Navigation Links
Why 'thick' blood protects from a heart attack
Date:8/24/2009

"Thick" blood can cause heart attack and stroke, but also prevent them. Scientists at Heidelberg University Hospital have explained the mechanism of this clinical paradox for the first time on an animal model. Mice with a greater tendency to form blood clots have larger plaques in their vessels, but they are more stable. Thus, there is less risk that these plaques will rupture and obstruct circulation. The results of the study have been published in the prestigious journal Circulation.

In principle, the more blood coagulates, the greater is the risk of vascular obstruction. Anticoagulants protect against these complications. But clinical studies have thus far not proven that an increased clotting tendency also has a detrimental effect for plaque development. Dr. Berend Isermann, consultant at Heidelberg University Hospital, Department of Internal Medicine I and Clinical Chemistry (Medical Director: Professor Dr. Peter Nawroth), and his team have now found an explanation for this.

Study on an animal model: larger but more stable plaques

The researchers examined mice with elevated blood fat levels and a genetic defect that leads to an increase in blood clotting. The mice developed larger plaques than those without the genetic defect, but the plaques were more stable. In addition, no vascular obstruction was observed, as the vascular wall expanded to adapt to the new situation. The negative effect of larger plaques on circulation was compensated by the positive effect of stability and a greater vessel diameter.

However, the long-term use of anticoagulants (in this case, low molecular weight heparin) reversed these advantages. The size of the plaques was reduced, but stability was lost, increasing the risk of complications.

Caution advised when prescribing anticoagulants

"Our findings were made on mice, but they confirm the results of clinical studies on humans," says Dr. Isermann. "In addition, in vitro studies show that human cells react similarly to mouse cells." The team assumes that the results can be transferred to humans and recommends weighing the advantages and disadvantages of anticoagulants carefully before administering them to a patient. "Currently," continues Dr. Isermann, "there is no indication that these new observations also apply to drugs that inhibit the function of platelets."

When deciding on therapy, the cause of the coagulation disorder and the degree of already existing atherosclerosis should be taken into consideration. Additionally, they recommend using anticoagulants that inhibit specific coagulation factors in order to preserve the positive effects on plaque stability. Various new drugs that inhibit specific coagulation factors are currently being studied in clinical trials. "It is important," says Dr. Isermann, "that plaque stability and the influence on atherogenesis are also studied in these trials."


'/>"/>

Contact: Dr. Berend Isermann
Berend.Isermann@med.uni-heidelberg.de
49-62-215-638-608
University Hospital Heidelberg
Source:Eurekalert  

Related medicine news :

1. Increased distance to physician associated with thicker skin cancer at diagnosis
2. Migraine Tied to Thickening in Brain Area
3. Thickness, Location Predict Skin Cancers Spread
4. Dr. Lark Creates Nutritional Supplement to Restore Thick Hair and Strong Nails
5. Make Lashes Longer, Thicker, and Darker with Latisse™
6. K-State engineers create DNA sensors that could identify cancer using material only one atom thick
7. Hypertension, diabetes and increased carotid artery wall thickness means increased risk of stroke
8. Specific antagonism lowers blood pressure
9. Restricting Blood Flow May Help Heart Bypass Patients
10. FDA Updates Prescription Guidelines for Blood Thinner
11. Doctors Often Miss High Blood Pressure in Kids
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why 'thick' blood protects from a heart attack
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... ... ... a legally blind and certified personal trainer is helping to develop a weight loss fitness ... to fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: