Navigation Links
Wistar researchers follow a path to a potential therapy for NF2, a rare tumor disorder
Date:4/15/2011

PHILADELPHIA (April 15, 2011) The proteins that provide cells with a sense of personal space could lead to a therapeutic target for Neurofibromatosis Type 2 (NF2), an inherited cancer disorder, according to researchers at The Wistar Institute. Their findings, which appear in the April 12 issue of the journal Cancer Cell, could have profound implications for NF2 and related cancers, such as mesothelioma.

The researchers describe, for the first time, that Merlin, the protein encoded within the NF2 gene interacts with a protein called angiomotin. This connection between Merlin and angiomotin also brings together two important information networks in cells, both of which have been implicated in numerous forms of cancer. It is a connection, the researchers say, between the sensors that detect interactions between cells and the signaling networks that drive cell division.

"Angiomotin is required for movement of cells that form new blood vessels, so it is fascinating to see it so closely linked to merlin, the product of the NF2 gene, loss of which leads to tumor formation," said Joseph Kissil, Ph.D., senior author of the study and associate professor in the Molecular and Cellular Oncogenesis Program of The Wistar Institute Cancer Center. "The discovery opens up a potential new method to treat NF2 by attacking the tumor cells directly and by starvation, a strategy already employed in certain cancer therapies."

"Drugs like Avastin, for example, target the growing blood vessels," Kissil said, "but what makes angiomotin a tempting target is that it is used by both blood vessels and the growing tumor cells that need the nutrients these blood vessels provide."

NF2 is a genetic disorder caused by a mutation in both copies of a person's NF2 gene. It occurs in about one in every 30,000 people, and it is mostly hereditary. NF2 generally appears as benign tumors in the nervous system of young adults, often causing deafness as tumo
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3934
The Wistar Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Wistar researchers discover new class of objects encoded within the genome
2. Wistar scientists explain the persistence of melanoma through dynamic stemness
3. Whales Not Just Singing the Same Old Song, Researchers Say
4. Boston University researchers find most substance-dependent individuals report poor oral health
5. University of Granada researchers make the first bioartificial organ in Spain
6. Queens researchers pioneer needle-free test for premature babies
7. Mechanism for invasion of tumorous cells discovered by Hebrew University researchers
8. Researchers find anatomic differences after robotic-assisted radical prostatectomy
9. Researchers present new findings on cancer and gene therapy
10. Fox Chase researchers find that fish oil boosts responses to breast cancer drug tamoxifen
11. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... August 04, 2015 , ... It is National Psoriasis Awareness ... and its uncomfortable symptoms such as dry, itching, burning or soreness of skin that ... to medication before they find what’s right for them. Then, what is effective may ...
(Date:8/4/2015)... , ... August 04, 2015 , ... Centurion Service Group, ... over 1,000 pieces of used medical equipment. , The live auction will ... sold at their Fort Lauderdale warehouse located at 5025 North Hiatus Road Sunrise, FL ...
(Date:8/4/2015)... York, NY (PRWEB) , ... August 04, 2015 , ... ... all but universal, though the desire for invasive surgery to achieve this ideal is ... offer the results people crave without the high cost or lengthy recovery time, according ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... ... of higher learning, announced today that its RN to BSN and Master ... been awarded full accreditation through June 2020 from the Commission on Collegiate ...
(Date:8/4/2015)... ... 04, 2015 , ... Nathan’s Famous was recently featured on NewsWatch ... large businesses making an impact in their industry. Andrew Tropeano, the host of NewsWatch ... hot dog maker now offers a 50% Reduced Fat All-Beef Frank variety and ...
Breaking Medicine News(10 mins):Health News:USA Medical Card Offers a Solution During National Psoriasis Awareness Month 2Health News:USA Medical Card Offers a Solution During National Psoriasis Awareness Month 3Health News:Medical Equipment Auction to Take Place in Fort Lauderdale 2Health News:Considering fillers, tighteners or laser resurfacing? 2Health News:Considering fillers, tighteners or laser resurfacing? 3Health News:Considering fillers, tighteners or laser resurfacing? 4Health News:Loyola University New Orleans Awarded Accreditation for its Online RN to BSN and MSN Programs 2Health News:Loyola University New Orleans Awarded Accreditation for its Online RN to BSN and MSN Programs 3Health News:Loyola University New Orleans Awarded Accreditation for its Online RN to BSN and MSN Programs 4Health News:Celebrate Summer with Nathan’s Famous Original Selfie Sweepstakes 2Health News:Celebrate Summer with Nathan’s Famous Original Selfie Sweepstakes 3
... ... brand Intellicig has signed an exclusive deal which will see their products stocked in ... and Smiths News. , ... (PRWeb UK) February 2, 2010 -- Leading electronic cigarette brand Intellicig has signed ...
... , INDIANAPOLIS , Feb. 2 ... management is scheduled to present at the UBS 20th Annual Global ... 8:00 a.m. Eastern Standard Time .   , All interested parties ... visiting www.wellpoint.com and selecting the "Investor Info" ...
... cancer may increase a man,s risk of suicide or ... new study published online February 2 in the ... study the risks men diagnosed with prostate cancer in ... Channing Laboratory, Department of Medicine, Brigham and Women,s Hospital, ...
... ... to the Oakland University William Beaumont School of Medicine. , ... (Vocus) February 2, 2010 -- The Liaison Committee ... School of Medicine ., , , , ,The LCME is the national accrediting authority for ...
... study suggests, , TUESDAY, Feb. 2 (HealthDay News) -- ... sudden infant death syndrome (SIDS), new research finds. , Babies ... -- an important regulator of involuntary functions such as breathing ... other causes, the study found. This finding may eventually lead ...
... , , WASHINGTON , Feb. ... granted Wellness & Health Promotion (WHP) Accreditation to Medical Mutual of ... to complete the survey process for NCQA,s new program. , ... the United States to receive NCQA,s WHP Accreditation. , ...
Cached Medicine News:Health News:Intellicig Clinches Exclusive Deal with Retail Distribution-Giant to Distribute Their Industry Leading Electronic Cigarettes 2Health News:Intellicig Clinches Exclusive Deal with Retail Distribution-Giant to Distribute Their Industry Leading Electronic Cigarettes 3Health News:WellPoint Announces Appearance at Upcoming Conference 2Health News:WellPoint Announces Appearance at Upcoming Conference 3Health News:Immediate risk of suicide and cardiovascular death after a prostate cancer diagnosis 2Health News:Oakland University William Beaumont School of Medicine Reaches Development Milestone 2Health News:Serotonin May Be Key to Sudden Infant Deaths 2Health News:Serotonin May Be Key to Sudden Infant Deaths 3Health News:Medical Mutual is the First Ohio Health Plan to Receive NCQA Wellness & Health Accreditation 2
(Date:8/3/2015)... -- Luminex Corporation (NASDAQ: LMNX ) today announced financial ...  Financial and operating highlights for the quarter include the ... by 6 percent to $58.9 million, over the second ... assay revenue by 22 percent to $24.2 million over ... Increased Q2 2015 royalty revenue by 17 percent to ...
(Date:8/3/2015)... Diplomat Pharmacy, Inc. (NYSE: DPLO ), the ... quarter ended June 30, 2015. All comparisons, unless otherwise noted, ... Second Quarter 2015 Highlights include: , Revenue ... , Total prescriptions dispensed of 234,000, an increase of ... , Adjusted EBITDA of $22.7 million, an increase of 287% ...
(Date:8/3/2015)... BUFFALO, N.Y. , Aug. 3, 2015 /PRNewswire/ ... the Wilmot Cancer Institute to the OmniSeq SM ... from Roswell Park Cancer Institute (RPCI) and announced ... products that support a physician-driven, collaborative approach to ... patient outcomes.  Wilmot Cancer Institute is a rapidly ...
Breaking Medicine Technology:Luminex Corporation Reports Record 2nd Quarter 2015 Results 2Luminex Corporation Reports Record 2nd Quarter 2015 Results 3Luminex Corporation Reports Record 2nd Quarter 2015 Results 4Luminex Corporation Reports Record 2nd Quarter 2015 Results 5Luminex Corporation Reports Record 2nd Quarter 2015 Results 6Luminex Corporation Reports Record 2nd Quarter 2015 Results 7Luminex Corporation Reports Record 2nd Quarter 2015 Results 8Luminex Corporation Reports Record 2nd Quarter 2015 Results 9Luminex Corporation Reports Record 2nd Quarter 2015 Results 10Luminex Corporation Reports Record 2nd Quarter 2015 Results 11Luminex Corporation Reports Record 2nd Quarter 2015 Results 12Luminex Corporation Reports Record 2nd Quarter 2015 Results 13Luminex Corporation Reports Record 2nd Quarter 2015 Results 14Luminex Corporation Reports Record 2nd Quarter 2015 Results 15Luminex Corporation Reports Record 2nd Quarter 2015 Results 16Diplomat Announces 2nd Quarter 2015 Financial Results 2Diplomat Announces 2nd Quarter 2015 Financial Results 3Diplomat Announces 2nd Quarter 2015 Financial Results 4Diplomat Announces 2nd Quarter 2015 Financial Results 5Diplomat Announces 2nd Quarter 2015 Financial Results 6Diplomat Announces 2nd Quarter 2015 Financial Results 7Diplomat Announces 2nd Quarter 2015 Financial Results 8Diplomat Announces 2nd Quarter 2015 Financial Results 9Diplomat Announces 2nd Quarter 2015 Financial Results 10Diplomat Announces 2nd Quarter 2015 Financial Results 11Diplomat Announces 2nd Quarter 2015 Financial Results 12Diplomat Announces 2nd Quarter 2015 Financial Results 13Diplomat Announces 2nd Quarter 2015 Financial Results 14Diplomat Announces 2nd Quarter 2015 Financial Results 15Diplomat Announces 2nd Quarter 2015 Financial Results 16Diplomat Announces 2nd Quarter 2015 Financial Results 17Diplomat Announces 2nd Quarter 2015 Financial Results 18OmniSeq Adds Wilmot Cancer Institute to its Collaboration-Based Treatment Network 2OmniSeq Adds Wilmot Cancer Institute to its Collaboration-Based Treatment Network 3
... , MORRISVILLE, N.C., Dec. ... the investigation of devices for minimally-invasive treatment for heart ... trial designed to evaluate the safety and efficacy of ... for the treatment of symptomatic paroxysmal atrial fibrillation (AF). ...
... , ALBUQUERQUE, N.M., Dec. 1 Exagen ... and markets proprietary genomic tests, today announced the appointment ... of directors and chief executive officer. , Prior to ... Partners and founder of a number of successful biomedical ...
Cached Medicine Technology:nContact Announces Initiation of Clinical Trials for the Treatment of Paroxysmal Atrial Fibrillation Utilizing New Convergent Ablation Procedure 2Scott Glenn Joins Exagen Diagnostics as Chairman and CEO 2
Irrigating Cystotome, Straight, 25 g. Overall length 15 mm. 5/box....
Irrigating Capsulorhexis Cystotome. Formed blunt tip, 25 g. Overall length 22 mm. 5/box....
Irrigating Cystotome, formed, 23 g., 12 mm curved tip. Overall length 14 mm. 5/box....
Retrobulbar Needle, 25 g. Atkinson style bevel. Overall length 38 mm. 5/box....
Medicine Products: