Navigation Links
Wistar Institute team finds key target of aging regulator
Date:6/10/2009

Researchers at The Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study, published June 11 in Nature, provides fundamental knowledge about key mechanisms of aging that could point toward new anti-aging strategies and cancer therapies.

Scientists have long known that a class of proteins called sirtuins promotes fitness and longevity in most organisms ranging from single-celled yeast to mammals. At the cellular level, sirtuins protect genome integrity, enhance resistance to adverse stresses, and antagonize senescence. However, the underlying molecular mechanisms have remained poorly understood. The team, led by senior author Shelley Berger, Ph.D., Hilary Koprowski Professor at The Wistar Institute, demonstrated for the first time a molecular target for a member of this class, Sir2, in regulation of aging in yeast cells. Sir2 removes an acetyl group attached to a specific site (lysine at position 16 or K16) on histone H4histones are proteins that package and organize the long strands of DNA within the nucleus and also are central regulators in turning genes on and off. The study reveals that removal of this acetyl group by Sir2 near the chromosome endsthe telomeresis important for yeast cells to maintain the ability to replicate. Researchers found that Sir2 levels decline as cells age, and there is a concomitant accumulation of the acetylation mark along with disrupted histone organization at telomeres.

Deacetylation of H4K16 by Sir2 and consequent telomere stability play a major role in maintaining long lifespan in yeast. Since sirtuins deacetylate many different proteins, these results clarify a key role of Sir2 protein in control of lifespan.

"Some modifications on histones, like this acetylation on histone H4 lysine 16, are persistent and are maintained through generations of cell divisions. This DNA-independent inheritance is called epigenetics," B
'/>"/>

Contact: Susan Finkelstein
sfinkelstein@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Los Angeles Times writer wins Wistar Institute Science Journalism Award
2. The Wistar Institute collaborates with the Coriell Institute to distribute cell lines
3. Novel vaccine concept developed by scientists at the Wistar Institute
4. Cortiva Institute to Open Branch Location in Woodridge, IL
5. Entest BioMedical Inc. Adds Former National Cancer Institute Researcher to Scientific Advisory Board With Focus on Stem Cell Cancer Patient Therapies
6. Senetek PLC Gains Six Year Extension of Rights from Czech Republic Institute of Experimental Botany
7. Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Incs. GCS-100 Molecule
8. Ortho Biotech Oncology Research & Development Announces Collaboration with National Cancer Institute to Develop Novel Cell Therapies to Treat Cancer
9. Z Trim Holdings Abstract Selected as Best of the Best by Institute of Food Technologists
10. Council for American Medical Innovation and The Aspen Institute Bring Leaders Together In Washington, D.C., To Discuss The Economic Impact Of Medical Science and Discovery, and Policies Needed To Maintain U.S. Leadership at Best And Brightest Forum On Me
11. Florida Hospital Cardiovascular Institute Completes House-Wide Implementation of the LifeSync(R) Wireless ECG System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... OH (PRWEB) October 20, 2014 Women’s ... Specialists in Obstetrics & Gynecology of Columbus, Inc., A ... women’s healthcare services to more than 100,000 patients annually. ... though all ages and stages of a women’s life. ... office locations in Westerville and Dublin. , Dr. ...
(Date:10/20/2014)... hc1.com today announced the launch ... that enables healthcare organizations of all sizes to ... relationship management (“CRM”) solution. , Designed from the ... the healthcare industry, the hc1 Healthcare Relationship Cloud™ ... by combining healthcare CRM, HIPAA-compliant collaboration, and real-time ...
(Date:10/20/2014)... CA (PRWEB) October 20, 2014 JZ ... expertise, nutritional coaching, corporate wellness programming, authorship, international lecturing ... is excited to announce the release of the JZ ... After many years of coaching thousands of individuals on ... tracking app that does not require calorie counting or ...
(Date:10/20/2014)... Principle Business Enterprises, a family owned ... top-of-the-line absorbent products. The company has recently made ... brand, Tranquility® Premium Protection absorbent products. The company ... its packaging a new look, and is currently working ... the public. , The new website, developed with Thread ...
(Date:10/20/2014)... 20, 2014 Myoderm ... Assistant Director of their CentralSource service. ... the innovative turnkey drug sourcing, distribution, and management ... over 12 years of industry experience, in both ... the peak of their international success to help ...
Breaking Medicine News(10 mins):Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2
... , , CHICAGO, Sept. ... by House Majority Leader Steny Hoyer (D-MD) - for recognizing the ... the overall health care reform bill currently under consideration. Over ... Democrats and Republicans across the country talking with constituents at town ...
... , , , ... Supermarkets are helping customers stay healthy and well by once ... period will start September 17 and run through November 1 ... doctor-administered vaccines. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20030421/STATERLOGO ...
... , , , JACKSONVILLE, ... taking place Friday, Sept. 11, 2009, Wounded Warrior Project (WWP) and ... revenues generated from global trades made on that day. , , ... was created while Cantor Fitzgerald rebuilt following the World Trade Center attacks ...
... , , FARMINGDALE, N.Y., ... a developer of minimally invasive ultrasonic medical device technology, which ... worldwide for other acute health conditions, today announced the restructuring ... business units have been created; one for sales and service ...
... COLO Research published in the September 2009 issue of ... an individual,s quality of life prior to treatment can help ... cell lung cancer (NSCLC). For those with advanced stage ... months, with approximately one-third of patients surviving past the one ...
... are developing computer models to comb through thousands of ... claims data to automatically classify them based on specific ... the most important causes of injuries so that efforts ... in society," said Mark Lehto, an associate professor in ...
Cached Medicine News:Health News:Statement from the American College of Surgeons Regarding Growing Democrat Support for Medical Liability Reform to be Included in Health Care Reform 2Health News:Stater Bros. Helps Customers Fight the Flu 2Health News:Wounded Warrior Project to Participate in BGC Partners Annual Charity Day 2Health News:Misonix Restructures and Expands Sales Organization in Europe 2Health News:Misonix Restructures and Expands Sales Organization in Europe 3Health News:Misonix Restructures and Expands Sales Organization in Europe 4Health News:New computer models aim to classify, help reduce injury accidents 2
(Date:10/17/2014)... The following is being released by ... The Green Park Collaborative (GPC) will bring together ... medical device and pharmaceutical companies, as well as ... 2015 at its first ever workshop on the ... Participants will discuss study designs to evaluate weight ...
(Date:10/17/2014)... NORWALK, Conn. , Oct. 17, 2014  UBM ... leading online community for endocrinologists and other clinicians who ... offers comprehensive coverage on effective use of insulin ... will eventually require insulin replacement therapy – ... up for the progressive decline in the function of ...
(Date:10/17/2014)... 2014  Ameritox SM , the nation,s leader in ... Thomas Smith , M.D., as Chief Medical Officer. In ... scientific resources for healthcare providers, patients and managed care ... at a variety of healthcare companies that have provided ... and behavioral health sides of Ameritox,s business. He most ...
Breaking Medicine Technology:Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3Ameritox Appoints New Chief Medical Officer 2
... Generex Biotechnology Corporation ( www.generex.com ) (OTCBB: ... President & Chief Executive Officer, and Dr. Eric ... Antigen Express, Inc. ( www.antigenexpress.com ) will make ... 13th Annual Healthcare Conference.  The presentation will take ...
... CITY, Calif., Sept. 7, 2011 Codexis, Inc. ... the company will be participating in the following ... ConferenceDate: Thursday, September 15, 2011 (Company presentation)Time: 8:00 ... of Financial Planning & Analysis A webcast and ...
Cached Medicine Technology:Generex to Present at the Rodman & Renshaw 13th Annual Healthcare Conference 2Generex to Present at the Rodman & Renshaw 13th Annual Healthcare Conference 3
ENA Screen EIA Auto-Immune Markers 012-MDKES1 Extractable Nuclear Antigens...
Anti-PR3 EIA Auto-Immune Markers 013-PR3-48 Proteinase...
... can be viewed immediately, making procedures more efficient. ... the images are digital, they can be used ... electronic filing. The CR-DGi combines the power ... use. It's the latest advance from Canon, the ...
...
Medicine Products: