Navigation Links
Will lung cancer recur? A genetic test may provide the answer
Date:5/19/2008

ATS 2008, TORONTOThe goal of developing reliable genetic tests to guide lung cancer treatment has taken a step forward. Researchers at Columbia University recently evaluated the ability of five high-risk genetic profiles, or signatures, to predict the likelihood that cancer would recur in patients whose non-small cell lung cancer was caught early and surgically removed. They will present their findings at the American Thoracic Societys 2008 International Conference in Toronto on Tuesday, May 20.

Non-small cell lung cancer, which accounts for about 80 percent of all lung cancers, has a high rate of recurrence even when treated early, said lead researcher William Bulman, M.D. If we knew specifically in which patients the cancer was likely to come back, we could recommend more aggressive therapy to those patients. Dr. Bulman noted that genetic signatures for breast cancer are already commercially available and are used by physicians to guide treatment recommendations.

Dr. Bulman and his colleagues, Drs. Charles Powell and Alain Borczuk, tested five survival gene signatures in 21 patients, with squamous or adenocarinoma tumors who were followed for up to two years after their surgery. The accuracy of the tested signatures ranged from 40 to 80 percent and varied with the type of tumor. A 42-gene signature, for instance, was 82 percent accurate in predicting survival with lung adenocarcinoma, but only 70 percent accurate in predicting survival with squamous cell carcinoma.

Lung cancer is a heterogeneous disease, and information captured in these tests helps to distinguish tumors in terms of clinical outcomes. explained Dr. Bulman. Our findings not only indicate that genetic signatures have clinical utility in personalizing the treatment of lung cancer, but also that it may be necessary to use different gene-based risk predictors with different tumor subtypes.

Dr. Bulman noted that this research is part of a larger effort to understand the biological basis for why some early stage lung cancers progress and metastasize and why some do not. He added that he and his colleagues are planning to test these genetic signatures in new cohorts of patients for the purposes of targeting patients at high risk for recurrence.


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Blood test for lung cancer may be possible
2. Petition Seeking a Cancer Warning on Cosmetic Talc Powder Products
3. Protein Helps ID Thyroid Cancer Nodules
4. Kidney Cancers More Likely to Be Diagnosed Early
5. Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
6. Majority of kidney cancers diagnosed at earliest stage
7. New data show benefit of finasteride in preventing prostate cancer
8. Cellvizio(R) Confocal Microscopy Improves ERCP Bile Duct Cancer Detection, According to New Study Presented at DDW
9. Prostate Cancer Vaccine Looks Promising in Early Trial
10. Outcomes Similar for Laparoscopic, Open Colon Cancer Surgeries
11. M. D. Anderson nurse addresses lymphedema in breast cancer patients and survivors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... Pro3rd Grunge is a package of ... lower thirds to introduce people, characters, and locations without having to set a single ... textures and many more design components. Simply select a preset and drag it into ...
(Date:4/29/2016)... ... April 29, 2016 , ... The number of chronically and seriously ill individuals ... there is an urgent need for highly skilled care managers and care coordinators. ... approach to train and retain care managers, and enhance their skills. , ...
(Date:4/29/2016)... ... 2016 , ... Orthodontics Limited, one of the nation’s top ... Middleberg, were asked by Invisalign to present an “Ask the Expert” ... “Advancing the Biomechanics of Invisalign Clear Aligners,” Dr. Gemmi and Dr. Middleberg demonstrated ...
(Date:4/28/2016)... ... ... Beauty® is offering a special deal on its webstore. , Buy 1 product and get ... the product with lesser value. In addition, a free bonus of 3 top serums ... , "So many women (men, too) love our products and get good results. We want ...
(Date:4/28/2016)... ... April 28, 2016 , ... Sanford Health’s work in cellular ... of researchers and leaders from Sanford Health were selected to participate in the ... Impact ” and receive the 2016 Pontifical Key Innovation Award at the Vatican. ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 2016 Global  urinalysis market ... by 2022, according to a new report by ... http://photos.prnewswire.com/prnh/20150105/723757 ) , Automation ... and accuracy delivered by the new generation urinalysis ... urinalysis instruments and consumables. For instance, the automatic ...
(Date:4/26/2016)... Diplomat Pharmacy, Inc. (NYSE: DPLO) is pleased ... Pharm D., to Vice President of Education and Quality. ... will continue to lead and oversee Diplomat University, an ... and training to Diplomat employees and external professionals on ... also houses the quality assurance department, which focuses on ...
(Date:4/26/2016)... -- Research and Markets has announced the ... report to their offering.      (Logo: ... market is projected to grow at a CAGR of ... is a technique that involves measurement and analysis of ... changes in biochemical pathways. The aim of performing these ...
Breaking Medicine Technology: