Navigation Links
Why tumors become resistant to chemotherapy?
Date:12/2/2013

A common observation in oncology is the phenomenon that a patient with a tumor receives a drug and responds very well, but after a few months the cancer comes back and is now resistant to previously administered chemotherapy. What happened? Many mechanisms contribute to explain this effect called "acquired resistance", but today the group Manel Esteller, Director of Epigenetics and Cancer Biology at the Bellvitge Biomedical Research Institute (IDIBELL) , ICREA researcher and Professor of Genetics at the University of Barcelona, describes in the official Journal of the National Cancer Research Center in the United States , The Journal of The National Cancer Institute, the existence of epigenetic differences that explain the lack of response of the tumor recurs.

"We studied colon cancer cells that were initially sensitive to oxaliplatin drug and then became insensitive to this drug and we found that resistant tumors had inactivated a gene (SRBC) in their DNA" says Manel Esteller "the loss of activity supposedly happens in a gene involved in DNA repair. Thus these tumor cells, when receiving the drug, quickly repair the effect thereof and do not die. Studying nearly two hundred patients with colon cancer also found that inactivation of the gene is associated with poorer survival of these people despite treatment. Interestingly the loss of function of this gene could also explain why some colon tumors are resistant from the outset, what is known as "primary resistance " concludes Esteller.

The discovery could have important implications for personalized treatment of colon cancer. If these findings extend to other clinical trials, determining the activation state of the SRBC gene could be useful in deciding whether a patient should receive a type of drug or another. Likewise the use of another class of drugs that return gen activity (epigenetic drugs) could restore the sensitivity to the original drug , oxaliplatin .

Finally, a very promising door is opened to examine whether similar mechanisms are happening in other human tumors beyond colon cancer.


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert  

Related medicine news :

1. New immunotherapy for malignant brain tumors
2. Biomaterial-delivered chemotherapy could provide final blow to brain tumors
3. Oxygen levels in tumors affect response to treatment
4. Special camera detects tumors
5. Cell Phone Radiation Lawsuit Update: Bernstein Liebhard LLP Comments on Latest Research into Cell Phone Use and Brain Tumors
6. APAC Solid Tumors Market to Grow at a CAGR of 12.3% to 2019 in New Research Report at RnRMarketResearch.com
7. Join the Fight Against Brain Tumors & Get Healthy at the Brain Tumor Run for Research 5k on October 19th
8. New system uses nanodiamonds to deliver chemotherapy drugs directly to brain tumors
9. Bone growth factor may increase benign tumors but not malignant cancer
10. New Way to Track Stem Cell Migration Could Advance Treatments for Brain Tumors and More
11. Voices Against Brain Cancer Comments on New Technique Being Used by Surgeons that Lights Up Brain Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why tumors become resistant to chemotherapy?
(Date:1/20/2017)... ... ... Pastor and Overseer at The House of Yahweh has posted a new publication this week ... is a time like no other and society needs to understand the only way to ... not want to sound like an old bible beater because religion has a bad rap ...
(Date:1/20/2017)... ... 2017 , ... Bionic Sports Nutrition LLC, an American company devoted to developing ... successful January ECRM Trade Show in Hilton Head, SC. , Bionic Sports Nutrition ... provide its products to all clients at reasonable prices. At the ECRM trade show, ...
(Date:1/20/2017)... ... 2017 , ... International Protein, a company based out of Australia that focuses ... January ECRM trade show in Hilton Head, SC. , International Protein was founded ... a line of products that would elevate her fitness regime. At this ECRM trade ...
(Date:1/20/2017)... ... January 20, 2017 , ... Vitamin ... alternative VW+ 002. The drinks have been produced in collaboration with Zlatan Ibrahimovic ... during your workout. , After a successful launch in Sweden last year, the ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a ... Biscuit” is the creation of published author, Marlyn Ivey, born in Lynn Haven, Florida and ... to school and at 19 years of age, he joined the Navy and got married ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017  Stealth BioTherapeutics Inc. ( Stealth ), a ... today announced new additions to its senior leadership team: ... Officer, and Daniel Geffken as interim Chief ... Carr , Pharm.D. has been promoted to Chief Clinical ... welcome Doug and Daniel to our management team, as ...
(Date:1/19/2017)... January 19, 2017 ... Oncology & Haematology, 2016;12(Suppl 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ... ... Published recently in a supplement to ... from touchONCOLOGY, an article by James Gilbart ...
(Date:1/19/2017)... 2017 Pfizer joins Astex, ... Therapeutics Consortium   Major research investment ...   The Milner Therapeutics Institute ... as a partner to the Milner Therapeutics Consortium. Pfizer ... efficient transfer of materials between industry and academia and ...
Breaking Medicine Technology: