Navigation Links
Winding back the clock with kidney stem cells
Date:5/16/2011

Stem cell research courts both controversy and support in the community- depending on your viewpoint.

Now, for the first time, scientists at Monash University's Immunology and Stem Cell Laboratories (MISCL) have shown that they can make human stem cells from healthy adult kidneys without working on human embryos, circumventing ethical concerns around this research.

This achievement will allow group leader Associate Professor Sharon Ricardo and her team to model genetic kidney diseases in the laboratory and tease out the mechanisms that control these difficult-to-treat disorders.

"We're taking human kidney cells and winding back the clock to make their early precursors," Associate Professor Ricardo said.

For the challenging project, which was published in the Journal of the American Society of Nephrology, the Monash researchers started with healthy adult kidney cells, which they reprogrammed back to an embryonic-like state, then compared these kidney stem cells with off-the-shelf embryonic stem cells, and showed that both could form different embryonic tissue types, with their genetic features preserved.

"These kidney cells had their slate wiped clean. Now that gives us the opportunity to change that kidney precursor into all kidney cell types," Dr Ricardo said.

In collaboration with Professor Peter Kerr from Monash Medical Centre, the research team has now generated four stem cell lines from patients with polycystic kidney disease and Alport syndrome, two leading genetic kidney disorders.

"As these stem cells can divide indefinitely in a culture dish, we can make a limitless source of patient-specific stem cells, make kidney cysts and screen drugs on those cells," Professor Kerr said.

"Our ultimate goal is to make off-the-shelf mature kidney cells that patients can use for drug testing and disease modelling."

Associate Professor Ricardo, who is approaching pharmaceutical companies to screen drugs on the kidney stem cells, believes that this personalised medicine approach will produce safer medicines in the future.

But in the short-term, the Monash researcher plans to continue work on the kidney stem cells to study how environmental factors influence how kidney cells behave, tests drugs for their ability to reduce kidney cyst formation and cell proliferation, and better understand how genetic kidney disorders develop in the first place.


'/>"/>

Contact: Samantha Blair
media@monash.edu
61-399-034-840
Monash University
Source:Eurekalert

Related medicine news :

1. Eye movements and sight distance reveal how drivers negotiate winding roads
2. Biological clock could be a key to better health, longer life
3. Fish Oil Pills Turn Back The Clock On Aging
4. Excelltech's New iPhone Alarm Clock App Announces Time When Asked
5. Green Light Exposure Can Reset Body Clock
6. Turning back the cellular clock
7. Ticking biological clock increases womens libido, new research shows
8. Temperature rhythms keep body clocks in sync, UT Southwestern researchers find
9. As Clocks Fall Back on Sunday, Think About Better Sleep
10. Bodys Clock Gene May Play Role in Depression
11. Biological clock ticks slower for female birds who choose good mates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Today, the ... , announced that the much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian ... TV Network. , Each week, on his weekly Whole-Food Warrior TV show, Frank Davis ...
(Date:2/5/2016)... ... February 05, 2016 , ... Francisco Canales, MD and ... their Napa Valley office. The technique utilizes the body’s own healing abilities to ... Dr. Furnas, are part of only a select few cosmetic surgeons bringing this ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... exclusively to funding innovative lymphoma research and serving the lymphoma community through a ... to once again host, Swirl, A Wine Tasting Event at the La Gorce ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Regular gym ... find themselves having to wait longer to access the treadmills. It’s a predictable trend. ... resolutions to lose weight and get in shape by joining gyms, starting new walking ...
(Date:2/5/2016)... ... February 05, 2016 , ... At its annual meeting held ... as Chairman of the National Board of Directors. Mr. McDermott succeeds former APDA Chairman, ... stated Leslie A. Chambers , APDA President and CEO. “Pat has tirelessly served ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... York , February 5, 2016 ... Transparency Market Research report states that the global active ... 2014 and is predicted to reach US$185.9 bn by ... of 6.50% from 2014 to 2020. The title of ... Chemical/Biological, Captive/Contract Manufactured, by Geography, and by Therapeutic Area) ...
(Date:2/5/2016)... , Feb. 5, 2016  Henry Schein, Inc. (NASDAQ: ... products and services to office-based dental, animal health and ... an agreement to acquire a majority ownership interest in ... equipment in Brazil . ... Blumenau, Brazil, Dental Cremer is the dental distribution business of ...
(Date:2/4/2016)... DUBLIN, Ohio , Feb. 4, 2016 ... Pricing Program, or those already participating in the program, ... Guidance, often referred to as the , Mega-Guidance , ... the final guidance is published in September 2016. ... 340B Product and Service Marketing , summarizes the Mega-Guidance,s ...
Breaking Medicine Technology: