Navigation Links
Why some prostate cancer returns
Date:5/27/2009

ORLANDO The majority of men who receive one of the standard treatments for localized prostate cancer surgery or radiation therapy have an excellent outcome.

But for the small group whose prostate cancer returns, a new study offers insight as to why treatment isn't effective.

The study a collaboration between researchers at the Josephine Ford Cancer Center at Henry Ford Hospital and Fox Chase Cancer Center shows that men with a low oxygen supply to their tumor have a higher chance of the prostate cancer returning, as found by increasing prostate-specific antigen (PSA) levels following treatment.

"After several years of research, we were able to show that low levels of oxygen to the tumor are highly related to a patient's outcome. Those with lower oxygen levels to the prostate cancer did not respond as well to radiation therapy, and the cancer returned more often," says Benjamin Movsas, M.D., senior study author and chair of the Department of Radiation Oncology at Henry Ford Hospital. Moreover, recent studies suggest the same finding also appears to apply to patients treated with surgery.

Results from the study will be presented May 31 at the American Society of Clinical Oncology (ASCO) annual meeting in Orlando.

Prostate cancer affects one in six men in the United States, but according to the American Cancer Society only one in 35 will die of it. The majority of all prostate cancer are diagnosed in men older than 65.

According to Dr. Movsas, oxygen being delivered to a tumor is critical to the treatment for many cancers. Radiation therapy, for example, creates free radicals that damage DNA in tumors, and oxygen acts as the mediator that perpetuates the free radicals.

That's why Dr. Movsas began his work nearly a decade ago to investigate low oxygen levels also known as tumor hypoxia in prostate cancer tumors while working at Fox Chase.

To measure the amount of oxygen being delivered to the tumors and surrounding areas, Dr. Movsas and his colleagues at Fox Chase used custom-made oxygen probes to test 57 patients with low or immediate risk of cancer prior to radiation therapy. The probe was used prior to "radioactive seeds" which were implanted in the prostate.

Dr. Movsas' initial research found that it is possible for prostate cancer tumors to have low oxygen levels. The next step was for the team to track the long-term correlation between low oxygen levels and PSA levels following treatment.

These new findings, being presented at ASCO, ultimately reveal that a tumor's oxygen supply can significantly predict a patient's outcome following treatment, independent from tumor stage or Gleason score, a classification of the grade of prostate cancer. Of the 57 patients, the study found that eight experienced an increase in their PSA levels about eight years following treatment.

"By identifying patients at risk with low oxygen levels in prostate tumors, we're now able to build on this research and begin to explore novel treatment options for this small subset of patients. It's possible we'll find that these patients will do best with a combination of radiation therapy and other novel approaches, such as angiogenesis therapy (targeting blood vessels) or possibly even gene therapy. That's where our research is taking us next," says Dr. Movsas. "Non-invasive methods to detect oxygen levels in tumors are also very important."


'/>"/>

Contact: Krista Hopson
khopson1@hfhs.org
313-874-7207
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Enlarged Prostate and Erectile Dysfunction Are Subjects of Free Mens Health Seminar
2. Predicting higher risk for prostate cancer diagnosis
3. Carbohydrate restriction may slow prostate tumor growth
4. Advanced Prostate Cancer Deadlier in Younger Men
5. Younger men with advanced prostate cancer have shorter survival times
6. Medivation Announces Upcoming Presentation of New MDV3100 Data in Patients With Advanced Prostate Cancer at 45th American Society of Clinical Oncology Annual Meeting
7. Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment
8. Research reveals molecular pathway behind invasive prostate cancers
9. An Aid to Tailoring Prostate Cancer Treatment
10. Long-term study shows low oxygen levels in prostate tumors can predict recurrence
11. Genetic marker may predict early onset of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a ... of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners ... October 11, 2017. , The annual award competition recognizes editorial and design excellence across ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
(Date:10/4/2017)... , Oct. 4, 2017 OBP ... self-contained, illuminating medical devices, today announced regulatory approval ... Surveillance Agency (or Agência Nacional de Vigilância Sanitária ... single-use, cordless surgical retractor with integrated LED light ... access, illumination and exposure of a tissue pocket ...
(Date:10/2/2017)...  AllianceRx Walgreens Prime, the combined central specialty pharmacy ... benefit manager Prime Therapeutics LLC (Prime), today officially began ... unveiling of new signage at its headquarters in ... a few other company-owned facilities across the country. This ... of whom will begin to see the AllianceRx Walgreens ...
Breaking Medicine Technology: