Navigation Links
Wistar Institute team finds key target of aging regulator
Date:6/10/2009

Researchers at The Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study, published June 11 in Nature, provides fundamental knowledge about key mechanisms of aging that could point toward new anti-aging strategies and cancer therapies.

Scientists have long known that a class of proteins called sirtuins promotes fitness and longevity in most organisms ranging from single-celled yeast to mammals. At the cellular level, sirtuins protect genome integrity, enhance resistance to adverse stresses, and antagonize senescence. However, the underlying molecular mechanisms have remained poorly understood. The team, led by senior author Shelley Berger, Ph.D., Hilary Koprowski Professor at The Wistar Institute, demonstrated for the first time a molecular target for a member of this class, Sir2, in regulation of aging in yeast cells. Sir2 removes an acetyl group attached to a specific site (lysine at position 16 or K16) on histone H4histones are proteins that package and organize the long strands of DNA within the nucleus and also are central regulators in turning genes on and off. The study reveals that removal of this acetyl group by Sir2 near the chromosome endsthe telomeresis important for yeast cells to maintain the ability to replicate. Researchers found that Sir2 levels decline as cells age, and there is a concomitant accumulation of the acetylation mark along with disrupted histone organization at telomeres.

Deacetylation of H4K16 by Sir2 and consequent telomere stability play a major role in maintaining long lifespan in yeast. Since sirtuins deacetylate many different proteins, these results clarify a key role of Sir2 protein in control of lifespan.

"Some modifications on histones, like this acetylation on histone H4 lysine 16, are persistent and are maintained through generations of cell divisions. This DNA-independent inheritance is called epigenetics," B
'/>"/>

Contact: Susan Finkelstein
sfinkelstein@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Los Angeles Times writer wins Wistar Institute Science Journalism Award
2. The Wistar Institute collaborates with the Coriell Institute to distribute cell lines
3. Novel vaccine concept developed by scientists at the Wistar Institute
4. Cortiva Institute to Open Branch Location in Woodridge, IL
5. Entest BioMedical Inc. Adds Former National Cancer Institute Researcher to Scientific Advisory Board With Focus on Stem Cell Cancer Patient Therapies
6. Senetek PLC Gains Six Year Extension of Rights from Czech Republic Institute of Experimental Botany
7. Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Incs. GCS-100 Molecule
8. Ortho Biotech Oncology Research & Development Announces Collaboration with National Cancer Institute to Develop Novel Cell Therapies to Treat Cancer
9. Z Trim Holdings Abstract Selected as Best of the Best by Institute of Food Technologists
10. Council for American Medical Innovation and The Aspen Institute Bring Leaders Together In Washington, D.C., To Discuss The Economic Impact Of Medical Science and Discovery, and Policies Needed To Maintain U.S. Leadership at Best And Brightest Forum On Me
11. Florida Hospital Cardiovascular Institute Completes House-Wide Implementation of the LifeSync(R) Wireless ECG System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... OK (PRWEB) July 31, 2014 Shiitakes ... As in the recipe for Quick-Fix Spaghetti Sauce below, ... second-most consumed mushroom worldwide, valued for their deep flavor ... mushrooms. They absorb flavors of the foods they're cooked ... texture and offer high-protein, low-fat nutrition. Shiitakes are rich ...
(Date:7/31/2014)... San Francsico, CA (PRWEB) July 31, 2014 ... in Sweden have published the largest study ... from triage through either teledermoscopy or traditional letter ... indicate that smartphone referrals via patent pending iDoc24® ... of patients with skin cancer while potentially eliminating ...
(Date:7/31/2014)... -- A class of medications previously linked to ... negatively affect their physical functioning according to investigators ... Center for Aging Research, the University of East ... In a systemic review of more than a ... with anticholinergic properties, they report that these drugs ...
(Date:7/31/2014)... 31, 2014 Controlled application of vacuum pressure is ... brain injury (TBI), suggests an experimental study in the ... journal of the Congress of Neurological Surgeons . ... Wilkins , a part of Wolters Kluwer Health ... applied over the injured area of the brainshows promise ...
(Date:7/31/2014)... July 31, 2014 Rivetz Corp. today ... authentication services to cloud service providers. The combined solution ... protected multi-factor authentication with online systems. , There ... password-based authentication. It is the root cause of the ... around the globe. Instead of solving the problem, service ...
Breaking Medicine News(10 mins):Health News:Quick Fixin’ Summertime Meals with Shiitake Mushrooms -- Bring ‘em Home and Grow Your Own 2Health News:Quick Fixin’ Summertime Meals with Shiitake Mushrooms -- Bring ‘em Home and Grow Your Own 3Health News:Smartphone iDoc 24 Technology Speeds Time to Diagnosis and Treatment for Skin Cancer Patients 2Health News:Smartphone iDoc 24 Technology Speeds Time to Diagnosis and Treatment for Skin Cancer Patients 3Health News:Smartphone iDoc 24 Technology Speeds Time to Diagnosis and Treatment for Skin Cancer Patients 4Health News:Common drugs adversely impair older adults' physical as well as cognitive functioning 2Health News:Vacuum treatment may limit damage after traumatic brain injury 2Health News:Rivetz Partners with LaunchKey to Offer Next Generation Authentication for Accounts Leveraging Trusted Execution Technology. 2Health News:Rivetz Partners with LaunchKey to Offer Next Generation Authentication for Accounts Leveraging Trusted Execution Technology. 3
... to meet with staff and patients and also to view the ... the opportune moment, the Prime Minister was targeted with questions about ... of the health service. ,To the volley of questions, ... will say it's the end of the NHS or, when you ...
... type 1 or juvenile-onset diabetes also works in a rat ... new report from researchers at Washington University School of Medicine ... 2 diabetes in the same way is very significant because ... prevalent than type 1 diabetes," says senior author Marc R. ...
... Rizal and Marikina City as of Thursday. // ... child from Balanga, Bataan were among its victims,According to ... Center the Valenzuela child was at “critical stage 4,” ... treatment Wednesday. ,Lustre stated that he was ...
... diseases that ails many millions of people in parts ... renewed thrust by The Bill & Melinda Gates Foundation, ... million. ,This fund will assist in controlling ... are spread by parasites and worms. These worms are ...
... Fiancée of England star Wayne Rooney, Coleen McLoughlin launched ... her desire to raise awareness of the work hospices ... much-needed funds.// ,Coleen, 20, has personal experience to ... disorder Rett Syndrome and is a regular visitor to ...
... issue of the British Medical Journal, calcium supplements to kids does ... ,According to the research, 90% of the maximum bone mass ... expected that enhancing bone mass at an early age might reduce ... results of 19 studies, on about 2,900 kids and teens aged ...
Cached Medicine News:Health News:Transplant Cures Rats’ Type 2 Diabetes without Need for Immune Suppression Drug 2Health News:Transplant Cures Rats’ Type 2 Diabetes without Need for Immune Suppression Drug 3
(Date:7/31/2014)... , July 31, 2014  Today, Levi ... new extension to its PageCenterX ® content ... is designed to provide downtime reporting capabilities to ... LRS is releasing the product for general availability, ... EMR applications experience outages for a variety of ...
(Date:7/31/2014)... 2014 Orexigen® Therapeutics, Inc. (Nasdaq: ... quarter 2014, on Thursday, August 7, 2014 before markets ... webcast and conference call at 8:00 a.m. Eastern time ... host the call and webcast to discuss financial results ... accessed by calling (800) 708-4540 (domestic) or (847) 619-6397 ...
(Date:7/31/2014)... , July 31 2014  Northsight Capital, Inc. ... has been named Chairman and CEO of the company. ... management, legal matters, business development and investment banking. Mr. ... securities industry.  Before his career on Wall Street, Mr. ... of the U.S, Securities and Exchange Commission in ...
Breaking Medicine Technology:LRS Announces Downtime Reporting Solution for Healthcare 2Orexigen Therapeutics to Host Second Quarter 2014 Financial Results Conference Call and Webcast 2Northsight Capital, Inc. Names Wall Street Veteran John Bluher, Former EVP And General Counsel Of Knight Trading Group, Chairman And CEO. 2
... PALO ALTO, Calif., May 3, 2011 Jazz Pharmaceuticals, Inc. (Nasdaq: ... first quarter of 2011. Total revenues for ... to $35.2 million for the first quarter of 2010.  Total ... GAAP net income for the first quarter of 2011 ...
... 3, 2011 Coast Dental Services, Inc., announced today ... the assets of Dental Technology, Inc. (DTI), doing business ... licensed  health care service plan. DTI and its subsidiaries ... Texas, employing 1,200 staff members, including 130 dentists.  The ...
Cached Medicine Technology:Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 2Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 3Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 4Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 5Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 6Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 7Coast Dental to Acquire the Assets of SmileCare 2
... supply is the latest edition ... offering. It sets new standards ... This product has unique features ... as microAmp detector, display and ...
... as a constant voltage power supply, the 105 ... and hilo range switch control the output, which ... 250 volts. One, two-position switch toggles the bright ... current. The 105 is equipped with an over ...
... power supply is capable of producing up to ... product operates in constant voltage or constant current ... crosses over from one mode of operation to ... A dual function, auto ranging 24-hour ...
... designed for horizontal and vertical gel electrophoresis ... accomplished. In this power supply model, output ... or constant voltage. Four sets of output ... simultaneously. This power supply's light, compact and ...
Medicine Products: