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Why some depressed girls can't smell the roses
Date:1/3/2008

Cant smell the roses? Maybe youre depressed. Smell too much like a rose yourself? Maybe youve got the same problem. Scientists from Tel Aviv University recently linked depression to a biological mechanism that affects the olfactory glands. It might explain why some women, without realizing it, wear too much perfume.

Scientific research that supports this theory was published this year in the journal Arthritis and Rheumatism. Our scientific findings suggest that women who are depressed are also losing their sense of smell, and may overcompensate by using more perfume, explains researcher Prof. Yehuda Shoenfeld, a member of the Sackler Faculty of Medicine at Tel Aviv University. We also believe that depression has biological roots and may be an immune system response to certain physiological cues.

Women who are depressed are also more likely to lose weight. With a reduced sense of smell, they are less likely to have a healthy appetite, he says.

Prof. Shoenfeld draws his conclusions from lifetime research on autoimmune diseases, focusing on conditions such as lupus, arthritis and rheumatism.

More Than a Feeling

Affecting about 1.5 million Americans, depression accompanying lupus, Prof. Shoenfeld has found, is much more than an emotional reaction to being ill. It appears to have a biological cause.

In lupus patients and those with other autoimmune diseases, a particle known as an autoantibody attacks the persons own immune system, appearing in the human body as an aberrant reaction to autoimmune diseases. This particle is a real novelty, says Prof. Shoenfeld. We have found that, when generated, it weakens a persons sense of smell and can induce the feeling of depression.

Scientists today widely accept the fact that people with Alzheimers disease lose their sense of smell. Prof. Shoenfelds research is the first that links depression to smell in lupus patients, however.

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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

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