Navigation Links
Why so many antibodies fail to protect against HIV infection
Date:11/18/2010

DURHAM, NC Researchers have been stymied for years over the fact that people infected with the AIDS virus do indeed produce antibodies in response to the pathogen antibodies that turn out to be ineffective in blocking infection. Now, scientists at Duke University Medical Center can explain why: Some of the earliest and most abundant antibodies available to fight HIV can't actually "see" the virus until after it's already invaded a healthy cell.

The scientists based their conclusion on the results of a series of crystallography and biochemical experiments that revealed the specific molecular structures different types of antibodies need to have in place in order for them to mount an effective defense.

Previous research had shown that two of the most robust antibodies against HIV antibodies called 2F5 and 4E10 target a specific part of the outer coating of the virus called the MPER region of gp41. The antibodies, which operate in a lock and key relationship, are able to latch on to the virus as it reveals this vulnerable part of its structure, referred to as an "Achilles heel" of the AIDS virus.

"What our studies revealed, however, is that the virus actually creates two versions of this 'Achilles heel,' says Barton Haynes, MD, director of the Duke Human Vaccine Institute (DHVI) and the senior author of the study appearing online in Nature Structural & Molecular Biology. "One version is for these rarer, broadly-neutralizing antibodies, and the other is for the more abundant, first-responding antibodies that won't be able to do much good because the Achilles heel isn't detectable to them until the virus has already gained entry."

Nathan Nicely, PhD, the lead author of the study and a member of the DHVI, designed and conducted most of the crystallography studies. "This structure has been difficult to obtain, but now that we have it, it has been instrumental in our understanding why this non-neutralizing antibody int
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
2. Low levels of natural antibodies behind stroke
3. Antibodies linked to cardiovascular disease increase in patients with active lupus
4. Manmade antibodies hold biomedical promise
5. Novel autoantibodies identified in patients with necrotizing myopathy
6. Protecting patients: Study shows that Johns Hopkins flu vaccination rates twice national average
7. Sensis Condoms With QuikStrips(TM) Reminds Lovers To Protect The Passion This Valentines Day
8. One Month Later, Haiti Quake Survivors Report Need For Protection From Crime, Rainy Season
9. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
10. Medical Nurse Training, Inc. Partners With Healthcare Companies to Develop Corporate Branded, Accredited Programs for Patient/Bed Safety and Fall Prevention/Protection
11. Ongoing Toyota Recall Holds Serious Liability Implications For Manufacturer, but Consumers Must Be Protected, Says Texas Attorney Brad T. Wyly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2013)... (PRWEB) June 17, 2013 "Do you think ... are texting, emailing or using your phone even with a ... warns it is just as dangerous as not using a ... those of you using Facebook, texting, emailing etc." ... and alters their reflexes that distract the brain, according to ...
(Date:6/17/2013)... New York, NY (PRWEB) June 17, 2013 ... Block O'Toole & Murphy, LLP are pleased to ... http://www.blockotoole.com/Attorneys/Stephen-J-Murphy.shtml ) and David L. Scher ( http://www.blockotoole.com/Attorneys/David-L-Scher.shtml ... radio station Z100 (100.3 FM) this Sunday, June ... Mr. Scher will be guests on Kevin Burke's ...
(Date:6/17/2013)... According to a June 11, 2013 ABC News article, titled ... surfaces about the negative effects of sun on the ... skin care routine, as the sun's rays can ... “I agree with the article's suggestions for the best way ... Epione Beverly Hills. “Apply a minimum of SPF 30, twenty ...
(Date:6/17/2013)... As da Vinci robot lawsuit ... Bernstein Liebhard LLP notes that a recent report aired ... the disturbing robotic surgery complications alleged to have been caused ... the June 14th broadcast revealed that the U.S. Food & ... da Vinci patients who suffered burns, cuts and infections since ...
(Date:6/17/2013)... 17, 2013 San Antonio Eye Center PA has ... St. has just opened up a new portion of the office, ... downtown optical shop over the years, and SA Eye Center has ... Center one step closer to providing patients with everything they need ... The downtown optical shop is the largest SA Eye Center in ...
Breaking Medicine News(10 mins):Health News:Dr. Bonnie Weil Warns Hands Free is Not a Life Saver, It Can Be Just as Much of a Distraction 2Health News:Injury Attorneys Block O'Toole & Murphy, LLP to Appear on Z100 Radio Show This Sunday to Discuss Their Support of St. Jude Children's Research Hospital 2Health News:Skin Care – Answers to Your Sunscreen Questions 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on NBC Report Detailing Robotic Surgery Complications 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on NBC Report Detailing Robotic Surgery Complications 3Health News:San Antonio Eye Center PA Opens New Optical Shop 2
... Haiti , Jan. 19 One week later, ... of delivering aid in the aftermath of the Haiti ... aid is beginning to get through, the impact of the ... combined with a destroyed office and warehouse and the loss ...
... , JACKSONVILLE, Fla. and DES ... Inc. ( www.USPreventiveMedicine.com ) will partner with the Iowa Chronic Care ... not yet eligible for Medicare reduce health risks and live longer, ... equal amounts by a grant/cooperative agreement from the Centers for Disease ...
... PHILADELPHIA , Jan. 19 Independence Blue ... been promoted to chief marketing executive. Taylor will report to ... Independence Blue Cross. , As chief marketing executive, Taylor ... Cross (IBC) and two of the company,s third-party administrators:  Independence ...
... , , PHILADELPHIA , Jan. ... Paul A. Tufano has assumed an expanded role of senior ... continue to report to IBC president and CEO Joseph A. ... counsel since November 1999 when he joined IBC. , ...
... , ... Lindt Chocolate , the world,s leading producer of premium chocolate, announces it ... Autism program. For the second year, Lindt will honor ordinary individuals ... home or community.  The Lindt Unsung Heroes of Autism program is part ...
... Providence, RI New research at Rhode Island Hospital has ... brain tumors which, once diagnosed, offer a poor prognosis and ... naturally-occurring hormone combined with chemotherapy, researchers were able to inhibit ... study and their findings are published in the Journal ...
Cached Medicine News:Health News:Haiti Earthquake: One Week Later, Aid Agencies Facing Challenges 2Health News:Iowa Farm Bureau Introduces Bold Initiative to Improve Health Care for Rural Iowans 2Health News:Iowa Farm Bureau Introduces Bold Initiative to Improve Health Care for Rural Iowans 3Health News:Iowa Farm Bureau Introduces Bold Initiative to Improve Health Care for Rural Iowans 4Health News:Taylor Promoted to Independence Blue Cross Chief Marketing Executive 2Health News:Taylor Promoted to Independence Blue Cross Chief Marketing Executive 3Health News:Independence Blue Cross Announces New, Expanded Role For Key Executive 2Health News:Independence Blue Cross Announces New, Expanded Role For Key Executive 3Health News:Autism Speaks and Lindt Seeking Nominations for 'Lindt Unsung Heroes of Autism' 2Health News:Autism Speaks and Lindt Seeking Nominations for 'Lindt Unsung Heroes of Autism' 3Health News:Autism Speaks and Lindt Seeking Nominations for 'Lindt Unsung Heroes of Autism' 4Health News:Researchers find a treatment for deadly brain tumor 2
(Date:6/17/2013)... , June 17, 2013  A little known drug ... under scrutiny by the U.S. Supreme Court – and a ... issue could not have come at a better time for ... result from the Rx industry tactic are all too apparent ... of 50+ New Yorkers, state residents are in a near ...
(Date:6/17/2013)... PHILADELPHIA , June 17, 2013 ... support; program promoted through new ,Wake-Up Call, campaign ... Elsevier , a world-leading provider of scientific, technical ... the launch of EduCode ® Doc ... physicians and other practitioners. EduCode Doc Briefs is ...
(Date:6/17/2013)... , June 14, 2013 The law firm ... commenced what is believed to be the first suit in ... pancreatic cancer in the user of two common anti-diabetic drugs, ... Staten Island resident Robert Cataletto ... Pharmaceuticals, LLC, et al., E.D.N.Y. CV 13-3411. Mr. ...
Breaking Medicine Technology:Supreme Court Ruling on Rx Industry's Pay-to-Delay-Generics Good News for NY Consumers 2Supreme Court Ruling on Rx Industry's Pay-to-Delay-Generics Good News for NY Consumers 3Elsevier Launches EduCode Doc Briefs to Help Physicians Implement ICD-10 2Elsevier Launches EduCode Doc Briefs to Help Physicians Implement ICD-10 3Suit filed for Pancreatic Cancer By Use of Byetta, Januvia and Janumet 2
It provides cranial support in either supine or semi-sitting procedures....
Hudson cranial drill set which includes burr (9 mm), burr (14 mm), burr (16 mm), burr (22 mm), cerebellar extension, brace and sterilizing case....
Children's hospital hand drill, hexagonal handle, twist drill diameter 4.2 mm....
Hudson hand drill with extension piece....
Medicine Products: