Navigation Links
Will extra protein and exercise help dialysis patients? U of I profs get $2.1 million to find out
Date:9/1/2010

URBANA - University of Illinois scientists will learn whether protein supplements and cycling during treatments can help dialysis patients fight cardiovascular disease and retain physical function, thanks to a $2.1 million grant from the National Institutes of Health (NIH).

"Patients with kidney failure face many health problems. They are at high risk for the more common forms of heart disease, and they also develop a peculiar condition called vascular calcification that makes their arteries stiff," said Ken Wilund, a faculty member in the U of I's Department of Kinesiology and Community Health and Division of Nutritional Sciences, and the study's principal investigator.

Vascular calcification interferes with constriction and dilation of the arteries, which can affect patients blood pressure and have other negative consequences, he said.

Many dialysis patients are also anemic; suffer from a loss in muscle tissue and declines in physical function; and have weak bones due to their abnormal mineral metabolism.

And, when they are being dialyzed, patients lose amino acids across the dialysis membrane. Adding protein to patients diets has long been recommended, but no long-term studies have actually administered protein supplements and reported on their effectiveness, he said.

"Chronic inflammation, loss of amino acids during dialysis, and the often sedentary lifestyle of dialysis patients combine to cause them to lose muscle. In the first year of dialysis, patients with diabetes typically lose 5-1/2 pounds of muscle, and persons who don't have diabetes can expect to lose 2-1/2 pounds of lean tissue.

"They're in a catabolic state--their muscle and skeletal tissue are breaking down," he noted.

Receiving dialysis for three to four hours a day three days a week takes an emotional and financial toll on patients too. "Many of those affected are hurting economically. They feel horrible, may have to travel some distance to a dialysis clinic--perhaps by bus, and are often unable to hold down a job because of their condition. Any improvement in their physical function would be such a plus for them, he said.

The five-year study will take place at two dialysis clinics in Chicago and one clinic in Champaign. Approximately 30 patients will complete a one-year diet and exercise intervention annually, for a total of 150 patients in a five-year period. The scientist hopes to have the study up and running this fall.

How do Wilund and his co-investigators hope to improve their patients' health and quality of life? They'll replace the amino acids dialysis patients are losing by making sure they consume added protein, and introduce them to what the researchers call intradialytic cyclingwe'll put a cycle in front of their chair and encourage them to exercise while they're on dialysis."

Wilund has seen cycling while dialyzing attempted in other clinics and wasn't very impressed, but he believes he has a way around what he perceives as the problem. He said nurses are too busy to supervise the patients' cycling and make sure that the pace of their exercise exceeds that of "a Sunday stroll in the park."

In the new study, students will be involved with the patients one-on-one to motivate them "so they're really moving and strengthening those muscles. Dialysis takes three to four hours, so this is a unique opportunity to help this population become more active," he said.

Wilund and his colleagues hope to answer some very basic questions: What effects do protein supplementation and simple exercise have on heart disease, physical function, retention of muscle tissue, and bone strength in dialysis patients? And, when patients who are in a catabolic state expend more energy, will the breakdown of muscle tissue be arrested or exacerbated? The researchers will be assessing patients at the beginning of the study and again at 6 months and 12 months to find out.

"We think we'll see benefits because we hear anecdotes about dialysis patients who have begun to exercise and are able to walk into the clinic for the first time in years instead of arriving in a wheelchair, or patients who, after beginning an exercise program, are able to go upstairs and clean the second floor of their house after having not been able to do that," he said.

To date, no long-term trials have been conducted that would confirm that anecdotal evidence, he said.


'/>"/>

Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Related medicine news :

1. Cashew seed extract an effective anti-diabetic
2. Getting extra sleep improves the athletic performance of collegiate football players
3. Moms Extra Pregnancy Pounds May Raise Childs Heart Risks
4. Human Extracellular Matrix Significantly Improves Device Biocompatibility
5. Abbey Color Inc. and Mexicana de Extractos International, S.A. de C.V. Announce Joint Venture Abbymex
6. Tahitian Noni Extra Sales Exceed Expectations
7. Sunwin International & WILD Flavors Receive GRAS Letters of No Objection from FDA Validating Safety of Multiple Sunwin Stevia Extracts
8. Tahitian Noni Extra Released With 16 Different Iridoids
9. Green Tea Extract May Delay or Prevent Alzheimers
10. Unique Equipment, Fun Workouts, Extraordinary Results
11. Less Is More with the Innovation of Avemar(R) Fermented Wheat Germ Extract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... ambulance transport experience for the millions of people who require these medical transport ... taxi industry through the use of technology. Now, SmartEMS has put forth an ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... PUNE, India , June 24, 2016 ... "Pen Needles Market by Type (Standard Pen Needles, Safety ... 12mm), Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase ... published by MarketsandMarkets, This report studies the market for ... is expected to reach USD 2.81 Billion by 2021 ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
Breaking Medicine Technology: