciplinary ... Sahlgrenska Academy at the University of Gothenburg, Sweden. The ...
... TUESDAY, Nov. 15 (HealthDay News) --,Low levels of vitamin D ... stroke, according to one of several new studies on the ... more than 2,000 healthy, postmenopausal white women aged 45 to ... D deficiency had more risk factors for heart disease than ...
Cached Medicine News:Health News:Whole-Body Vibration Doesn't Build Bone After All: Study 2Health News:Blood-based genomic test better than imaging test for ruling out obstructive coronary artery disease 2Health News:Focus on testing hurts students in high school health classes 2Health News:Focus on testing hurts students in high school health classes 3Health News:Does a Gene Make People Seem Kinder? 2Health News:Does a Gene Make People Seem Kinder? 3Health News:Low Vitamin D May Increase Stroke, Heart Attack Risk in Women 2
(Date:6/1/2015)... /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX: PVTTF) (CSE: ... on Omega-3 therapies for cardiovascular disease (CVD) and ... results for the three months ended March 31, ... Canadian dollars unless otherwise stated. "Pivotal ... its limited financial resources," stated Mr. Eugenio ...
(Date:6/1/2015)... June 1, 2015   Regulus Therapeutics Inc ... leading the discovery and development of innovative medicines ... Xanthopoulos , Ph.D. has resigned as President and ... Regulus, Board of Directors, effective today, to pursue ... M.D., who previously served as Chief Medical Officer ...
(Date:6/1/2015)... , June 1, 2015 The nuclear ... by 2020 at a CAGR of 12.08%. Nuclear medicine ... diseases. The two major types of Nuclear imaging used ... was the mainstream modality for nuclear medicine applications like ... to change because of global shortage of molybdenum-99 isotope ...
Breaking Medicine Technology:Pivotal Therapeutics Announces First Quarter Financial Results 2Pivotal Therapeutics Announces First Quarter Financial Results 3Pivotal Therapeutics Announces First Quarter Financial Results 4Pivotal Therapeutics Announces First Quarter Financial Results 5Regulus' Kleanthis G. Xanthopoulos, Ph.D., to Step Down as President and Chief Executive Officer 2Regulus' Kleanthis G. Xanthopoulos, Ph.D., to Step Down as President and Chief Executive Officer 3Regulus' Kleanthis G. Xanthopoulos, Ph.D., to Step Down as President and Chief Executive Officer 4North America Nuclear Imaging Market - Growth, Trends And Forecasts (2014 - 2019) 2North America Nuclear Imaging Market - Growth, Trends And Forecasts (2014 - 2019) 3
... CYBX ) today announced that the company will report financial results ... year ending April 29, 2011 on Monday, November 22, 2010 at ... discuss those results on the same day at 9:00 AM ET ... Call InstructionsTo listen to the conference call live by telephone dial ...
... 2010 PharmAthene, Inc. (NYSE Amex: PIP ) ... threats, today announced that it has closed its previously announced ... at a price to the public of $3.50 per share. ... yield proceeds, before expenses, of approximately $14.1 million and intends ...
Cached Medicine Technology:Cyberonics Announces Conference Call to Discuss Fiscal Year 2011 Second Quarter Financial Results 2PharmAthene Announces Closing of $15 Million Public Offering 2PharmAthene Announces Closing of $15 Million Public Offering 3
The new ProteomeX Workstation enables the rapid set up, execution and analysis of multidimensional LC/MS methods, providing you with the best possible technique to characterize your complex proteomic...
Storage temperature: 2 - 8C, linearity: 0 - 700 mg/dL, expected values: 30 - 780 mg/dL. Available with calibrator and number of tests 110....
Alkaline phosphatase FS (DGKC new; 37C). For determination of alkaline phosphatase (ALP) in serum or plasma. For Hitachi 717. Controls: Trulab N and Trulab P....
For the direct colorimetric determination of alkaline phosphatase in human serum....
Medicine Products: