Navigation Links
Why so many antibodies fail to protect against HIV infection
Date:11/18/2010

DURHAM, NC Researchers have been stymied for years over the fact that people infected with the AIDS virus do indeed produce antibodies in response to the pathogen antibodies that turn out to be ineffective in blocking infection. Now, scientists at Duke University Medical Center can explain why: Some of the earliest and most abundant antibodies available to fight HIV can't actually "see" the virus until after it's already invaded a healthy cell.

The scientists based their conclusion on the results of a series of crystallography and biochemical experiments that revealed the specific molecular structures different types of antibodies need to have in place in order for them to mount an effective defense.

Previous research had shown that two of the most robust antibodies against HIV antibodies called 2F5 and 4E10 target a specific part of the outer coating of the virus called the MPER region of gp41. The antibodies, which operate in a lock and key relationship, are able to latch on to the virus as it reveals this vulnerable part of its structure, referred to as an "Achilles heel" of the AIDS virus.

"What our studies revealed, however, is that the virus actually creates two versions of this 'Achilles heel,' says Barton Haynes, MD, director of the Duke Human Vaccine Institute (DHVI) and the senior author of the study appearing online in Nature Structural & Molecular Biology. "One version is for these rarer, broadly-neutralizing antibodies, and the other is for the more abundant, first-responding antibodies that won't be able to do much good because the Achilles heel isn't detectable to them until the virus has already gained entry."

Nathan Nicely, PhD, the lead author of the study and a member of the DHVI, designed and conducted most of the crystallography studies. "This structure has been difficult to obtain, but now that we have it, it has been instrumental in our understanding why this non-neutralizing antibody interacts with the HIV-1 outer coat."

Haynes says the findings are important because they distinguish what parts of the virus an antibody needs to recognize from those parts that are decoys. "We are homing in on a better understanding of what the immune system needs to do in order to mount an effective defense against HIV."


'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
2. Low levels of natural antibodies behind stroke
3. Antibodies linked to cardiovascular disease increase in patients with active lupus
4. Manmade antibodies hold biomedical promise
5. Novel autoantibodies identified in patients with necrotizing myopathy
6. Protecting patients: Study shows that Johns Hopkins flu vaccination rates twice national average
7. Sensis Condoms With QuikStrips(TM) Reminds Lovers To Protect The Passion This Valentines Day
8. One Month Later, Haiti Quake Survivors Report Need For Protection From Crime, Rainy Season
9. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
10. Medical Nurse Training, Inc. Partners With Healthcare Companies to Develop Corporate Branded, Accredited Programs for Patient/Bed Safety and Fall Prevention/Protection
11. Ongoing Toyota Recall Holds Serious Liability Implications For Manufacturer, but Consumers Must Be Protected, Says Texas Attorney Brad T. Wyly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the use of violence and aggression to solve problems and pleads with world leaders to ... and armed forces do not bring peace. He says there is a peaceful and positive ...
(Date:7/21/2017)... Pass, OR (PRWEB) , ... July 21, 2017 ... ... in recent weeks Nature’s Tears® EyeMist®, the signature product of her research center ... country with the world’s largest population and the greatest number of sufferers of ...
(Date:7/21/2017)... CANADA (PRWEB) , ... July 21, 2017 , ... ... insight into why concussion rates are on the rise, say researchers presenting their ... today in Toronto, Ontario, Canada. , “The combination of evaluating the patterns of ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... operations analytics and application performance monitoring (APM) solutions, has expanded its footprint ... providers. , According to Peter Ohrenberger, sales director at Nastel, “We’ve replaced ...
(Date:7/20/2017)... ATLANTA, Ga. (PRWEB) , ... July 20, 2017 , ... ... and equal access to medicine for everyone affected by diabetes, is teaming up with ... the five-day global event kicks off on July 24th. , “Team Type 1’s ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... , July 13, 2017 RK Logistics Group, Inc. ... Pharmacy certification for its Fremont, CA ... in the Tri-Valley and San Jose ... City of Fremont , with its Fremont Innovation District, ... provide such a powerful resource to the hundreds of biotech, ...
(Date:7/12/2017)... July 12, 2017 CarpalAID is a revolutionary new product ... surgery. Carpal tunnel syndrome affects more than 8 million ... the rate of men. The common methods of treating CTS are ... uncomfortable hand braces or gloves. ... CarpalAID is a clear patch worn on ...
(Date:7/11/2017)... July 11, 2017 Zymo Research Corp., also known as ,The ... quantify biological aging in a precise manner using the myDNAge ™ ... , a professor of human genetics and biostatistics at the David ... Public Health , Zymo Research,s proprietary DNAge ™ technology is used ... ...
Breaking Medicine Technology: