Navigation Links
Will my breast cancer spread? Discovery may predict probability of metastasis
Date:10/23/2011

SALT LAKE CITYResearchers from Huntsman Cancer Institute (HCI) at the University of Utah have discovered a new way to model human breast cancer that could lead to new tools for predicting which breast cancers will spread and new ways to test drugs that may stop its spread. Their results are published online today in the journal Nature Medicine.

To create this improved model for breast cancer studies, the researchers grafted tumor tissue from consenting breast cancer patients directly into mouse mammary glands, rather than the traditional approach, where the cancer cells are grown, or cultured, in the laboratory. They discovered that the grafts remained virtually identical to the original human breast cancer in structure, genetic makeup and behavior, unlike the methods that rely on cell cultures.

"The most surprising result was that the tumor grafts spread from the original site, or metastasized, just as they did in the human patients," said the study's principal investigator Alana Welm, Ph.D, assistant professor in the Department of Oncological Sciences and an HCI investigator . "For example, grafts of tumor tissue from patients whose cancer had spread to the lung also spread to the lungs of the mice that received them."

Most breast cancer deaths result from the disease spreading to other areas of the body such as the lymphatic system, lungs, liver, bones or brain.

In addition, researchers found that the successful grafts were nearly all from patients who developed the most aggressive forms of breast cancer and ultimately died of their disease.. This result reveals the modeling method's potential as a tool that, soon after a breast cancer diagnosis, could identify whether the tumor would be likely to spread, helping doctors select the best treatment approach for an individual patient's form of the disease.

"There is also the potential to develop similar models for other cancers using this method," says Welm. "We are already working on this with colon cancer tissues."


'/>"/>

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Related medicine news :

1. Femara May Beat Tamoxifen at Preventing Breast Cancers Return
2. Breast Cancer Risk May Rise With High Hormone Levels
3. Elevated hormone levels add up to increased breast cancer risk
4. Breast Radiation After Lumpectomy Saves Lives: Study
5. Most breast cancer patients do not have breast reconstruction surgery
6. Discovery of a cell mechanism that reduces effectiveness of breast cancer treatment
7. Can breastfeeding reduce pain in preterm infants?
8. Breast-Feeding, Vaccinations Lower SIDS Risk, Experts Say
9. Obese women have higher risk of suffering breast cancer
10. Dads, community health care workers roles in supporting low-income moms with breast feeding
11. Genetic Profiling Adds New Dimension to Breast Cancer Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Robins & ... in Durant, Oklahoma, on Feb. 21. , The celebration began with a ribbon ... clinic employees, the construction team and tribal leadership. , Choctaw Nation Durant ...
(Date:2/21/2017)... ... ... Individuals who have been diagnosed with cancer are at ... management. Regular exercise in proper environments has been shown to benefit these patients, ... 23, 2017, 1:00-2:00 p.m. E.S.T., a dynamic HydroWorx webinar led by ...
(Date:2/21/2017)... ... February 21, 2017 , ... Each ... Black History Month (officially African American History Month ). This ... society of a diverse race of people, but also the opportunity to examine ...
(Date:2/21/2017)... ... February 21, 2017 , ... CLICKco LLC, a company dedicated ... are now available for purchase on RonnieColemanNutrition.com, a popular website for health and ... health-conscious consumers who love coffee but are looking to add more protein to ...
(Date:2/20/2017)... Raton, FL (PRWEB) , ... February 20, 2017 ... ... creating a patent-pending probiotic supplement that supports the proper levels of “good” bacteria ... purchase on StackedNutrition.com, a popular nutritional products website. , Daily Body Restore® ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... 21, 2017 Cognitive Computing for Cancer ... allowing a previously unattainable level of personalized treatment ... ability, it is anticipated that the Global Cancer ... by 2022. The growth of the market is ... platforms, rising installation of cognitive computing software in ...
(Date:2/21/2017)... 2017 Sangamo Therapeutics, Inc. (Nasdaq: SGMO), the ... company will release its fourth quarter and full year ... February 28, 2017. The press release will be followed ... will be open to the public via telephone and ... its financial results and provide a business update. ...
(Date:2/21/2017)... Feb. 21, 2017  International Isotopes Inc. (OTCQB: INIS) ... placement with certain investors for approximately $3.4 million of ... Series C Convertible Redeemable Preferred Stock (the "Series C ... annual rate of 6% and is convertible into common ... use the proceeds for operating capital, to pay off ...
Breaking Medicine Technology: