Navigation Links
Why some prostate cancer returns
Date:5/27/2009

ORLANDO The majority of men who receive one of the standard treatments for localized prostate cancer surgery or radiation therapy have an excellent outcome.

But for the small group whose prostate cancer returns, a new study offers insight as to why treatment isn't effective.

The study a collaboration between researchers at the Josephine Ford Cancer Center at Henry Ford Hospital and Fox Chase Cancer Center shows that men with a low oxygen supply to their tumor have a higher chance of the prostate cancer returning, as found by increasing prostate-specific antigen (PSA) levels following treatment.

"After several years of research, we were able to show that low levels of oxygen to the tumor are highly related to a patient's outcome. Those with lower oxygen levels to the prostate cancer did not respond as well to radiation therapy, and the cancer returned more often," says Benjamin Movsas, M.D., senior study author and chair of the Department of Radiation Oncology at Henry Ford Hospital. Moreover, recent studies suggest the same finding also appears to apply to patients treated with surgery.

Results from the study will be presented May 31 at the American Society of Clinical Oncology (ASCO) annual meeting in Orlando.

Prostate cancer affects one in six men in the United States, but according to the American Cancer Society only one in 35 will die of it. The majority of all prostate cancer are diagnosed in men older than 65.

According to Dr. Movsas, oxygen being delivered to a tumor is critical to the treatment for many cancers. Radiation therapy, for example, creates free radicals that damage DNA in tumors, and oxygen acts as the mediator that perpetuates the free radicals.

That's why Dr. Movsas began his work nearly a decade ago to investigate low oxygen levels also known as tumor hypoxia in prostate cancer tumors while working at Fox Chase.

To measure the amount of oxygen being delivered to the tumors and surrounding areas, Dr. Movsas and his colleagues at Fox Chase used custom-made oxygen probes to test 57 patients with low or immediate risk of cancer prior to radiation therapy. The probe was used prior to "radioactive seeds" which were implanted in the prostate.

Dr. Movsas' initial research found that it is possible for prostate cancer tumors to have low oxygen levels. The next step was for the team to track the long-term correlation between low oxygen levels and PSA levels following treatment.

These new findings, being presented at ASCO, ultimately reveal that a tumor's oxygen supply can significantly predict a patient's outcome following treatment, independent from tumor stage or Gleason score, a classification of the grade of prostate cancer. Of the 57 patients, the study found that eight experienced an increase in their PSA levels about eight years following treatment.

"By identifying patients at risk with low oxygen levels in prostate tumors, we're now able to build on this research and begin to explore novel treatment options for this small subset of patients. It's possible we'll find that these patients will do best with a combination of radiation therapy and other novel approaches, such as angiogenesis therapy (targeting blood vessels) or possibly even gene therapy. That's where our research is taking us next," says Dr. Movsas. "Non-invasive methods to detect oxygen levels in tumors are also very important."


'/>"/>

Contact: Krista Hopson
khopson1@hfhs.org
313-874-7207
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Enlarged Prostate and Erectile Dysfunction Are Subjects of Free Mens Health Seminar
2. Predicting higher risk for prostate cancer diagnosis
3. Carbohydrate restriction may slow prostate tumor growth
4. Advanced Prostate Cancer Deadlier in Younger Men
5. Younger men with advanced prostate cancer have shorter survival times
6. Medivation Announces Upcoming Presentation of New MDV3100 Data in Patients With Advanced Prostate Cancer at 45th American Society of Clinical Oncology Annual Meeting
7. Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment
8. Research reveals molecular pathway behind invasive prostate cancers
9. An Aid to Tailoring Prostate Cancer Treatment
10. Long-term study shows low oxygen levels in prostate tumors can predict recurrence
11. Genetic marker may predict early onset of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... 2016 , ... Levels of a protein in the blood associated with heart ... in the journal Radiology. , Heart disease and brain disease exact a major burden ... aging population. Damage to both organs often occurs at a subclinical stage, or before ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... ... high performance connectors, is now promoting to the US market its advanced highly ... ODU LAMTAC® and ODU TURNTAC®. These advanced technologies are ideal for a ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... planning services to families and business owners in the greater Dallas metropolitan area, ... the Dallas Fallen Officer Foundation. , Established in 2009 by active police professionals ...
(Date:12/7/2016)... ... 07, 2016 , ... A. Kevin Spann Insurance, a New York-based firm offering ... is launching a charity drive to raise funds that will benefit the Marine Corps ... marines and Navy FMF Corpsmen. Working closely with the MCL, the A. Kevin Spann ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... that its fully redesigned website, which launched October 17, 2016, features comprehensive information ... design and easy-to-navigate layout. Visitors and patients can discover the latest clinical dermatology ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... SAN DIEGO , Dec. 7, 2016   ... today announced that it has completed enrollment in the ... IP receptor agonist targeting the prostacyclin pathway for the ... approximately 60 patients at sites globally. "This ... and is evidence of our strategic focus on our ...
(Date:12/7/2016)... Dec. 7, 2016 Diplomat Pharmacy, Inc. (NYSE: DPLO) has ... Homecare Federation, At-Home IV Infusion Professional, BioRx, MedPro Rx, and XAS ... services, visit diplomat.is/specialty-infusion .  ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ... "As we continue to build on the ...
(Date:12/7/2016)... Kan. , Dec. 7, 2016   Rx Savings ... West Virginia and its Public Employees Insurance Agency ... members access to their innovative healthcare software, ultimately saving money ... with PEIA and provide its members with access to our ... or a more effective, affordable therapy can be found," says ...
Breaking Medicine Technology: