Navigation Links
Window of opportunity to treat some stroke patients may be longer than originally suspected
Date:9/27/2011

Stroke victims may have a longer window of opportunity to receive treatment to save their brain cells, demonstrates a literature review published by University of Alberta medical researchers in Lancet Neurology.

The review, which was published online last week, was written by Ashfaq Shuaib and his colleagues. Shuaib, the senior author, is a researcher in the Division of Neurology with the Faculty of Medicine & Dentistry at the University of Alberta. He is also a practising neurologist and a stroke specialist.

Literature reviews, which bring together large amounts of information from numerous studies, is one form of clinical research often referred to as health-outcomes research. This kind of "translational" work is valuable, since it synthesizes knowledge that lab researchers know and analyzes it for practising physicians so they can provide better patient care. The Faculty of Medicine & Dentistry has special expertise in conducting sophisticated health-outcomes research taking knowledge "from bench to bedside."

Shuaib reviewed stroke studies that examined the use of imaging to measure blood flow in the brain after a stroke. The literature was written from 1980 to July 2011. His review notes that using advanced neuroimaging, such as multi-dimensional brain CT scans and MRIs, can provide physicians important information about blood flow in the brain following a stroke. This information could enable doctors to provide better treatment to prevent brain cells from dying, through the use of techniques to increase blood flow in the brain.

The review noted that the presence of good "collateral" blood flow in the brain can "sustain brain tissue for hours" after major arteries to the brain have been affected by a stroke, and this flow could potentially offset injury to the brain. Enhancing or maintaining strong blood flow is a potential therapeutic treatment for stroke; it is currently under investigation in several stroke centres around the world, he says.

Shuaib's review notes that stroke is the second most common cause of death, with the majority of the 16 million cases happening in developed nations. A lack of blood flow is the primary cause of a stroke. It is typically triggered by a blockage in a brain artery due to arteries thinning from a build-up of plaque, or by a mass from the heart or neck vessels restricting blood flow to the brain.

Normal blood flow in the brain is between 50-60 ml/100g/minute. If someone suffers a stroke and blood flow levels in the brain fall below 10 ml/100g/minute, brain cells die within minutes of the stroke. However, if blood flow in the brain is between 10-20ml/100g/minute, "the neurons cease function but remain structurally intact and are potentially revivable if normal blood flow is restored," Shuaib says in the review.

He further adds that brain cell death after a stroke may not be complete for hours or even days after a stroke, meaning that the window to treat some stroke patients is longer than three hours the standard timeframe that has been referenced in medicine since the 1990s. Shuaib says cell death can be complete within as little as an hour in some people following a stroke, while other patients have viable brain tissue and cells for days or indefinitely after a stroke. And with current imaging technology, physicians can determine whether brain cells are dead or have simply ceased functioning post-stroke.

"What we're recommending is, don't look at the window of time only, look at the important tissue window which may be quite prolonged in many patients," says Shuaib. "Don't just say, 'oh this person had a stroke 4.5 hours ago, end of story.' This person may have very good tissue you could treat."


'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related medicine news :

1. CED Solutions Offers Free 3-Day Technical Windows 7 Certification Course for Unemployed Individuals
2. ORCS Web, Inc Introduces Windows Cloud Server
3. Window World Confirms EPA Certification under New Lead Paint Renovation Law
4. Zen Windows Offers Energy-Efficient Windows With 2010 Tax Credit in Ohio
5. Lupus Awareness Month Kicks Off at Rockefeller Center: EHE International Donates Display Window to S.L.E. Lupus Foundation for May
6. HIPAA HITECH Compliant Mobile Apps Available for Android, Blackberry and Windows Mobile Smartphones
7. Eyes of cattle may become new windows to detect mad cow disease
8. Mayo Clinic Proceedings: Gabapentin opens window of communication
9. A new drug treatment to close the window on colon cancer
10. Eyes of cattle may become new windows to detect mad cow disease
11. Brain imaging provides window into consciousness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Brady ... announced that its B-595 and B-7569 vinyl label materials received ... and warning labels are tested to remain intact and legible, for use on chemical ...
(Date:4/21/2017)... Colo. (PRWEB) , ... April 21, 2017 , ... The ... the Flex House, the next project in the company’s esteemed VISION House demonstration project ... homeowners use exactly the amount of resources they need to live affordably and abundantly ...
(Date:4/21/2017)... ... ... The Hong Kong Polytechnic University (PolyU) launched today the University Research Facility in ... Kong to support teaching, learning and research. It is also the largest research centre ... Kong. , With an area of 620 square metres and more than 50 ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Alive ... people who wish to overcome their mental health struggles. The Alive team uses ... LeBouthillier says: “Our approach in dealing with a mental health struggle is based on ...
(Date:4/21/2017)... ... April 21, 2017 , ... Metrasens ... of International Trade, the UK’s most prestigious award for business success. The ... of total revenues and has grown by a total of 400% over the ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), announces that it ... 2017 at the Sheraton Hotel in Toronto, Ontario ... the Company is scheduled to present on Tuesday, May 2 at ... Chairman of the Board, Tony Holler will also attend ... For more details ...
(Date:4/19/2017)... Global Prostate Cancer Therapeutics Market: Overview ... cancer therapeutics market analyzes the current and future ... prostate cancer, launch of promising emerging therapies, as ... drugs & therapeutic biological products, and high growth ... side effects are some of the drivers expected ...
(Date:4/19/2017)... April 19, 2017  New research provides evidence that an ... according to a study released today that will be presented ... in Boston , April 22 to ... treatment of Parkinson,s disease, the oral drug levodopa has long ... longevity. But as the disease progresses, the effects of the ...
Breaking Medicine Technology: